Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 65 for “"Anxiolytic"”.
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Investigating the Anxiolytic Effects of Aerobic Exercise for the Treatment of Posttraumatic Stress Disorder
Preliminary evidence has demonstrated the anxiolytic capabilities of aerobic exercise; however, the treatment potential for posttraumatic stress disorder (PTSD) has received comparably less attention. Aerobic exercise may work similar to interoceptive exposure therapy–an empirically supported …
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INTRACRANIAL INFUSIONS OF NEUROTENSIN AGONISTS PRODUCE AN ANXIOLYTIC PROFILE IN A RAT ULTRASONIC VOCALIZATION MODEL
… number of 22-kHz USV calls is indicative of an anxiolytic effect. The current study used a USV model to evaluate the effects of PD149163 (0.1, 1.0, and 10.0 ng) and endogenous NT (0.1, 1.0, and 10.0 µg) when administered into the lateral ventricle of male Wistar rats. Both 10ng of PD149163 and …
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Effect of GABRA2 expression in the central nucleus of the amygdala on anxiety and alcohol's anxiolytic capacity in C57BL/6J mice
… signaling at GABAA receptors, and their anxiolytic effects appear to depend on the presence of α2 subunits in these receptors (Low et al., 2000). The amygdala is widely implicated in both anxiety disorders as well as addiction (Janak & Tye, 2015), and its central nucleus is an important …
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Examining the Roles of GABAA Receptor Subtypes in Anxiety and Anxiolysis: Focusing on the Basolateral Amygdala
… for anxiety-like behaviors, we examined the anxiolytic-like effects, as measured by elevated-plus maze test (EPM), of several subtype selective and non-selective GABA<sub>A</sub>R positive allosteric modulators (PAMs) both in wild type mice and in mutant mice that express BZ-insensitive …
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ASSESSMENT OF NEUROTENSIN RECEPTOR AGONIST EFFECTS ON FEAR-POTENTIATED STARTLE
… receptor agonist PD149163 has exhibited anxiolytic effects in male rats. The present study sought to further evaluate the potential anxiolytic effects of PD149163 by assessing this compound in both male and female C57BL/J6 mice using the fear-potentiated startle (FPS) paradigm. Startle …
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The effects of lavandula angustifolia on animal and human laboratory models of anxiety
… two questions; whether lavender odour exhibits anxiolytic effects in animal models of anxiety, and whether chronically administered lavender is more effective than acutely administered lavender. The second part addressed the question of whether, in a randomised double-blind placebo-controlled …
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The effects of intra-dorsal raphe administration of strychnine on rat behaviour and its interactions with ethanol
… by replicating the previously reported anxiolytic effects in response to the systemic administration of chlordiazepoxide. Animals were divided into two groups and either remained in the home cage or were repeatedly exposed (1 hr/daily) to an elevated open platform stressor over 10 days …
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Ethanol Enhancement of Two Distinct Inhibitory Pathways in the Rat Basolateral Amygdala: Implications for Anxiety and Alcoholism
… EtOH intoxication is known to produce profound anxiolytic effects, while withdrawal from chronic EtOH exposure produces increased anxiety-like behaviors. This suggests that EtOH may interact with brain regions associated with the production of anxiety behaviors, such as the BLA. In addition, …
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Caratterizzazione del clofibrato agonista sintetico dei recettori dei proliferatori dei perossisomi (PPARα)in modelli animali di depressione ed ansia
… effects, which suggests that PEA exerts anxiolytic and antidepressant-like effect in mice (Crupi et al., 2013, Yu et al., 2011). However no studies have been evaluated antidepressant-like effect of synthetic PPARα agonists. Thus, the aim of our study was to characterize the …
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Discovery of Novel Neurologically Active Phytochemicals in Neotropical Piperaceae: An Ethnopharmacological Approach
… aire in the Neotropics and to investigate the anxiolytic and antiepileptic potential of previously unstudied Neotropical members of the genera Piper and Peperomia. Firstly, the literature was reviewed and a regression analysis method was used in order to quantitatively determine which plant …
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Investigating the Role of Neuropeptide Y in the Ventral Hippocampus in Regulating Rats’ Elevated Plus-Maze and Shock-Probe Burying Behaviours
… 3304 but not BIIE 0246, suggesting that this anxiolytic-like effect is associated with the Y1, but not Y2, receptor. Thus, NPY seems to have an anxiolytic-like effect in the ventral hippocampus, in a test-specific fashion, that is associated with the Y1 receptor.
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The long-term effects of reproductive experience on the neurobiology of anxiety and its treatment: a cross species approach in female rats and women
… of estrous cycle on anxiety-like behaviour and anxiolytic drug responsivity in rats. Chapter 2 showed that the estrous cycle impacted anxiety-like behaviour and fear extinction (learned fear inhibition) in nulliparous (virgin) rats, but not primiparous (reproductively experienced) rats. …
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Comparitive activities and mechanisms of action of three novel antiulcer agents
… and it under clinical development as an anxiolytic but which has actions on the stomach and pancreas. Anxiolytic drug is otherwise known as anti-anxiety drugs, which are used to treat anxiety disorders, like depression, panic disorders, phobias and many personality disorders. TOFu is a …
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Neonatal exposure to estradiol in female rats influences neuroactive steroid concentrations and behaviour in the adult rat
… failure. Given that allopregnanolone elicits anxiolytic, antidepressive, anticonvulsant, sedative-hypnotic effects and facilitates social behaviour, we assessed whether this treatment might modify different emotional, cognitive and social behaviours. This treatment did not affect locomotor …
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THE RELATIONSHIPS AMONG MENTAL HEALTH, MEDICINAL DRUGS, DRINKING AND DRIVING AND ROAD RAGE AND MOTOR VEHICLE COLLISIONS ON A REPRESENTATIVE SAMPLE OF ONTARIO ADULTS
… and/or mood disorders, antidepressant and anxiolytic medication use, drinking and driving, and road rage. It is unclear if symptoms of anxiety and/or mood disorders are directly associated with motor vehicle collisions or if other factors mediate the effect. This thesis examines the effects …
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Developmental Effects of Cortisol on the Stress Response and Behaviour in Zebrafish
… stress response, locomotor activity, and was anxiolytic. These phenotypes corresponded with increased region-specific neurogenesis. Post-hatch elevation in cortisol levels by waterborne exposure, mimicking a stress response, increased locomotor activity but did not impact anxiety behaviour. …
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ENDOGENOUS CANNABINOID SYSTEM MODULATION OF THE REINFORCING PROPERTIES OF ETHANOL DURING DEPENDENCE: IMPLICATIONS FOR ALCOHOL USE DISORDERS
… The positive reinforcing aspects (euphoric and anxiolytic effects of acute consumption) predominate during the early regulated, goal-oriented intake of ethanol. As the dependence cycle progresses, the negative reinforcing properties of ethanol (withdrawal induced anxiogenesis) increasingly …
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The role of high affinity nicotinic acetylcholine receptors on anxiety-like behavior: a study in female mice
… to younger mice. Low doses of nicotine produced anxiolytic-like effects, whilst a high dose of nicotine produced anxiogenic-like effects. Activation of the α6*nAChRs supports an anxiolysis-like phenotype. These results implicate α4β2*nAChRs and α6β2*nAChRs in anxiety-like behavior.</p>
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Clinical And Demographic Correlates Of Depression In Stable Heart Failure
… past psychiatric history, antidepressant use, anxiolytic use, insomnia, and taking sleeping pills. A logistic regression incorporating age, gender, NYHA class, asthma, diabetes, and insomnia predicted 84.6% of patients with and without MDD, with insomnia remaining significant at a p = 0.002. …
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The Effect of Alcohol on Attention to Social Threat: A Test of the Avoidance-Coping Cognitive Model
… may be particularly vulnerable to the anxiolytic effects of alcohol through reductions in attention biases to Social threat. Elements of this model and were tested in the present study, in which undergraduate volunteers (N = 41, 27% female) completed two dot probe tasks with photographs …
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