Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Antivirulence"”.
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Formulation development of a novel antivirulence compound for enhanced pharmacokinetic properties
… OF MISSOURI AT AUTHOR'S REQUEST.] A novel antivirulence compound CCG-211790 (termed as C790 in this context), has demonstrated significant inhibition against several severe antibiotic-resistant bacteria. However, its clinical use is restricted by formulation challenges arising from its poor …
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INVESTIGATION OF ANTIBIOFILM AND ANTIVIRULENCE ACTIVITY OF 5-FLUOROCYTOSINE IN ESCHERICHIA COLI
… therapeutics are in demand. In particular, antivirulence agents, that selectively “disarm” pathogenic bacteria rather than killing them, are considered as a promising strategy. Several antimetabolites and nucleobase/nucleoside analogues, such as 5-fluorocytosine and 5-fluorouracil, have been …
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Computationally and Experimentally Exploring the Type IV Pilus Assembly ATPase for Antivirulence Drug Discovery
… is predicted to reach 10 million yearly by 2050. Antivirulence therapeutics have been explored in recent times as another approach to tackling the global ABR pandemic by disrupting the function of virulence factors that promote disease development. The bacterial type IV pilus (T4P) is a prevalent …
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The Type IV Pilus Assembly ATPase PilB as a Regulator of Biofilm Formation and an Antivirulence Target
… factors in many significant human pathogens. Antivirulence chemotherapeutics are considered to be a promising alternative to antibiotics, as they target disease processes rather than bacterial viability. Because PilB is essential for T4P biogenesis, we sought to identify PilB inhibitors for …
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Bacteriodes fragilis interactions with the collagen type I component of the host extracellular matrix
… for novel therapeutic targets. The idea of antivirulence over antimicrobial drug development is becoming increasingly popular and invites detailed research into the virulence factors of target pathogens. The ability to adhere to, and degrade components of the extracellular matrix, such as …
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Investigation of biofilm development by antibiotic resistant urinary tract infection pathogens and evaluation of antimicrobial activity of Manuka honey on Escherichia coli CTX-M-15 biofilms
… CTX-M-15 were investigated in this study. The antivirulence efficacy of Manuka honey as an alternative treatment was analysed for this strain. Method Biofilm formation was measured using the Tissue Culture plate method at different times: after 6, 12, 24 and 48 hours of incubation. Assuming …
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The regulation of bacterial virulence by mucin glycans
… a roadmap for the development of mucin-inspired antivirulence materials for various niches. With the rise of clinical antimicrobial resistance, these materials, which treat infections by hijacking nutrient sensing pathways rather than directly killing bacteria, present a novel strategy for …
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Coordinate Regulation of Salmonella Virulence Gene Expression During Infection
… of Gifsy-1, which we have termed grvB, is an antivirulence gene that is involved in the SodCI-GrvA virulence pathway. GrvB is translocated into the host cytosol in a SPI2 dependent manner.
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Structural underpinnings of membrane association and mechanism in the monotopic phosphoglycosyl transferase superfamily
… thus, opening new avenues for the development of antivirulence agents. A member of the protein glycosylation (pgl) gene locus in C. jejuni, PglC, is predicted single-pass transmembrane (TM) protein, that catalyzes the phosphoglycosyl transferase (PGT) reaction in the first membrane-committed step …
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Anti-candida and Anti-virulence Activity of Essential Oils and Their Components
… to resistance. Further, many components showed antivirulence, and may represent an effective approach for inhibiting Candida, especially in the context of physically preventing Candida from entering its host through catheters and prosthetics.
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Ethnopharmacology of medicinal plants traditionally used in the Greater Mpigi region, Uganda
… of multidrug-resistant human pathogens; d) antivirulence experiments, e.g., monitoring of quorum sensing inhibition and direct protein output (δ-toxin) in Staphylococcus aureus; e) antiinflammatory investigations (e.g., cyclooxygenase-2 inhibition); f) antimalarial studies against …
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Interactions of Proteins with Membranes: Insights from Molecular Dynamics Simulations
… for the structure-based development of new antivirulence agents targeting these toxins. Moreover, due to their ability to selectively interact with specific membrane components and to form pores, PFTs have raised interest for potential biomedical applications, e.g. immunotoxin therapies and …