Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Antiviral resistance"”.
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Examination of Antiviral Resistance in Venezuelan Equine Encephalitis Virus
… there are currently no FDA-approved vaccines or antivirals against VEEV. Efforts have been made to discover small molecules with an inhibitory effect on VEEV, but the potential for emergence of antiviral resistance to these compounds will remain a concern because VEEV is an RNA virus with a high …
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Attenuation of Interferon Responses in the Obese Host and Ramifications for Influenza Virus Evolution
… implications for immunity, including delayed antiviral responses to influenza virus infection, poor recovery, and impaired immunological memory. However, the majority of past work neglected the innate responses, especially the impact on the epithelium. To better understand the innate response …
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Mechanistic Studies of Small Molecule Entry Inhibitors of Influenza A Viruses
… against influenza infections is the use of antivirals and, among those that are FDA approved, the prevalence of antiviral resistance is greatly concerning. Hence, it is crucial to develop anti-influenza inhibitors that exhibit strong effectiveness against novel viral targets. Considering the …
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Exploring the phylodynamics, genetic reassortment and RNA secondary structure formation patterns of orthomyxoviruses by comparative sequence analysis
… in the evolution and possible development of antiviral resistance. The studies herein demonstrate that pathogen genomics-based analytical approaches are useful both for understanding the mechanisms that drive the evolution and spread of rapidly evolving viral pathogens such as …
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Emergence of Adefovir-resistant Mutants after Reversion to YMDD Wild-type in Lamivudine-resistant Patients
… However, it frequently results in marked drug resistance, which has been reported to occur up to 67% by 4 years of therapy. Adefovir dipivoxil (ADV) has been applied for the LAM-resistant patients, and it has shown to be effective against both wild-type and LAM-resistant forms of HBV. A pilot …
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The evolution and genetics of virus resistance in Drosophila
… selective factor that promotes the evolution of resistance in host populations. Much of the resistance is determined by genetic factors, however, it is unclear what genetic factors promote resistance to parasites. In this thesis, I used Drosophila melanogaster as a model system to study the …
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Immune Control of Hepatitis B Virus infection by innate lymphocytes
… several problems including poor tolerance and antiviral resistance and therefore, novel well-tolerated and effective therapies are required. Innate lymphocytes include NK, NT, NKT and T cells and comprise a group of MHC-unrestricted lymphocytes that can elicit potent cytokine production and …