Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Antiviral protection"”.
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Age-Dependent Variability in Immune Host Responses to SARS-CoV-2: Implications for Inclusive Clinical Trial Design
… the immune responses that contribute to protection against SARS-CoV-2 and how these responses become dysregulated with increasing age. Given the evidence of impaired antiviral immunity in aged models, we also evaluated the representation of older adults in COVID-19 vaccine clinical trials …
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THE ROLE OF SELECTIVE MRNA DEADENYLATION IN THE HOMEOSTATIC CONTROL OF INNATE IMMUNE SIGNALING
… Interferon signaling is the specific antiviral arm of the innate immune system responsible for inducing interferons and downstream signaling to control viral infection. While much is known about the stimuli-dependent induction of interferons, less is known about the molecular …
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Engineering the antibody-TRIM21 interface for the improved intracellular clearance of pathogenic targets
… TRIM21-mediated activity, enabling potent antiviral protection in vivo that relies exclusively on TRIM21. Application of this dual-engineering strategy to tau antibodies dampens inflammatory responses in human iPSC-derived microglia and promotes robust intracellular clearance of seeded tau …
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Heligmosomoides polygyrus-induced serum factors limit respiratory syncytial virus titres: a potential role for CCL8
… countries. Previously, there were no effective antiviral treatments, or vaccines for under 75’s and those who were hospitalised received supportive care. Very recently RSV vaccination for those over 75 and passive immunisation against RSV in young infants (nirsevimab, maternal vaccination) have …