Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"Antiviral drugs"”.
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Multifunctional Coronavirus Papain-Like Proteases as Targets for Antiviral Therapeutics and Vaccines
… emerging in the human population there are no antiviral drugs or vaccines to combat coronavirus infection. The focus of my dissertation was to study the multifunctionality of papain-like proteases (PLPs) encoded within coronavirus genomes to facilitate the development of antiviral drugs and …
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Exploring antiviral strategies: From innate immunity modulation to viral proteins targeting
The search for new targets and antiviral agents is continuously growing, especially for agents with broad-spectrum activity. In fact, even though vaccines are the elective way to limit diseases and possibly eradicate pathogens, they are not always effective, particularly in people with compromised …
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Dengue virus and West Nile virus protease inhibitors
… currently there are no approved effective antiviral drugs or vaccines available for the treatment of virus infection. This thesis describes the design, synthesis and discovery of two novel classes of reversible competitive inhibitors of Dengue Virus and West Nile Virus NS2B/NS3 protease. …
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Structure-function of Dengue 2 virus envelope protein domain III with neutralizing antibodies
… against this disease in the form of vaccines and antiviral drugs. Neutralizing antibodies are a critical component of immune-mediated protection from disease caused by the DENVs and the envelope (E) protein is the primary target. Potency of neutralization has been correlated with the particular …
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Structure and dynamics of influenza M2 proton channels from solid-state NMR
… in the United States alone. Developing novel antiviral and vaccines against influenza requires understanding the proteins employed by these infectious virions. The matrix-2 protein (M2) is an essential viral protein that conducts protons in the endosomes of infected host cells and induces …
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Language Models Predict Drug Resistance from Complex Sequence Variation
… a major barrier to the development of vaccines, antiviral drugs, and antibiotics. Recently, neural language models trained on viral protein sequence evolution have shown promise in their ability to predict viral escape mutations, potentially enabling more intelligent therapeutic design [6]. Hie …
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Christian Response to HIV/AIDS: A Teaching Series for the Church in Zimbabwe
… Medical issues and HIV medications such as antiviral drugs for treatment, prevention and transmission from mother to child were explored although there is no cure found yet. Cultural myths expose vulnerable children and women to HIV/AIDS because of culture and tradition. Cultural corrective …
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Identification and Characterization of the Mechanisms of Action of Novel Antiviral Compounds Targeting the Minimal Replication-Transcription Complex of SARS-CoV-2
… the pharmacological target of two of the three drugs currently in clinical use for the treatment of COVID-19, namely remdesivir and molnupiravir. However, the absence of strong evidence of in vivo efficacy and safety still calls for the development of novel safe and potent antiviral drugs, that …
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Intrinsic Flexibility of West Nile Virus Protease: In Solution Characterization
… in humans. Efforts are ongoing to develop antiviral drugs that inhibit the WNV protease, a viral enzyme required for polyprotein processing. Unfortunately, little is known about the solution structure of recombinant WNV protease (NS2B-NS3pro) used for antiviral drug discovery and …
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Semisynthetic Development of Blasticidin S as an Antibiotic Lead and Development of Other Anti-Infectives
… on new computationally identified and optimized antiviral drugs and the future directions of these projects.
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The use of insect cells to identify potent and selective inhibitors of the replication of the Dengue and Chikungunya viruses and unravel their molecular mechanism of action
… can persist for months up to years. There are no antiviral drugs available for DENV and CHIKV treatment and prevention. Moreover, vector control strategies have failed so far. Thus, the development of potent inhibitors for a broad spectrum of RNA viruses is urgently needed. We established and …
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Dissecting the Contribution of the Carboxyl-Terminal Domain and Tail of HIV-1 Integrase to Viral Dynamics and Enzymatic Function
… Immune Deficiency Syndrome (AIDS). Combination antiviral therapy has proven to be particularly effective at suppressing viral replication, yet complete eradication of the virus from an infected individual remains elusive. Recently, a new class of antiviral drugs targeting the viral integrase …
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Analysis of the interaction between the 2C protein of parechoviruses and lipid droplets
… are no vaccines against most picornaviruses so drugs need to be developed. Human parechoviruses (HPeVs) are being increasingly recognised as important human pathogens, but are genetically diverse from other picornaviruses. We therefore need to understand the details of virus replication to …
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Antiviral activity of 3D8 single chain Fv against RNA virus infection
… also have potential activity as an intracellular antiviral antibody. Since 3D8 scFv has RNase activity, 3D8 scFv could hydrolyze almost viral RNA transcripts or genomes replicated in cytoplasmic space without sequence specificity. Above all, RNA genome viruses preferentially replicate their genes …
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A computational approach for identification and development of novel inhibitors targeting viral polymerases
… respectively, hastening the need for effective antiviral drugs. Likewise BVDV infects domesticated livestock causing significant economic losses worldwide. The development of new, effective antiviral compounds for combating these debilitating human (HIV and HCV) and animal pathogen (BVDV) is …
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Expression Of Hepatitis C Viral Non-structural 3 Antigen In Transgenic Chloroplasts
… to prevent hepatitis C. The treatment with antiviral drugs is expensive, accompanied with various side effects and is limited only to those at risk of developing advanced liver disease. The treatment is also effective in only about 30% to 50% of treated patients and still a high percentage …
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Study of Infection, Immunity, Vaccine and Therapeutics Using Gnotobiotic Pig Models of Human Enteric Viruses
… immunity, and to evaluate vaccine and antiviral drugs. Using the well-established Gn pig model for HRV, the adjuvant and therapeutic effects of prebiotics rice bran (RB) and probiotics were evaluated. RB alone or RB plus probiotic Lactobacillus rhamnosus GG (LGG) and probiotic E. coli …
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Predicting the Interactions of Viral and Human Proteins
… unprepared for deadly viral outbreaks. Designing antiviral drugs and strategies requires a firm understanding of the interactions taken place between the proteins of the virus and human proteins. The current computational models for predicting these interactions consider only single viruses for …
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Structural determinants of murine leukemia virus (MLV) reverse transcriptase (RT) important for fidelity and drug resistance in vivo
… exhibit altered host tropisms, resistance to antiviral drugs, and the ability to escape the host's immune system. To identify structural elements of murine leukemia virus (MLV) RT important for fidelity and drug-resistance in vivo, we developed a D17-based encapsidating cell line (ANGIE P) …
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Differential modulation of HIV-1 capsid uncoating kinetics revealed by a novel single-particle uncoating assay
… capsid has been recognised as an attractive antiviral target due to its central role during infection. It acts as a shield to protect the viral genome, facilitates reverse transcription, engages with the nuclear pore complex, and directs integration site targeting. To achieve all of these …
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