Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Antiviral compounds"”.
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Analyzing the role of a cellular mechanism in HIV infection and Evaluation of novel antiviral compounds
… has been found. For the development of novel antiviral compounds, understanding of the HIV lifecycle as well as the molecular mechanisms of host pathogen interactions are a prerequisite. Like all viruses, HIV subcontracts cellular machineries for efficient replication and production of new …
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Identification and Characterization of the Mechanisms of Action of Novel Antiviral Compounds Targeting the Minimal Replication-Transcription Complex of SARS-CoV-2
… for the development of novel safe and potent antiviral drugs, that could combat this and other future threats from emerging coronaviruses. In the present work, we purified the viral proteins and set up a biochemical assay for the identification and molecular characterization of different …
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Defining the mechanism(s) of Hepatitis C virus (HCV) entry
… in vitro, making the evaluation of potential antiviral compounds in a biologically relevant context extremely difficult. Despite being suitable for high-throughput screening, most cell-based reporter assays rely on the secretion of serine alkaline phosphatase and thus do not allow the …
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Examination of Antiviral Resistance in Venezuelan Equine Encephalitis Virus
… there are currently no FDA-approved vaccines or antivirals against VEEV. Efforts have been made to discover small molecules with an inhibitory effect on VEEV, but the potential for emergence of antiviral resistance to these compounds will remain a concern because VEEV is an RNA virus with a high …
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Studying the biology of, and developing countermeasures to, a tick-transmitted hemorrhagic fever virus
… also demonstrated its use in a screening of antiviral compounds targeting the GPC. Both rVSV constructs were further evaluated as vaccines for CCHF. Varying degrees of efficacy were observed depending on the construct and experimental conditions, with up to a 100% efficacy observed using the …
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A study of norovirus: molecular epidemiology, pathogenesis and antiviral development
… due to the lack of effective vaccine or antiviral. This is partly due to limitations in propagating human NoV in cell culture, which has hampered the study of NoV biology, antiviral development and pathogenesis. Another aim of this thesis was to understand how MNV infection avoids the …
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Development of an Assay to study the Kinetics of HIV-1 Capsid Uncoating
… for its use as a screening assay for testing antiviral compounds targeting capsid uncoating events.
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In vitro inhibition of coronavirus replications
… medicinal herbal extracts and evaluated their antiviral activities on coronavirus replication. We employed a plaque assay to evaluate the effect of 29 medicinal herbal extracts of virus replication. We determined the 50% effective concentration (EC50) of each extract that was necessary to …
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A computational approach for identification and development of novel inhibitors targeting viral polymerases
… respectively, hastening the need for effective antiviral drugs. Likewise BVDV infects domesticated livestock causing significant economic losses worldwide. The development of new, effective antiviral compounds for combating these debilitating human (HIV and HCV) and animal pathogen (BVDV) is …
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The Therapeutic Potential of Natural Products from <i>Vaccinium</i> Berries for Viral and Lung Diseases Through an Improved LC-MS-Based Chemometric Approach
… effects of cranberry and blueberry compounds combined with trends towards organic farming may offer further areas of growth and development for these crops.</p> <p><em>Vaccinium</em> berries have been studied for centuries, but their full potential to ameliorate lung and viral …