Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"Antiviral agents"”.
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Design, Chemical Synthesis and Biological Evaluation of Potential New Antiviral Agents
… transcriptase inhibitors (NNRTIs) were the early agents introduced in the therapy and currently they are the most used, based on their concurrent high activity against the virus and low toxicity against human cells. In addition, the rapid development of virus resistance against these types of …
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Synthesis of 3'-deoxy- and 2',3'-dideoxy-4'-C-alkyl-D-nucleosides: potential antiviral agents
… target nucleosides are of interest as potential antiviral agents. Crucial features addressed by the methodology are: the ability to synthesize nucleosides analogs with a variety on 4'-C-alkyl substituents; exceptional stereocontrol over the C4' stereogenic center; and a semi-convergent synthesis, …
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Antiviral Agents: 3,5-Disubstituted 1,2,4-Oxadiazole Derivatives and Novel Peptidomimetics Containing Hydroxyethyl Isostere and Imidazolidinone Structures
<p>The search for new compounds with biological activity is the major goal of medicinal research.</p><p>One way to discover new lead compounds is the screening of large compound libraries, followed by the optimization of the found compounds. With this method, <b>A3</b> was recently identified as a …
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Functional Investigation of RNA Viral Helicases as Molecular Targets for the Discovery of Novel Antiviral Agents
… class still underexplored, that lacks approved antiviral agents. In this respect, the identification of first-in-class inhibitor scaffolds is a promising achievement to pursue. The work is focused on the helicases of Coronaviruses, specifically the NSP13 of SARS-CoV-2, and of Flaviviruses, …
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A comparative study of white, black and green tea solutions as potential antiviral agents in rhesus monkey kidney cells induced with porcine rotavirus
… Black, and Green Teas may play a role in their antiviral activity, against rotavirus survival in aqueous environments. Further studies are needed to understand the mechanisms between tea extract, polyphenols, and their anti-viral capacity to inhibit porcine rotavirus.
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Understanding the mechanism of antiretroviral nucleoside analogs as inhibitors of Epstein-Barr virus lytic DNA replication
… DNA y-herpesvirus. To date, there are no antiviral agents proven to be clinically effective in the treatment of EBV infection or EBV-associated diseases. In the experiments contained in this thesis, we define the ability of nucleoside/nucleotide analogs licensed for the treatment of HIV to …
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Exploring antiviral strategies: From innate immunity modulation to viral proteins targeting
The search for new targets and antiviral agents is continuously growing, especially for agents with broad-spectrum activity. In fact, even though vaccines are the elective way to limit diseases and possibly eradicate pathogens, they are not always effective, particularly in people with compromised …
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The Impact of Nucleoside Sugar Modification on Biochemical DNA Transactions
… an important class of cytotoxic, antitumor and antiviral agents. The results of these studies will likely provide a clearer understanding of the role of sugar conformation in the fidelity of DNA synthesis and replication as well as reveal important insights into the activity and toxicity of …
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Towards the Design of an oligoTEA Endosomal Escape Agent: Investigations in Hydrophobicity and pKa
… ranging from use as antibacterial and antiviral agents, to use as heteromultifunctional cross-linkers and cell penetrating agents. The problem of endosomal escape in intracellular drug delivery represents an arena where this family of macromolecules may find potential use. Here, I …
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Characterization of cholesterol 25-hydroxylase expression in human macrophages
… (CH25H) has been shown to exert broad antiviral properties. Given its antiviral activities, CH25H is part of an increasingly appreciated connection between type I interferon (IFN-I) and lipid metabolism. Moreover, the details of this connection appear to differ in mouse and human cells. …
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Influenza Antivirals in Adults: Analyzing Usage Trends, GI Safety, and Cardiovascular Risk Reduction
This dissertation explores how influenza antiviral therapy is used in everyday clinical practice among U.S. adults, with a focus on its safety profile and potential cardiovascular benefits. Seasonal influenza remains a major public health concern, contributing to substantial morbidity, mortality, …
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The effect of Coxsackie virus A9 infection on nuclear and nucleolar proteins
… target for the development of a new class of antiviral agents against this important group of viruses.
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A study of immune responses during antiviral treatment for hepatitis C virus infection
… chronic hepatitis C infection. Interferon based antiviral therapies failed to recover HCV specific CD8+ T cell function suggesting that the damage to T cells may be permanent even after antigen removal. Chronically infected patients show poor response to treatment with pegylated interferon- and …
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INNATE IMMUNITY IN ENCEPHALITIC BUNYAVIRUS INFECTION: OVERCOMING NEURONAL VULNERABILITY
… immune responses. Innate immunity, including the antiviral interferon (IFN) and inflammatory NF-κB pathways, coordinates host responses to pathogens. It is unclear whether neurons are able to detect RVFV and LACV and mount an effective antiviral response, as neurons have likely adapted to minimize …
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Synthesis of phosphorus/sulfur-based antivirals
… to the rapid mutation rate of the virus. Novel antivirals are continually required to combat evolving resistance. By making structural modifications to existing antiviral agents, the rate of antiviral incorporation into the viral DNA chain may be accelerated leading to more rapid termination of …
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Ocular pharmacokinetics and efficacy of various amino acid and dipeptide prodrugs of ganciclovir
… but also affect their daily life. Often, these antiviral agents are administered along with steroids to reduce the corneal inflammation. Application of ointments and gels restrict the concomitant usage of topical steroids solutions. To address the above issues, goals were set to prepare high …
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A study of norovirus: molecular epidemiology, pathogenesis and antiviral development
… due to the lack of effective vaccine or antiviral. This is partly due to limitations in propagating human NoV in cell culture, which has hampered the study of NoV biology, antiviral development and pathogenesis. Another aim of this thesis was to understand how MNV infection avoids the …
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Insights into Virus-Host Interactions: Regulation of Cytokine Signaling Is a Virulence Determinant of West Nile Virus
… (IFN) and its downstream activation of an antiviral state within the infected cell and neighboring tissue. To begin to understand how WNV evades host defenses, studies were initiated to examine the interaction of virulent (TX02) and avirulent (MAD78) WNV strains with the host IFN system. …
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Two enantiodivergent syntheses of balanol and the chemoenzymatic synthesis of oseltamivir
The present thesis outlines our latest findings on the reactivity of the Burgess reagent with oxiranes. Structural, mechanistic, and computational studies are presented. Included is the development of a (-)-menthyl version of the Burgess reagent and its application to the synthesis of …
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