Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 550 for “"Antiviral"”.
-
Autophagy in Antiviral Immunity
Autophagy is an evolutionarily conserved pathway in which cytoplasmic material is sequestered in a double-membrane vesicle and delivered to the lysosome for degradation. During times of stress, autophagy functions to generate essential nutrients through the degradation of non-essential cytoplasmic …
-
Understanding Host Antiviral Signaling Pathways
… also other molecular components involved in the antiviral signaling pathway. A bioinformatics approach led to the identification of a CARD domain containing protein, termed MAVS (Mitochondrial AntiViral Signaling protein) that functions downstream of RIG-I in the antiviral signaling pathway. …
-
Characterization of the Antiviral Effector IFI6
… the innate immune response, which establish an antiviral state in the cell. Flaviviruses such as dengue virus, Zika virus, and West Nile virus rely intimately on host pathways for completing a replication cycle, and have developed strategies to overcome the inhibitory effect of the innate immune …
-
Antibody-Effector Functions in Antiviral Response
<p>Antibodies are a fundamental component of the adaptive arm of the immune system. Interactions of the antibody's fragment crystallizable (Fc) domain with Fc receptors (FcR) on effector leukocytes is essential for proper immunological function and bridges the humoral with the cellular components …
-
Single molecule investigation of antiviral signaling
… gene 1 (RIG-I) plays a major role in antiviral innate immunity by detecting cytoplasmic viral RNA and triggering the pathway that leads to transcriptional activation of type I interferon (IFN). Type I IFN induces a large set of genes called interferon-stimulated genes (ISGs) that …
-
Antiviral polymeric drugs and surface coatings
… multivalent therapeutics (multiple copies of an antiviral agent covalently attached to a polymeric chain) with superior potency against their viral targets, and (ii) creating antiviral surface coatings that detoxify aqueous solutions containing various viruses on contact. By harnessing the power …
-
ENDOGENOUS ANTIVIRAL PROPERTIES OF RED BLOOD CELL-DERIVED EXTRACELLULAR VESICLES AND THEIR AUGMENTATION OF ANTIVIRAL OLIGONUCLEOTIDE THERAPY
… the urgent need for effective and accessible antiviral therapies. We explored the intrinsic antiviral activity of red blood cell-derived extracellular vesicles (RBCEVs) against SARS-CoV-2 and their use as delivery vehicles for antisense oligonucleotides (ASOs). RBCEVs inhibited both …
-
Optimization of influenza antiviral response in Texas
… to respond to potential influenza pandemics with antiviral, vaccine, and social interventions. Mathematical models can guide policies to saves lives. In this thesis, we create an optimization model, implemented in the online tool Texas Antiviral Release Scheduling (TAVRS) that provides the optimal …
-
Evolution of antiviral breadth in Mx GTPases
… However, the molecular basis for how host antiviral defenses overcome the daunting challenge of viral diversity and the highly adaptive nature of viral pathogens is poorly understood. Viral pathogens and their infected hosts are engaged in a constant battle to gain evolutionary dominance. …
-
Antiviral activities of selected Chinese medicinal plants
… of China were collected and screened for antiviral activity. Plants that were used to treat diseases that are now known to have viral causes were selected through a systematic survey of information on traditional Chinese medicine and the traditional medicines of ethnic minority groups in …
-
Small RNA-based antiviral defense in insects
Contains fulltext : 131645.pdf (Publisher’s version ) (Open Access)
-
Structures of the Didemnins (Antiviral, Antitumor, Compounds)
The didemnins (shown below), promising new antiviral and antitumor depsipeptides, have been isolated from a Caribbean tunicate. Their amino acid compositions were ascertained by gas chromatography/mass spectrometry of the trifluoroacetyl n-butyl ester derivatives of the amino acids present in the …
-
Are bats evolving more potent antiviral immune systems? Investigating the evolution and antiviral capacity of SERINC3 in Rhinolophus bats
… in a recent study has revealed a pattern of antiviral immune genes under positive selection across various bat species. One of these genes is the antiviral restriction factor SERINC3. The SERINC protein family is a collection of transmembrane proteins conserved amongst mammals. SERINC3 and …
-
The inducible antiviral immune response of Drosophila melanogaster
… wurde nicht als eine bedeutende Komponente der antiviralen Immunantwort identifiziert. Trotzdem zeigten Mutanten dieses Signalweges eine Tendenz zu reduzierten viralen Titern nach Dicistrovirus Infektion. Wir zeigten weiterhin, dass re- lativ gesehen, der Jak-STAT Signalweg genauso bedeutend für …
-
Chromatin Control of the Antiviral Response to Influenza
… Loss of PAF1C function leads to an impaired antiviral response and increased influenza viral replication. Genome-wide binding analyses indicate that PAF1 is inducibly recruited to anti-viral and inflammatory genes during infection, and that its presence coincides with the recruitment of RNA …
-
Characterizing novel molecular regulators of antiviral gene expression
… pathogens. For the early establishment of an antiviral cellular state and initiation of inflammatory responses, type I interferons (IFNs) are particularly important, as they potently induce the production of hundreds of IFN-stimulated genes (ISGs), many of which have antiviral functions. The …
Page 1 of 28