Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Antitumor agents"”.
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Primary photoprocesses of light-activated antiviral and antitumor agents, hypericin and hypocrellin
… of the title anti-viral and anti-cancer agents, whose activity depends on light which is also accompanied by photoacidification in vesicles and living cells;By complementing the techniques of time-resolved absorption spectroscopy with those of fluorescence upconversion and applying them …
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NATURAL POLYPHENOLS AS LEAD COMPOUNDS IN THE SYNTHESIS OF ANTITUMOR AGENTS AND OTHER USEFUL PRODUCTS
… AS LEAD COMPOUNDS IN THE SYNTHESIS OF ANTITUMOR AGENTS AND OTHER USEFUL PRODUCTS Abstract Some polyphenol dimers, such as lignans, neolignans and stilbenoid lignans, because of their biological properties as well as their structural variety, are an attractive target for chemical …
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STRUCTURE–ACTIVITY RELATIONSHIP STUDIES OF HYBRID ANTITUMOR AGENTS FOR THE TREATMENT OF NON-SMALL CELL LUNG CANCER
… DNA binder that, unlike clinical platinum agents, does not induce DNA cross-links. The research in this dissertation was concerned with establishing structure–activity relationships (SAR) in this novel class of DNA-targeted antitumor agents with the ultimate goal of improving the biological …
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NAD(P)H:QUINONE OXIDOREDUCTASE (NQO1)-DIRECTED LAVENDAMYCIN ANTITUMOR AGENTS: STRUCTURE-BASED DESIGN, MOLECULAR MODELING AND STRUCTURE-ACTIVITY STUDIES
… activation of many quinone-based antitumor agents. NQO1, expressed at high levels in many human solid tumors, can be used as a target for enzyme-directed bioreductive antitumor drug development. We hypothesized that lavendamycins, quinolinedione antitumor antibiotics, can be …
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NAD(P)H:QUINONE OXIDOREDUCTASE (NQO1)-DIRECTED LAVENDAMYCIN ANTITUMOR AGENTS: STRUCTURE-BASED DESIGN, MOLECULAR MODELING AND STRUCTURE-ACTIVITY STUDIES
… activation of many quinone-based antitumor agents. NQO1, expressed at high levels in many human solid tumors, can be used as a target for enzyme-directed bioreductive antitumor drug development. We hypothesized that lavendamycins, quinolinedione antitumor antibiotics, can be …
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Studying the Efficacy of an Injectable 3-Dimensional Fibrin Extracellular Matrix to Characterize the Effects of Antitumor Agents on SW620 Cells in a Microfluidic Device
… is currently a lot of research going into new antitumor agents to kill the cancer. One method for replicating the tumor response to a drug in vivo is by creating an in vitro drug testing model to replicate the in vivo condition. This research project was conducted to determine the efficacy of …
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Synthesis and biological evaluation of potential DNA cross-linking agents based on pyrrolizidine alkaloids
DNA cross-linking agents represent one of the most potent categories of antitumor agents. Pyrrolizidine alkaloids are an abundant class of biologically active natural products. These alkaloids display high levels of DNA cross-linking ability, and could have potential use as antitumor agents. …
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Synthesis of furo[2,3-d]pyrimidines, thieno[2,3- d]pyrimidines, pyrrolo[2,3-d]pyrimidines as classical and nonclassical antifolates, receptor tyrosine kinase (RTK) inhibitors and antimitotic agents
… tyrosine kinase (RTK) inhbitors and anti mitotic agents has been discussed. Thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFTase) are important folate dependent enzymes that are targets for cancer chemotherapy and the treatment of …
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Investigations in the chemistry of transition metal complexes containing the tripodal amine β,β′,β″-triaminotriethylamine
… has been cited as one of the most promising antitumor agents tested in recent years, and chromium(III) and rhodium(IlI) complexes of the same type are being subjected to extensive investigation.</p> <p>It is hoped that the fundamental studies reported here will make some contribution to our …
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Discovery of Pyrimidine-based Heterocycles as Single Agents With Combination Chemotherapy Potential And As Inhibitors Of Purine Nucleotide Biosynthesis For The Treatment of Cancer
… bicyclic pyrimidine-base heterocycles as single agents with combination chemotherapy potential having both antiangiogenic effects and cytotoxic effects. This dissertation also describes selective tumor targeting with 5-substituted pyrrolo[2,3-<em>d</em>]pyrimidines analogs with heteroatom bridge …
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APPROACHES TO THE TOTAL SYNTHESIS OF DICTYOSTATIN AND SYNTHESIS OF EPI-DICTYOSTATINS
… one of the most potent microtubule stabilizing agents discovered to date. In this PhD thesis, I report on a highly stereoselective total synthesis of (+)-9-epi-dictyostatin, whose key steps is the coupling reaction between two fragments, C1-C9 and C10-C26, followed by Yamaguchi …
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Design and synthesis of new potential anticancer agents and high-selective A2B antagonists
The synthesis of antitumor agents covers a large part of current medicinal chemistry efforts. This thesis mainly focuses on the synthesis of different scaffolds as new potential anticancer agents. Two different approaches were applied: a hybrid concept and a rational based drug design. In the first …
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Design and Synthesis of Pyrimidine Fused Heterocycles as Single Agents with Combination Chemotherapy Potential
… of pyrimidine fused heterocycles as single agents with combination chemotherapy potential. Major limitations of cancer chemotherapy include dose limiting toxicities of clinically used agents and the development of multidrug resistance by the tumor. Agents that interfere with microtubules are …
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A Preclinical Model of Ionizing Radiation and TNF-alpha Gene Therapy for Cancer
… of radiation and other genetically delivered antitumor agents against more different forms of tumor.</p>
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Mechanistic investigation of anticancer agents that damage DNA and interact with the estrogen receptor
… goals of cancer chemotherapy is the design of antitumor agents that achieve selective targeting of tumor cells while minimizing toxicity to normal tissues. We have synthesized a series of DNA damaging agents that are designed to disrupt selectively the DNA repair and signaling pathways in tumor …
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Echogenic Liposomes For Nitric Oxide Delivery and Breast Cancer Treatment
… have been proposed as a carrier for drugs and antitumor agents in cancer chemotherapy. Echogenic liposomes (ELIP) have the potential to entrap air or bioactive gas to enhance acoustic reflectivity in ultrasound and are used as a contrast agent. The innovative part of this study is based on a …
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Design and Synthesis of Pyrimidine Based Heterocycles as Potential Anti-cancer Agents with Combination Chemotherapeutic Potential or Targeted One Carbon Metabolism Inhibition and Anti-opportunistic Agents
… pyrimidine-based heterocycles as a) single agents with combination chemotherapy potential having dual antiangiogenic effects and cytotoxic effects or b) one-carbon metabolism inhibitors for targeted tumor therapy; or c) selective <em>Pneumocystis jirovecii </em>(pj)<em> </em>dihydrofolate …
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Design and synthesis of pyrimido[4,5-b]indoles and furo[2,3-d]pyrimidines as single agents with combination chemotherapy potential or as inhibitors of tubulin or thymidylate synthase
… progress in the areas of multitargeted single agents and tubulin inhibitors in cancer chemotherapy and selective Toxoplasma gondii TS inhibitors for the treatment of toxoplasmosis.</p><p> Tubulin inhibitors are important antitumor agents that disrupt microtubule dynamics. Thymidylate synthase …
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The synthesis and study of multimetallic Platinum Group Metal complexes as in vitro phamacological agents
… have bred a need for novel pharmacological agents. Thus, the design and study of organometallic complexes as potential chemotherapeutics may potentially identify new drug candidates. Apart from platinum based compounds, platinum-like metals such as ruthenium(II), rhodium(III) and …
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AKR1B8 IS A NOVEL MODULATOR OF CRYPTIC SELF-RENEWAL AND SUSCEPTIBILITY TO COLITIS AND ASSOCIATED CANCER
… and induces drug resistance to cytostatic antitumor agents containing carbonyl groups such as daunorubicin, resulting in failure of treatment. AKR1B10 may also participate in cell differentiation and carcinogenesis by depleting the precursor of cellular retinoic acid, a signaling molecule, …
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