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Showing 1 to 12 of 12 for “"Antisolvent crystallization"”.
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Stochastic modeling of nonisothermal antisolvent crystallization processes
In this Thesis a stochastic approach to model antisolvent crystallization processes is addressed. The motivations to choice a stochastic approach instead of a population balance modeling has been developed to find a simple and an alternative way to describe the evolution of the Crystal Size …
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Crystal Engineering In Antisolvent Crystallization Of Neodymium Sulfate
Antisolvent crystallization is a separation technology that separates a solute from the solvent by the addition of another solvent, in which the solute is sparingly soluble. High yields are achieved by using higher antisolvent-to-solvent ratios, but this generates higher supersaturation, which …
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Modeling and Simulation of Antisolvent Crystallization: Mixing and Control
… to address the issues of mixing and control in antisolvent crystallization processes, and to aid the development of systematic and scientific design approaches. The first part presents the development of an algorithm that couples macromixing and micromixing models with the population balance …
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Direct Precipitation of Micron-Size Salbutamol Sulphate by Antisolvent Crystallization
… of desired size (between 1 and 5 ?m) through antisolvent crystallization in the presence of surfactants and polymeric additives. Salbutamol sulphate (SS) was used as the model drug compound. Several candidate antisolvents were screened via studying particle morphology, particle size and …
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Multiscale Modeling and Mechanistic Analysis of Crystallization and Particulate Processes
Crystallization is a critical separation and solid-form control step in pharmaceutical and materials manufacturing, yet the mechanisms to understand molecular interactions, nucleation, growth, and particle evolution remain incompletely understood. Key knowledge gaps persist in explaining how …
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Study of nucleation mechanisms and rational design of small-scale continuous crystallizers
Crystallization is a separation process widely used in several important industries such as food, pharmaceuticals, and specialty chemicals, where crystallization serves as the final step of purification and isolation. Crystallization is a two-step process: nucleation (birth of crystals) and crystal …
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Computational Fluid Dynamics and Population Balance Modeling of Particulate Systems
… aid in the design of process equipment for the crystallization of pharmaceutical compounds. The models focus on the combination of population balance equations and computational fluid dynamics software. For the simulation of antisolvent crystallization, knowledge of kinetics at high …
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Optimal Control of Antisolvent and Cooling Crystallization
Common quality requirements for crystallization products is so critical in the pharmaceutical industry, including the demands of the drug administration and customers (e.g. bioavailability, size uniformity, and polymorphic form) and the concern of the manufacturer for downstream processes such as …
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Crystalization studies in hollow fiber devices
Crystallization was examined under a new perspective and in a flow environment much different from that available in currently used industrial devices. Three crystallization techniques were tested in the unique flow environment offered by hollow fiber devices. In addition, a new type of heat …
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A thermodynamic framework for the modeling and optimization of crystallization processes
Crystallization is a widely used chemical engineering separation unit operation process. Since this technique can produce high purity products it is used for the industrial production of many chemical compounds, such as pharmaceuticals, agrochemicals, and fine chemicals. The production of these …
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Mathematical modeling and design of novel semi-continuous and continuous crystallizations
Crystallization is an important separation technology used for the purification of products during their final stages of manufacturing. Novel semi-continuous and continuous crystallization process designs are receiving increasing attention in pharmaceutical industry due to significant advantages in …
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Control of polymorphism in continuous crystallization
… of studies on the process dynamics in continuous crystallization, in particular in yield improvement and impurity separation, the research community lacks the systematic understanding of the control of polymorphism in continuous crystallization. Variations in the polymorphism of the active …