Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 57 for “"Antiretroviral drugs"”.
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Supramolecular modification of selected antiretroviral drugs
A number of antiretroviral drugs that are currently in use for anti-HIV therapy have extremely poor aqueous solubility. This, along with the fact that many of these pharmaceutical compounds possess potential hydrogen bond donor and acceptor functionalities, makes them ideal candidates for attempted …
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Acceptability of Antiretroviral Drugs among adults living in Chawama, Lusaka
Acceptability of Antiretrovirals (ARVs) has been found to be associated with several factors. In this study we investigated the level of willingness among adults living in Chawama and factors likely to be associated with willingness to taking ARVs This was a cross sectional study. Only eligible …
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Acceptability of Antiretroviral Drugs among adults living in Chawama, Lusaka
Acceptability of Antiretrovirals (ARVs) has been found to be associated with several factors. In this study we investigated the level of willingness among adults living in Chawama and factors likely to be associated with willingness to taking ARVs This was a cross sectional study. Only eligible …
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Antiretroviral drugs differentially modulate glucocorticoid activity via the glucocorticoid receptor in vitro
Concurrent use of anti-retroviral drugs (ARVs) and progestin-based hormonal contraceptives is widespread. During times of stress and during glucocorticoid (GC) therapy, intracellular ARVs are in the presence of high concentrations of GCs, which regulate all aspects of immunity and inflammation via …
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Modulation of the progesterone receptor by progestogens, antiretroviral drugs and the glucocorticoid receptor
… and PR-B, progestogen metabolism, the role of antiretroviral drugs (ARVs) and crosstalk with the glucocorticoid receptor (GR). The PR isoforms play important roles in multiple physiological processes, including cognition, regulation of inflammation, mitochondrial function, neurogenesis, female …
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Determination of total, unbound, and intracellular concentrations of the antiretroviral drugs Efavirenz, Lopinavir, and Ritonavir
Efavirenz, lopinavir, and ritonavir are antiretroviral drugs used for the treatment of HIV in South Africa. Plasma concentrations of these drugs are routinely monitored to ensure efficacy, minimise adverse effects, and adjust dosing. However, variability exists in patient treatment response and …
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Analysis of the role of nuclear factor-kappa B in insulin resistance caused by antiretroviral drugs
… significantly declined since the introduction of antiretroviral treatment and other non-medical interventions such as the distribution and use of condoms. The introduction of antiretroviral treatment has however led to insulin resistance amongst users. Clustered regularly interspaced short …
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Benefit incidence analysis of antiretroviral drugs in Uganda : a case study of Kampala and Masaka districts
… increasing pressure to provide life sustaining antiretroviral (ARV) drugs to countries in most urgent need of them. Antiretroviral Therapy (ART) has been identified by policy-makers in Uganda as a potential programme aimed at mitigating the pervasive effect of HIV / AIDS on the social and …
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Prescribing patterns of antiretroviral drugs in the private health care sector in South Africa : a drug utilisation review
… infected do not have access to even the basic drugs needed to treat HIV-related infections and other conditions (Wikipedia, 2004:3). The relative high price of many of the antiretroviral (ARV) drugs and diagnostics on the other hand are one of the main barriers to their availability in …
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Pharmacogenomics and pharmacokinetics of antiretroviral drugs and their associations with metabolic complications in HIV-infected Black South Africans
BACKGROUND: Antiretroviral therapy (ART), notably efavirenz and lopinavir, have been associated with metabolic abnormalities known to increase cardiovascular risk. Efavirenz and lopinavir pharmacokinetics demonstrate considerable interindividual variability, which in part, may be explained by host …
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Quantification, phase distribution, and persistence of antiretroviral drugs in wastewater treatment systems and their ecotoxicological impacts in aquatic environments
South Africa has the world’s largest antiretroviral therapy (ART) programme, treating more than 5.5 million people, which has resulted in high levels of antiretroviral drugs (ARVs) in wastewater and environmental waters. Despite this scale, the occurrence, fate, and ecological effects of ARVs in …
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Functional Expression of ABC Transporters at Blood-tissue Barriers: Relevance to Antiretroviral Drug Tissue Distribution
Although combination antiretroviral therapy is successful in reducing HIV-1 viral loads in plasma, several tissue compartments i.e., the brain and male genital tract have been identified as viral reservoirs which can harbor actively replicating HIV-1 virus (Chan, 2005;Dahl, et al., 2010;Smith, et …
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Hiv And Antiretrovirals In The Central Nervous System: Molecular Mechanisms Of Cognitive Impairment
… despite viral suppression by combined antiretroviral therapy. Reasons for the persistence of this disease are unknown, but may be related to both the presence of HIV-infected macrophages in the central nervous system as well as neurotoxicity of antiretroviral drugs. In this thesis, we …
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A cross-country analysis of the determinants of antiretroviral drug coverage
… that impact onthe coverage of highly active antiretroviral treatment (HAART) and mother-to-childtransmission prevention (MTCTP) in different countries. Both HAART and MTCTP arebased on the administration of antiretroviral drugs and constitute an integral part of asuccessful response to the …
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Mucosal HIV-1 Transmission in Humanized Mice
… herein that pre-exposure prophylaxis with antiretroviral drugs can prevent intravaginal HIV-1 transmission. This experimental finding has important implications for the clinical implementation of antiretroviral-based pre-exposure prophylactic measures to prevent the spread of AIDS. The goal …
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Predicting district level HIV prevalence in South Africa using medicine ordering data
… million People Living with HIV have access to antiretroviral treatment at present day. Dynamic, mechanistic models such as the Thembisa and Naomi Bayesian models have been used to generate provincial and district-level estimates such as HIV prevalence, People Living with HIV, and the number of …
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Combating HIV-1 by Targeting Drug Efflux Transporters on the Macrophage Reservoir
… the virus can reside and replicate even under antiretroviral drug therapy (ART). Infected macrophages, which represent a long-term viral reservoir have been shown to lead to viral rebound independently. In response to the environmental stimuli, macrophages can be polarized into different …
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Mathematical modelling of host-disease-drug interactions in HIV disease
… low viral burden and typically involve multiple drugs. The choice of optimal combinations of these drugs is crucial, particularly in the background of treatment failure having occurred previously with certain other drugs. An understanding of the dynamics of viral mutant genotypes aids in the …
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A visual analysis of HIV/AIDS antiretroviral therapy print campaign materials found in four Western Cape community clinic environments
… Deficiency Syndrome (AIDS), the introduction of antiretroviral treatment (ART) into the South African health sector presented a major communications challenge, namely how best to communicate awareness and administration of the drugs and how they should be taken. Over the past ten years, the …
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