Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"Antiretroviral Treatment (ART)"”.
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Adherence to antiretroviral treatment (ART) among HIV-infected pregnant women starting treatment immediately vs delayed: a cohort study
Introduction: Use of highly effective antiretroviral drugs to eliminate new paediatric HIV infections is the keystone of all prevention of mother-to-child transmission (PMTCT) programmes. Time on antiretroviral treatment (ART) before delivery reduces maternal viral load and decreases the risk of …
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Seeing HIV through the eyes of perinatally infected adolescents living with HIV, on antiretroviral treatment
… independence, disclosure issues and adherence to antiretroviral treatment (ART) have become major concerns. However, research on how adolescents view and cope with these challenges remains limited, especially in Sub-Saharan Africa. We explored ADLHIV's understanding of their infection and its …
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Experiences of HIV postitive patients on antiretroviral treatement at Thulamela Municipality in the Vhembe District of Limpopo Province, South Africa
Antiretroviral treatment (ART) has improved the quality of people who are (human immune virus) HIV positive. They have been document to decrease the morbidity and mortality of people its introduction in the late 1990's. The study addressed the experiences of HIV positive patients in the Vhembe …
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The effect of antiretroviral treatment on HIV associated tuberculosis incidence and outcomes in the Free State Province, South Africa.
… 79% are in Sub-Saharan Africa. While scale-up of antiretroviral treatment (ART) is reducing mortality in the region, there is little direct evidence of the magnitude of its effect on mortality in people coinfected with TB, or on TB treatment outcomes. There is little evidence on the effect of ART …
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Pharmacogenetics of Efavirenz response in Bantu-speaking South African HIV/AIDS patients
Efavirenz (EFV) is used in first-line antiretroviral (ARV) therapy of HIV-infected patients, and is principally metabolised by CYP1A2, CYP2A6, CYP2B6, CYP3A4/5 and the drug transporter ABCB1. Genetic variability in the above genes may contribute to differences in EFV plasma concentrations which …
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Whole Blood Mitochondrial DNA Depletion in Human Immunodeficiency Virus-Infected Children
… HIV-infected, NRTI-treated and 62 HIV-infected treatment-naive children. Multivariate analysis was used to identify variables independently associated with mtDNA depletion. Results: Mean mt:nDNA ratios were lower (P < 0.001) at 77% of control in the HIVinfected antiretroviral treatment (ART) …
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Scaling up ART in Rwanda: the financial and economic costs
Rwanda has been rolling-out free antiretroviral treatment (ART) since 2004. This scale up could only be realised through significantly increased funding to the HIV/AIDS sub-account. Funding grew from US$9 million in 2003 to US$43 million in 2004 (UNAIDS, 2006b) and has continued to grow since this …
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Assessing access barriers to Tuberculosis (TB) and Antiretroviral (ARV) treatment in Mitchell's Plain, Cape Town South Africa
… access dimensions) to both Tuberculosis (TB) and Antiretroviral Treatment (ART) services in Mitchell's Plain, Cape Town South Africa. Secondary cross-sectional data was used for this purpose. Access to TB and HIV treatment has been given priority because the two diseases have had a massive and …
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“A case study evaluating the effectiveness of adherence clubs in Gugulethu as a strategy for mobilizing and engaging men in HIV treatment”
… shows that men living with HIV need efficient antiretroviral treatment (ART) delivery. Adherence clubs (ACs) have been identified as one way to improve retention of stable patients living with Human Immunodeficiency Virus (HIV). ACs are among several strategies that have been said to …
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The impact of stressful life events on antiretroviral treatment adherence and viral load amongst adults in Gugulethu, Cape Town
Optimal antiretroviral treatment (ART) adherence is critical in achieving virologic suppression. Most people living with HIV (PLWH) experience HIV-related challenges which may be compounded by the experience of stressful life events (SLE) with adverse effects on their ART adherence and therefore …
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Approaches for Handling Time-Varying Covariates in Survival Models
… the fitted models and it shows that choice of a particular model to fit is influenced by the aim and objectives of fitting the model. In 2002, an AntiRetroviral Treatment (ART) service was established in the Cape Town township of Gugulethu, South Africa. These models will be applied to an HIV/AIDS …
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Modeling Complex Neurological Disorders With Human Induced Pluripotent Stem Cells
… Disorders (HAND), are still unknown, partly due to a lack of accurate models. Human-induced pluripotent stem cells (HiPSCs), which can be differentiated into any cell type and capture the genetic variation across humans, may serve as a powerful model to elucidate the mechanisms behind …
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Challenges confronting professional nurses implementing the nurse-initiated and managed antiretroviral treatment programme in Vhembe District, South Africa
Antiretroviral treatment (ART) roll-out presents new opportunities and challenges for nurse-initiated-andmanaged antiretroviral treatment (NIMART) trained nurses in the primary health care (PHC) facilities. Nurses have had central role in the management of the human immunodeficiency virus (HIV) …
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Retrospective review of urinary lipoarabinomannan (ULAM) in the diagnosis of disseminated tuberculosis (TB) in medical inpatients at a district level hospital in Cape Town
… available in SA to expedite the diagnosis and treatment of Tuberculosis (TB) in this vulnerable population. Objectives To describe the experience at a district level hospital following the availability of ULAM testing for investigating HIV positive TB suspects. Firstly, to define the population …
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Strategies for optimising TB-HIV co-treatment in children and adolescents with drug-susceptible tuberculosis on rifampicin-based standard regimens
… tuberculosis (TB) and often require concurrent antiretroviral treatment (ART) and antituberculosis therapy. However, rifamycins, the key drugs for TB treatment, significantly interact with many ART classes, necessitating adjustments to one or both therapies. In African and other low-resource …
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How accurately do routinely reported HIV viral load suppression proportions reflect progress towards the 90-90-90 target in the population on ART in Khayelitsha, South Africa?
… but less than 56% completion on routine quarterly reports, casting doubt on the validity of reported suppression. Objectives: To assess the validity of reported VL suppression as a measure of progress towards the 90-90-90 target and identify barriers to routine VL completion. Methods: A …
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Treatment outcomes in perinatally-infected HIV positive adolescents and young adults after 10+ years on antiretroviral therapy
… vertical infections and success of paediatric antiretroviral treatment (ART) programmes in improving life-expectancy in perinatally HIV-infected (PHIV) children, the burden of paediatric HIV in SA has changed to older children. An increasing population of PHIV children on ART is reaching …
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Toxicities associated with antiretroviral treatment of HIV-1
Background: Despite the success of antiretroviral treatment (ART) in human immunodeficiency virus (HIV), the associated toxicities are complex to manage and compromise treatment benefits. Prevention and treatment of chronic toxicities such as cardiovascular disease (CVD), metabolic disorders, …
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Pharmacokinetics, pharmacogenetics and optimisation of treatment with non-nucleoside reverse transcriptase inhibitors in HIV-infected African children
… nevirapine are the most widely used agents for treatment of HIV in children. Sources of variability in their pharmacokinetics and its association with virological outcome and adverse events in African children are poorly characterised, thereby limiting treatment optimisation. To fill this gap we …
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A multi-state model of treatment states in an antiretroviral treatment programme cohort in Cape Town
… systematic review estimated that almost a quarter of patients in low- and middle-income countries are not retained on antiretroviral treatment (ART) beyond one year. Further, it is difficult to determine whether a patient who is not retained in care has interrupted their treatment, …
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