Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 151 for “"Antiproliferative"”.
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Antiproliferative Natural Products from the Madagascar Rainforest
… were selected for investigation based on their antiproliferative activity. Bioassay-guided fractionation of five of the extracts yielded sixteen new compounds, and their structures were determined using a combination of 1D and 2D NMR experiments, including COSY, HSQC/HMQC, HMBC, and ROESY/NOESY …
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Isolation and Structure Elucidation of Antiproliferative Natural Products from Madagascar
As part of an ongoing search for bioactive natural products from the endemic rainforests and surrounding ocean in Madagascar, a total of four extracts were comprehensively studied and were found to contain novel and/or bioactive compounds. The following dissertation discusses the isolation, …
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Isolation and Structure Elucidation of Antiproliferative Agents From Madagascar Rainforests
… All four compounds exhibited good antiproliferative activity on the A2780 bioassay. The fractionation of the extract of Grewia sp. led to the isolation of one new and one known triterpenoid. The known triterpenoid was identified as 7β-hydroxy-23-deoxojessic acid and its structure …
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Synthesis and Antiproliferative Activity of C3' and B-ring Modified Paclitaxel Analogs
The natural product, paclitaxel, has made tremendous contributions in supplying the arsenal of anticancer therapeutics, and was FDA approved for clinical use in 1992. In order to design simplified analogs, the conformation that paclitaxel adopts when binding to tubulin has been the subject of …
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Isolation and Structure Elucidation of Antiproliferative and Antiplasmodial Natural Products from Plants
… four plant extracts were investigated for their antiproliferative and antiplasmodial activities. With the guidance of bioassay guided fractionation, two known antiproliferative terpenoids (2.1 and 2.2) were isolated from Hypoestes sp. (Acanthaceae), four known antiplasmodial liminoids (3.1-3.4) …
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Design, synthesis and evaluation of amphibian isolated peptides as antibacterial and antiproliferative agents
With the emergence of antibiotic resistance, people are trying to find alternatives to the classic antibiotics. Antimicrobial peptides have captured the attention to be developed as novel antibiotic agents. These peptides were discovered with a broad spectrum of bioactivities. In this study, three …
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Differential Endometrial Responses of Primates vs Rodents: Screening for Antiproliferative Effects of Antiprogestins
… to identify the noncompetitive antiestrogenic/antiproliferative effects of mifepristone.</p> <p>Long-term ovariectomized monkeys were exposed to exogenous 17β-estradiol (E2) and mifepristone in doses and regimes already demonstrated to curtail endometrial growth (Wolf et al., 1989b). Results …
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Developmental Expression of Rat Target of the Antiproliferative Antibody (rTAPA) Protein in the Brain
<p>The present study defines the expression pattern of rTAPA (CD81) in the developing rat brain. rTAPA is a member of the tetramembrane spanning family of proteins, and like other members of this family, appears to be associated with the stabilization of cellular contacts. On immunoblots of the …
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Antiproliferative Activity of Carotenoids, Phenolic Compounds, and Volatile Terpenoids in Carrots (Daucus carota L.)
… objective of this study was to compare the antiproliferative effects of carotenoids, phenolics, and volatile terpenoids extracted from carrots on Caco-2 colon cancer cells in vitro. Briefly, carrot carotenoids, phenolics, and volatiles were extracted from carrots using liquid-liquid, solid …
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Isolation and characterisation of novel glycosaminoglycan-like polysaccharides derived from marine molluscs with antiproliferative activity
… and targeted therapy, newly developed drugs with antiproliferative/cytotoxic effects are still in demand; hence, newly discovered anticancer drugs with an improved pharmacological profile are needed to overcome drug resistance of cancer cells. This study focused on identifying and characterising …
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Lipoxygenase Activity in Diatoms : A New Tool to Study the Antiproliferative Effects of Diatoms on Copepod Reproduction
The deleterious effects of maternal diatom diets on copepod embryonic development have been puzzling the scientific community for the past 15 years. Since the discovery of the first anti-mitotic compounds, polyunsaturated aldehydes deriving from fatty acid oxidation,our knowledge of the oxylipin …
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Assessment of antimicrobial and antiproliferative activities of a bioactive peptide from the skin secretion of white-lined leaf frog
… resultant peptide was subject to antimicrobial, antiproliferative and haemolysis tests to ascertain its bioactivities. This peptide was found to exhibit antimicrobial activity against S. aureus, E. coli and C. albicans with MIC values of 2 µM, 2 µM and 64 µM, respectively. Also, this peptide …
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Antiproliferative activities of Euphorbia bicolor (euphorbiaceae) and Maclura pomifera (moraceae) extracts on estrogen receptor-positive and triple-negative breast cancer cell lines
… for cancer treatment. This study explores the antiproliferative properties and mechanisms of action of phytochemicals from two native plants, Maclura pomifera and Euphorbia bicolor, in breast cancer cell lines. Maclura pomifera, a dioecious tree native to the south-central USA, showed …
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Isolation and Structure Elucidation of Anticancer and Antimalarial Natural Products
… Group (ICBG) program and a continuing search for antiproliferative natural products from the Madagascar rainforest, and a collaborative research project established between Virginia Tech and the Institute for Hepatitis and Virus Research (IHVR) focusing on searching for bioactive natural products …
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Isolation, Synthesis and Structure-Activity Relationship Study of Anticancer and Antimalarial Agents from Natural Products
… As a part of this research, a total of four antiproliferative extracts were studied, leading to the isolation of fourteen novel compounds with antiproliferative activity against the A2780 human ovarian cancer line. One extract with antimalarial activity was studied, which led to the isolation …
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Structural Characterization and <em>in vitro</em> Antiproliferative Activity of Non-Specific Lipid Transfer Protein 1 (nsLTP1) from Fennel (<em>Foeniculum vulgare</em>) Seeds
… 3D structure modeling, and <em>in vitro </em>antiproliferative activity of nsLTP1 from fennel (<em>Foeniculum vulgare</em>) seeds.</p> <p>Fennel<em> </em>is a member of the family Umbelliferae (Apiaceae) native to southern Europe and the Mediterranean region. It is used as a spice, medicine …
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The role of Gai in the Gonadotropin-releasing hormone (GnRH) receptor inhibition of cell proliferation
… by the GnRH ligand has been shown to mediate antiproliferative effects in extra-pituitary cells and in reproductive cancer cell lines. The GnRHR couples to Gαq in pituitary gonadotropes. However, the GnRHR expressed in reproductive cancer cell lines is thought to couple to Gαi. Recent evidence …
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Isolation, Structure Elucidation, and Total Synthesis of Biologically Active Natural Products from Plants
… thirteen plant extracts were investigated for antiproliferative activity, and one extract was investigated for inhibitors of the shikimate pathway in Plasmodium falciparum. Bioassay-guided fractionation of the extracts led to the identification of nineteen compounds with both antiplasmodial and …
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Isolation and Structure Elucidation of Anticancer and Antimalarial Natural Products
… plant extracts were investigated for their antiproliferative and antimalarial activities. Bioassay guided fractionation of thirteen extracts led to the identification of three new antiproliferative compounds, ethyl leptaulosides A-C (5.1-5.3), six new antiplasmodial compounds, …
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DRUG ELUTING TISSUE ENGINEERED VASCULAR GRAFTS
… use of Drug eluting stents (DES), which contain antiproliferative agents that suppress the inflammatory process after implantation reducing the incidence of IH. This study evaluates the efficacy of using and synthesizing Drug Eluting Tissue Engineered Vascular Grafts (DETEVG) using a murine model …
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