Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Antiproliferation activity"”.
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Preservation of Bioactive Compounds in Blueberry Fruit
… and antioxidant, and evaluate how bioactivity changes when blueberries are incorporated into processed food products. A novel separation method was successfully developed that isolated high molecular weight proanthocyanidin oligomers from other simpler polyphenols while eliminating …
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Identification and functional study of the bioactive peptide QUB-2830 from the skin secretion of the blue-side leaf frog, Agalychnis annae
… QUB-2830 showed significant antimicrobial activity against a Gram-negative bacterium, Escherichia coli (E. coli ATCC CRM8739), a Gram-positive bacterium, Staphylococcus aureus (S. aureus ATCC CRM6538), and a yeast, Candida albicans (C. albicans ATCC CRM10231). For S. aureus, the minimum …
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Identification and evaluation of the bioactive peptide QUB-2925 from the defensive skin secretion of Phyllomedusa tomopterna
… inhibition of 80.1%. Also, it showed haemolytic activity with 8.5% haemolysis at 64 μM. In conclusion, QUB-2925 showed obvious antibacterial activity against E. coli, S. aureus and C. albicans at a non-haemolytic concentration and had strong antiproliferation activity against NCI-H838 cells. It …
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Design, Syntheses, and Bioactivities of Conformationally Locked Pin1 Ground State Inhibitors
… drug target, Pin1 interacts and regulates the activity of an increasing number of cell cycle enzymes by an unknown mechanism. These cell cycle enzymes include Cdc25, Cdc27, Cyclin D1, Myt1, Wee1, NIMA, Cdc2, Plk1 and c-Myc. Recent research has revealed that Pin1 is overexpressed in a variety of …
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Phytochemistry and biological studies of constituents from Breonadia Salicina (VAHL) Hepper and J. R. I. Wood
… stem bark, and leaf). In the antiplasmodial activity, three fractions collected in the first year affected the viability of Plasmodium falciparum, with viabilities of 16.16 ± 8.63 %, 27.01 ± 4.47 % and 31.07 ± 6.71 %; and IC50 values of 2.19 ± 0.09 μg/mL, 1.91 ± 0.05 μg/mL and 3.02 ± 0.08 …