Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Antiproliferation"”.
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Preservation of Bioactive Compounds in Blueberry Fruit
… tract infections. In an experiment comparing antiproliferation activity of wild and cultivated (Vaccinium corymbosum L.) blueberry fractions in LNCaP cells (androgen sensitive) to DU145 cells (androgen insensitive), LNCaP cell growth was dramatically reduced by three pro anthocyanidin-rich …
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Design, Synthesis and Biological Evaluation of Novel Estradiol-Triazole Analogs Targeting Epidermal Growth Factor Receptors in Colorectal Cancer
… were synthesized and biologically evaluated. Antiproliferation/cytotoxicity assay conducted on CRC cancer cell line (HT-29) showed that 5 out 14 analogs demonstrated potential antiproliferation activities ranging from 3.5 μM to 30 μM in comparison to a chemotherapeutic agent 5- flurouracil …
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Evaluation of bioactivity of a peptide QUB-1669, from the skin secretion of the African running frog, Kassina senegalensis
… a range of bioassays such as antibacterial, antiproliferation, haemolysis and smooth muscle. The results showed that QUB-1669 peptide had potent effects on rat ileum smooth muscle and uterine smooth muscle at low concentrations of 10-11M without lysing horse red blood cells. This peptide had …
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Effects of selenite on metabolic events during the proliferation of canine mammary tumor cells
… within CMT-13 cells increased. One of the antiproliferation effects of selenite on CMT-13 cells is accompanied by decreased rates of macromolecule synthesis, increased cellular macromolecule contents and increased cell size and multiple nuclei, indicating that enhanced cell fusion occurred. …
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Dissection of GnRH receptor-G protein coupling
… and the signalling cascades involved in inducing antiproliferation remain controversial. To delineate the G protein coupling selectivity of the mammalian GnRH receptor and to identify the signalling pathways involved in GnRH I-mediated cell growth inhibition, I examined the ability of the receptor …
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Identification and functional study of the bioactive peptide QUB-2830 from the skin secretion of the blue-side leaf frog, Agalychnis annae
… of the MTT assay, QUB-2830 was shown to have antiproliferation activity against NCI-H838 cancer cells at a concentration of 10-4 M. In a haemolysis assay, QUB-2830 showed haemolytic activity at concentrations between 16 ~ 128 μM. In summary, QUB-2830 exhibited a remarkable antimicrobial …
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Identification and evaluation of the bioactive peptide QUB-2925 from the defensive skin secretion of Phyllomedusa tomopterna
… at a non-haemolytic concentration and had strong antiproliferation activity against NCI-H838 cells. It may be optimised by modification and is expected to be a promising polypeptide drug.<br/><br/><i>Thesis embargoed until 31 December 2026</i>.
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Design, Syntheses, and Bioactivities of Conformationally Locked Pin1 Ground State Inhibitors
… its PPIase domain. The A2780 ovarian cancer cell antiproliferation activity of these peptidomimetics parallels their respective Pin1 inhibition data. This research provides a start toward more drug-like Pin1 inhibitor design. Gly–<i>trans</i>–Pro isosteres were synthesized using the …
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SYNTHESIS AND CHARACTERIZATION OF RESVERATROL AND ITS CONJUGATED METABOLITES AND CONTRIBUTION OF METABOLISM TO ITS DECREASED BIOVAILABILITY
… chrysin) on two chemoprevention endpoints - i) antiproliferation and ii) UGT enzyme induction. Our results indicate that resveratrol is capable of inducing UGT1A1 expression and activity in a non-concentration dependent manner and this induction as well as its antiproliferative effects are …
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Design, Synthesis and Biological Screening of Novel Cucsinspired Estrone Analogues Towards Treatment of Hepatocellular Carcinoma
… synthesis of novel CIEA analogs of potent antiproliferation/ anticancer activities toward hepatocellular carcinoma and potential application to overcome cancer resistance to current chemotherapeutic agents.</p>
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Identification and functional assessment of a bioactive peptide QUB-2984 from the skin secretion of the red-eyed tree frog, Agalychnis callidryas
Bioactive peptides secreted from amphibians have been studied broadly for their potency as alternative drugs to treat human diseases. This thesis is about a caerin-related peptide derived from red-eyed leaf frog, Agalychnis callidryas, which provided ideas for further antibiotic research. Herein, …
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Antiproliferative Activity of Carotenoids, Phenolic Compounds, and Volatile Terpenoids in Carrots (Daucus carota L.)
<p>Epidemiological studies have shown an association between high carrot consumption and low prevalence of cancer. This observation has been thought to be attributed to carrot carotenoids. Despite this, various intervention trials have displayed no changes in incidence or increased incidence of …
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Phytochemistry and biological studies of constituents from Breonadia Salicina (VAHL) Hepper and J. R. I. Wood
Breonadia salicina (Vahl) Hepper and J.R.I. Wood is a tree used widely to treat numerous infectious diseases in South Africa and other African countries, and ethnopharmacological studies have shown a number of biological activities of the crude extracts. Furthermore, phytochemical studies have …