Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 44 for “"Antiplasmodial activity"”.
-
The isolation, characterization and antiplasmodial activity of two novel dimeric sesquiterpenes from Dicoma anomala
The study investigates the antimalarial potential of a Southern African traditional medicinal plant, Dicoma anomala (Sond.). The plant is used to treat a variety of treatments including fevers. The extracts of the leaves and twigs have been reported to treat malaria and fever but the treatments …
-
Quinoline-triazole half-sandwich iridium(III) complexes: Synthesis, antiplasmodial activity and preliminary transfer hydrogenation studies
… an increasingly popular method of enhancing antiplasmodial activity in the drug-resistant parasite strains. Two series of 7-chloroquinoline-1,2,3-triazole ligands, one with the direct attachment of the triazole to the quinoline and one where the two entities are separated by an aminopropyl …
-
In Vitro Antiplasmodial activity and phytochemicals screening of ethnomedicinal plants used to treat Malaria associated symptoms
A thesis submitted in fulfillment of the requirement of the Degree of Master of Science.
-
Totarol as privileged natural product scaffold for antimalarial drug discovery
… scaffold “totarol", which possesses inherent antiplasmodial activity, was used to design and investigate the antiplasmodial activity of three different compound classes namely: Mannich bases, aminoalcohols and semicarbason derivatives. The aim was to incorporate important drug fragments into a …
-
Synthesis and biological evaluation of thiazole and metergoline derivatives as antimycobacterial and antiplasmodial agents
… scaffold. These derivatives exhibited moderate antiplasmodial activity in the CQS strain of P. falciparum, and good antimycobacterial activity on the H37Rv strain of M.tb. A 2-pyridyl group at position 4 of the thiazole ring as well as a substituted phenyl at position 2 was found to be essential …
-
Single and hybrid antimalarials based on artemisinin, chloroquine and ß-lactams : synthesis, antiplasmodial activity, cytotoxicity and effect of selected artemisinin-chloroquine hybrids on the parasitic endocytosis pathway
… reactions. The compound with the best activity from the series was used to couple these reactions to post-condensation chemical modifications via the Mannich reaction, another multi-component reaction, to create a more diversified library. A small series of 4-aminoquinoline analogues, …
-
Screening of actinobacteria for novel antimalarial compounds
… in the Meyers laboratory, were screened for antiplasmodial activity against drug-sensitive Plasmodium falciparum, NF54. Liquid cultures were extracted using the mid-polar solvent, ethyl acetate, with the aim of discovering drug-like molecules that can be administered orally. Thirty-one …
-
Investigation of selected Nigerian medicinal plants as a source of new antimalarial agents. Isolation of phytochemicals from some Nigerian medicinal plants using chromatographic techniques and their evaluation for antiplasmodial activity.
… in search of novel compounds with promising antiplasmodial activity. Using the ethnobotanical approach, a total of 61 plant species from 59 genera distributed in 34 plant families were found to be used traditionally for the treatment of malaria in Nigeria. Biological evaluation of the plant¿s …
-
Isolation and Structure Elucidation of Antiproliferative and Antiplasmodial Natural Products from Plants
… investigated for their antiproliferative and antiplasmodial activities. With the guidance of bioassay guided fractionation, two known antiproliferative terpenoids (2.1 and 2.2) were isolated from Hypoestes sp. (Acanthaceae), four known antiplasmodial liminoids (3.1-3.4) were isolated from …
-
Structure-activity relationship studies of 2-phenylbenzimidazoles and related organometallic complexes as antiplasmodial agents
… potential drug candidates, displaying potent antiplasmodial activity. Furthermore, benzimidazoles can be chemically transformed into metal-containing organometallic complexes that elevate generally flat benzimidazoles to the third dimension. To date, examples of metal-containing benzimidazoles …
-
Synthesis and profiling of antimalarial side-chain modified pyrido[1,2-a]benzimidazoles
… with novel mechanisms of action, multistage activity, good safety profiles and efficacy at low doses. To address this need, structure activity relationship (SAR) and structure property relationship (SPR) studies were carried out on a novel antimalarial chemotype, namely the …
-
Antimalarial Evaluation of Quinoline-triazoleMn(I) and Re(I) PhotoCORMs
… characterization and biological evaluation as antiplasmodial agents of two new quinoline-1,2,4-triazole ligands and their respective Mn(I) and Re(I) tricarbonyl complexes. The two ligands differ in the presence of an extended amino-propyl chain conjugated to the quinoline scaffold, which has …
-
Isolation, Structure Elucidation, and Total Synthesis of Biologically Active Natural Products from Plants
… thirteen plant extracts were investigated for antiplasmodial activity, thirteen plant extracts were investigated for antiproliferative activity, and one extract was investigated for inhibitors of the shikimate pathway in Plasmodium falciparum. Bioassay-guided fractionation of the extracts led …
-
Synthesis and investigation of quinoline based ß-haematin formation inhibitors as potential antimalarials
… hydrophilic substituent results in retention of antiplasmodial activity in the 4-aminoquinoline class of compounds was investigated...
-
Discovery and Delivery of Bioactive Natural Products
… ten plant extracts were investigated for their antiplasmodial activity against Plasmodium falciparum Dd2 strain. Twenty-eight compounds were isolated, and twelve of them were new compounds. The structures of all these compounds were determined by analysis of their mass spectrometric, 1D and 2D …
-
Isolation and Structure Elucidation of Anticancer and Antimalarial Natural Products
… ethyl leptaulosides A-C (5.1-5.3), six new antiplasmodial compounds, apoplanesiacarpan A and B (2.4-2.5), (±)-rhodomyrtosone F (3.1), (±)-calliviminone C (3.2), 3α-angeloyloxy-15-hydroxylabda-7,13-dien-16,15-olid-18-oic acid (4.1), 3α-angeloyloxy-15-methoxylabda-7,13-dien-16,15-olid-18-oic …
-
Antiplasmodial/Antipyretic activity of some Zulu medicinal plants
… antioxidant, in vivo antipyretic and in vitro antiplasmodial activities as well as the cytotoxicity of the nine plants. The study also aims to isolate and purify the active compound in the most active plant extract. Material and methods Plants obtained from the muti market were botanically …
-
Physicochemical, biological and β-haematin inhibiting activity of pyrido-dibemequines, pyrido[1,2-α]benzimidazoles and their derivatives
… and experimental methods. In addition, their antiplasmodial and antischistosomal activities were determined and correlated with their respective physicochemical properties. As regards mechanistic evaluation, their ability to inhibit formation of abiotic HZ, β-haematin (βH), was assessed and …
-
Development of quinoline and non-quinoline based organometallic complexes and their ligands conjugated to polyamine scaffolds as pharmacological agents
… also studied. The compounds were screened for antiplasmodial activity, in addition, their activity against WHCO1 oesophageal cancer cells and the parasite, Trichomonas vaginalis (T vaginalis) was also evaluated.
-
Antimalarials from Plant Pathogenic Fungi
… of eight fungal strains. In addition to the antiplasmodial assay, all the extracts were subjected to phytotoxic, antimicrobial, and cytotoxic bioassays. Isolation of metabolites was performed by chromatographic methods and identification was carried out by spectroscopic and spectrometric …
Page 1 of 3