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Showing 1 to 9 of 9 for “"Antiphospholipid syndrome"”.
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Earlier Detection of Antiphospholipid Syndrome
… was his valve the actual cause was discovered, antiphospholipid disorder. It was found that the patient had elevated anti-cardiolipin antibodies that caused the blood clot to form. The patient’s life as a whole is now altered completely due to a preventable thrombolytic event. His children also …
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Dissecting the Molecular Basis of the Antiphospholipid Syndrome
The antiphospholipid syndrome (APS) is an autoimmune disorder characterized by circulating antiphospholipid antibodies (aPL), thrombotic events, recurrent pregnancy loss, and increased risk of coronary artery disease. The endothelium is a critical direct target of aPL, which cause increases in …
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Evaluating Treatment of Antiphospholipid Syndrome during Pregnancy with Knowledge Synthesis Methods
Background: Pregnancies complicated by antiphospholipid syndrome (APS) are at an increased risk of adverse pregnancy outcomes, including recurrent miscarriage, stillbirths, placental insufficiencies and maternal thrombosis. APS during pregnancy remains a challenge, since these complications …
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Anticoagulant Treatment Effects Assessment in Antiphospholipid Syndrome Patients Using Targeted Learning and the Oracle Health EHR Data
<p>Antiphospholipid syndrome (APS) is a chronic autoimmune condition characterized by an increased risk of both arterial and venous blood clots, leading to significant health complications and even death. While warfarin has traditionally been the go-to anticoagulant for most patients with APS, many …
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Identification of Anti-Beta2 Glycoprotein I Auto-antibody Regulated Gene Targets in the Primary Antiphospholipid Syndrome Using Gene Microarray Analysis
… with thrombosis in patients with primary antiphospholipid syndrome (PAPS). Anti-2GPI activate endothelial cells (EC) resulting in a pro-thrombotic and pro-inflammatory phenotype. In order to characterise EC gene regulation in response to anti-2GPI, early global gene expression was …
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Identification and characterisation of cardiolipin autoantibodies
… human serum samples obtained from patients with antiphospholipid syndrome (APS) APS is a disorder with clinical manifestations that include venous and arterial thromboembolism, thrombocytopenia, recurrent spontaneous abortions, and possibly a variety of cardiac neurologic, dermatologic, and other …
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Apoptotic Cells, Anti-Phospholipid Antibodies, and Anti-Chromatin Antibodies in Autoimmunity
Antiphospholipid antibodies (APAs) are detected in various autoimmune diseases, such as antiphospholipid syndrome (APS) and systemic lupus erythematosus. In addition to their binding to negatively charged phospholipids, APAs often cross-react with other molecules. Their potential biological effects …
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Computational investigation of membrane proteins across species and functional classes
Membrane proteins play central roles in cellular communication, metabolism, and homeostasis, yet experimental characterization of their dynamic interactions with membranes remains highly challenging. In this dissertation, I implement advanced molecular dynamics (MD) simulation workflows to …