Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"Antineoplastic agents"”.
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DERIVATIVES OF 2-BENZYLIDENECYCLOHEXANONE AS POTENTIAL ANTINEOPLASTIC AGENTS
The aim of this research was to prepare some substituted 2-benzylidenecyclohexyl isothiocyanates, which would be screened against L-1210 lymphoid leukemia and the KB tumor. The first step in the synthesis involved the preparation of substituted (E)-2- benzylidenecyclohexanones, which are …
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Synthesis and evaluation of hybrid compounds based on antimalarial and anticancer pharmacophores
… emergence of drug resistance, new antimalarial agents are needed to circumvent this. Similarly, in the treatment of cancer, there is an urgent need for the design and development of new antineoplastic agents. This work describes the design, synthesis and biological evaluation of …
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CYTOTOXIC EVALUATION OF SOME MANNICH BASES OF CONJUGATED STYRYL KETONES
… treatment. The major disadvantage of using antineoplastic agents is their lack of selective toxicity between normal and malignant cells. In addition, over a long period of time, carcinogenicity, mutagenicity and resistance may develop. These problems necessitate the development of new …
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DEVELOPMENT OF A NANOPARTICLE-BASED PLATFORM FOR THE DELIVERY OF THERANOSTIC AGENTS TO TUMOR TISSUE: TOWARD CLINICAL TRANSLATION
The selective delivery of anticancer agents to tumor tissue remains a major challenge in oncology, as many clinically effective drugs are limited by poor tumor specificity and dose-limiting systemic toxicity. Previous studies from the laboratory have explored the use of tumor-derived and …
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Identification & characterization of natural and synthetic compounds as new anticancer agents
… natural or synthetic compounds as new antineoplastic agents. The results obtained are divided according to the research topics addressed: Anticancer activity of new Phenanthroline compounds (Part I); The garlic compound Z-ajoene as anticancer agents (Part II). Studies referring to the …
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Importância da atenção farmacêutica na adesão ao tratamento com anastrozolem um hospital oncológico de João Pessoa-PB
… and the most common among women. The use of oral antineoplastic agents have been shown to decrease the risk of recurrence and mortality, and therefore, adherence to treatment is critical to achieve the expected results. This study aims to evaluate the importance of pharmaceutical care in treatment …
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SYNTHESIS OF a,ß-UNSATURATED-1,3-DIKETONES AND RELATED MANNICH BASES FOR EVALUATION AGAINST VARIOUS NEOPLASMS
… the potentiality of some of these compounds as antineoplastic agents. Based on kinetic and physicochemical considerations resulting from these studies, the synthesis of a number of Mannich bases derived from some substituted 3-arylmethylene-, 3- heteroarylmethylene- and 3-aralkenylmethylene …
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MANNICH BASES DERIVED FROM STYRYL ALKYL KETONES AND THEIR HYDRAZONE ANALOGS AS POTENTIAL ALKYLATING AGENTS
… classes of drugs are used. Of these, alkylating agents constitute about 30%. Today a few of the less common cancers can be effectively treated by chemotherapy or adjuvant therapy but the majority of the cancers cannot be treated satisfactorily. The drugs that are in clinical use are marked by …
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Metabolic, biochemical and molecular profiling of Catharanthus roseus flower cultivars and transformed hairy roots for monoterpenoid indole alkaloid accumulation /
… different cancers. Therefore, procurement of the antineoplastic agents is difficult but essential procedure. Alternatively, CatharanthllS tissue cultures have been investigated as a source of these agents; however they do not produce vindoline, which is an obligate precursor to vinblastine and …
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Tumor Cell Glutathione Metabolism: Therapeutic Implications
… lactones (SLs), a class of sulfhydryl-reactive antineoplastic agents, was evaluated. SLs are potent depletors of cellular GSH. Prompt resynthesis of GSH is a critical component of tumor cell recovery following exposure to SLs. Cytolysis by SLs was augmented by inhibition of GSH synthesis with …
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Synthesis and biological evaluation of potential DNA cross-linking agents based on pyrrolizidine alkaloids
DNA cross-linking agents represent one of the most potent categories of antitumor agents. Pyrrolizidine alkaloids are an abundant class of biologically active natural products. These alkaloids display high levels of DNA cross-linking ability, and could have potential use as antitumor agents. …
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UHRF1 and the DNA Damage Response
… threat from endogenous and exogenous damaging agents. Our cells have evolved a network of signaling pathways and repair mechanisms that detect and counteract this threat, collectively referred to as the DNA damage response. Cells that lose the ability to cope with DNA damage risk the …
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The synthesis of derivatives of naturally occurring naphthalenes
… structurally defined as bioreductive alkylating agents have considerable potential as antineoplastic agents, according to H.W. Moore (Science, 1977). The protoaphins possess certain structural features which suggest their capability to function as such alkylating agents. Reductive cleavage of the …
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PRECLINICAL PHARMACOKINETIC AND PHARMACODYNAMIC EVALUATION OF NEW ANTICANCER AGENTS FOR BRAIN TUMOR CHEMOTHERAPY
… the need for developing effective therapeutic agents. Styryl sulfones belong to a class of non-ATP competitive antineoplastic agents in early stage clinical trials. Detailed investigation of the pharmacokinetics (PKs) and pharmacodynamics (PDs) of novel agents in the preclinical stage plays a …
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Anti-Angiogenic Therapy in Non-Small Cell Lung Cancer: Characterizing a New Therapy and Investigating Potential Mechanisms of Resistance
Angiogenesis is the development of blood vessels from a pre-existing vascular network. This process is essential during growth, development and wound healing and plays a critical role in the growth and progression of cancer. Initial tumor size is restricted by the diffusion capacity of oxygen and …
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Enantioselective Total Synthesis of the Kibdelones
The kibdelones are a family of aromatic polyketides reported in 2006 by Capon and co-workers. These compounds possess potent antibiotic and cytotoxic activities and operate via an unknown and potentially unique mode of action. In order to fully investigate these properties the kibdelones were …
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Novel Small Molecule Induces Apoptosis in Malignant Peripheral Nerve Sheath Tumors of Neurofibromatosis Type I
Neurofibromatosis Type 1 (NF1) is an autosomal disease that affects neural crest-derived tissues, leading to a wide spectrum of clinical presentations. Patients commonly present with plexiform neurofibromas, benign but debilitating growths that can transform into malignant peripheral nerve sheath …
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Design and synthesis of dihydronaphthalene vascular disrupting agents and indolequinone-based bioreductives.
… of anticancer research, vascular disrupting agents (VDAs) that preferentially target the tumor vasculature show great promise. The naturally occurring combretastatins, especially combretastatin A-4 (CA4) and combretastatin A-1 (CA1), in suitable prodrug form, have proven to be highly …
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Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells
… therapies, or conventional chemotherapeutic agents. We used a highly annotated panel of more than 80 NSCLC cell lines to develop the most comprehensive database of cancer cell metabolism to date. These cell lines were analyzed for a set of ~100 metabolic parameters derived from nutrient …
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