Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 98 for “"Antineoplastic"”.
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Geroprotective and antineoplastic functions of protein homeostasis
La homeostasis proteica, o proteostasis, comprende una compleja red molecular encargada de mantener la estabilidad del proteoma, controlando la conformación, localización y concentración de proteínas dentro de las células. Su alteración afecta al correcto funcionamiento de las células y está …
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Monitoring of occupational exposure to antineoplastic drugs
Antineoplastic drugs are commonly used in the medical treatment of cancer and some other diseases. Workplaces e.g. hospital pharmacies and wards where antineoplastic drugs are used are contaminated with these drugs and health care workers are therefore at risk of getting occupationally exposed. …
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DERIVATIVES OF 2-BENZYLIDENECYCLOHEXANONE AS POTENTIAL ANTINEOPLASTIC AGENTS
The aim of this research was to prepare some substituted 2-benzylidenecyclohexyl isothiocyanates, which would be screened against L-1210 lymphoid leukemia and the KB tumor. The first step in the synthesis involved the preparation of substituted (E)-2- benzylidenecyclohexanones, which are …
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An investigation into the antineoplastic potential of Bridelia Micrantha Constituents
… this study. Special reference has been made to antineoplastic (cancer-combating) compounds derived from botanicals. Bridelia micrantha is a multipurpose tree used crudely by several African cultures for the treatment of a variety of ailments. Suggestive cytotoxic results attained from a …
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Increased Geranylgeranylated K-Ras Contributes to Antineoplastic Effects of Farnesyltransferase Inhibitors.
… increased activity of GG’d K-Ras contributes to antineoplastic effects from FTI by increasing the activity of downstream MAPKs.</p> <p>Our observations suggest increased GG’d K-Ras activity, rather than inhibition of farnesylated Ras, is a major source of the cytostatic and cytotoxic effects of …
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An investigation into the antineoplastic properties of Schinziophyton Rautanenii and Colophospermum mopane
Cancer incidences are on the rise in Namibia, because of late diagnosis, cancer cases often have poor prognosis and treatment options are limited especially in resource poor rural settings. Ethnomedicinal plants present a treatment option which is used in such settings, is accessible and …
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A study of selected antineoplastic, antibiotic, and corticosteroid drugs in intravenous admixtures
<p>The benefits of intravenous therapy have become more and more apparent over the years. Medications can be given rapidly with an expectant rapid onset of action. The response to the drugs or fluids can often be closely controlled by regulating the dose or rate of administration. Frequently, …
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An exploration of the patients' lived experience with antineoplastic medicines for colorectal cancer in Malta.
… being the third most common cancer worldwide. Antineoplastic medicines are considered the backbone of treatment for colorectal cancer, administered with the intent to relieve symptoms and achieve cure or prolong life. Consequently, patients have to cope with the burden of this treatment in …
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Biochemical, computer, and spectroscopic techniques applied to the study of prions and of combinations of antineoplastic drugs
… compounds, i.e. cis-platinum (CDDP), a potent antineoplastic used in the therapy of some types of carcinoma, with Cu(II) complexes that were previously shown to be endowed with potent cytotoxic activity in vitro (Pivetta et al., J Inorg Biochem. 2011 and 2012). Binary combinations comprising …
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The Effects of Methotrexate on Rat Parotid and Submandibular Glands and Their Secretions (Antineoplastic, Protein, Salivary, Amylase Catecholamines)
Experimental animals were injected intraperitoneally with methotrexate (15 mg/kg) for 3 days. Parotid and submandibular main ducts were cannulated and saliva flow was evoked by either intravenous infusion of acetylcholine (10 to 100 (mu)g/min) or an intravenous injection of bethanechol (100 …
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CYTOTOXIC EVALUATION OF SOME MANNICH BASES OF CONJUGATED STYRYL KETONES
… treatment. The major disadvantage of using antineoplastic agents is their lack of selective toxicity between normal and malignant cells. In addition, over a long period of time, carcinogenicity, mutagenicity and resistance may develop. These problems necessitate the development of new …
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The mechanism of action of tumour necrosis factor-α / Jeffrey A.J. Barbara.
… of Tumour Necrosis Factor-alpha as an antineoplastic agent has been severely restricted by dose-limiting side effects. Human TNF mutants with selective binding to the Human TNF receptors were employed to examine the role of these receptors in the mediation of TNF's cytotoxic and …
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Synthesis and evaluation of hybrid compounds based on antimalarial and anticancer pharmacophores
… need for the design and development of new antineoplastic agents. This work describes the design, synthesis and biological evaluation of chromone-aminoquinoline hybrids as potentially new chemotherapeutic agents.
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Avaliação da prescrição médica na pediatria de um hospital oncológico do estado da Paraíba : elaboração de um guia farmacoterapêutico para promoção do uso racional de antineoplásicos
… the state of Paraiba, determining the class of antineoplastic, analyzing compliance with current regulations of chemotherapy was used 236 prescriptions for c hildren 0 - 12 years that were filed in Napoleon Hospital Laureano, for the period from January to May 2015. Most users, 55% correspond to …
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DERIVATIVES OF 1-PHENYL-1-NONEN-3-ONE AS POTENTIAL BIOLOGICAL ALKYLATING AGENTS
The-preparation, spectroscopic properties and antineoplastic activities of a series of alkyl styryl ketones are presented. Unsaturated ketones are known to have alkylating properties. 1-Phenyl-1-nonen-3-one (51) and nuclear substituted derivatives were prepared as potential biological alkylating …
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ΚΒΑΝΤΟΧΗΜΙΚΗ ΚΑΙ ΠΕΙΡΑΜΑΤΙΚΗ ΜΕΛΕΤΗ ΤΗΣ ΔΟΜΗΣ ΚΑΙ ΤΩΝ ΦΑΙΝΟΜΕΝΩΝ ΥΠΕΡΑΝΤΑΛΛΑΓΗΣΝΕΩΝ D9 ΜΑΓΝΗΤΙΚΩΝ ΣΥΣΤΗΜΑΤΩΝ ΤΟΥ ΦΘΑΛΙΚΟΥ ΚΑΙ ΙΣΟΦΘΑΛΙΚΟΥ ΟΞΕΟΣ
… DATA, AND EHMA CALCULATION. FINALLY, THE ANTINEOPLASTIC ACTIVITY OF THE TWO DIEN COMPLEXES HAS BEEN EXAMINED, AS WELL.
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Theranostic applications of fluorescent liquid crystalline nanoparticles
… design of lipid nanoparticles able to deliver antineoplastic drugs and imaging probes for fluorescent optical in vitro and in vivo imaging. We developed cubosome formulations loaded with antineoplastic drugs and useful for the fluorescence imaging of cells. Such formulations were also actively …
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Leveraging copper chelators as targeted therapy for BRAFV600E mutant thyroid cancer
… drugs. Consistent with TM deriving its antineoplastic activity by inhibiting MEK1/2, expression of activated ERK2, a substrate of MEK1/2, overcame the ability of TM to suppress growth of BRAFV600E-mutant PTC cells. TM was also effective in a genetically engineered mouse model of …
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Metabolic Manipulation of Glutathione as an Anticancer Therapeutic Target
… growth. The primary mechanism for promoting antineoplastic effects in response to palmitoylcarnitine is through oxidative stress, namely through production of superoxide and subsequently hydrogen peroxide (H2O2). However, H2O2 can be hormetic in nature, whereby elevated H2O2 can result in …
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