Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 43 for “"Antimycobacterial activity"”.
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Metagenomic guided isolation of sporoactinomycetes from soil and screening for antimycobacterial activity
… of the 42 isolates studied were screened for antimycobacterial activity against Mycobacterium aurum strain A+ on four different media. A total of 35 strain-medium combinations (from 25 different strains) showed strong or very strong antimycobacterial activity. These 35 strain-medium …
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Antimycobacterial activity of the red algae gelidium pristoides, plocamium corallorhiza and polysiphonia virgata
… Terrestrial plants have been investigated for antimycobacterial activity, while marine plants are yet to receive as much attention. In this project, three South African marine plants were drawn into the search for novel anti-tuberculosis compounds. One of the seaweeds is already part of the …
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Analysis of actinobacterial biodiversity in reservoir sediment and cave soil and screening of isolates for antimycobacterial activity
… the Silvermine Nature Reserve were screened for antimycobacterial activity against the non-pathogenic Mycobacterium aurum strain A+ using a standard over-lay method. A total of five identified 2 actinobacterial isolates (Streptomyces strains RS6, RS7, RS9, RS13 and RS15) and an unidentified …
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Synthesis and biological evaluation of thiazole and metergoline derivatives as antimycobacterial and antiplasmodial agents
… derivatives exhibited moderate antiplasmodial activity in the CQS strain of P. falciparum, and good antimycobacterial activity on the H37Rv strain of M.tb. A 2-pyridyl group at position 4 of the thiazole ring as well as a substituted phenyl at position 2 was found to be essential for …
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Synthesis, characterisation, structure-activity and structure-property relationship studies of quinazolinones as antimycobacterial agents
… antibacterial and anti-tubercular activity. Within the context of work undertaken in this MSc dissertation, 2-aminoquinazolinones with promising antimycobacterial activity were identified from previous work in our research group. However, low aqueous solubility was associated with …
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Automated synthesis and evaluation of potential new anti-microbial agents
… Mycobacterium fortuitum in a rapid screen for antimycobacterial activity. Many of the compounds from this series were also tested against Mycobacterium tuberculosis, and the usefulness as M.fortuitum as a rapid, initial screen for anti-tubercular activity evaluated. Various deletions were made …
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Production of diospyrin by Euclea natalensis seedlings and in vitro cultures
… extracts of E. natalensis seedling organs showed antimycobacterial activity against Mycobacterium aurum, and HPLC analysis of the extracts demonstrated a corresponding accumulation of diospyrin, mostly in the stem (0.23%, DW) and roots (0.17%, DW) of the seedlings.
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Exploring the molecular diversity and biomedicinal potential of marine invertebrates and South African actinomycetes for tuberculosis drug discovery
… were therefore studied for the discovery of new antimycobacterial NPs. Several organic and aqueous marine invertebrate extracts were screened for their in vitro inhibitory activity against the Mtb strain H37Rv. The chemical components of two out of 54 active extracts were dereplicated using 1H …
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Synthesis and evaluation of D-cycloserine analogues against mycobacterium tuberculosis
… prodrugs. In an effort to explore structure-activity-relationships, a total of 17 compounds were synthesized, fully characterized, and evaluated in vitro for their antimycobacterial activity against the drug-susceptible Mtb H37Rv strain cultured in 7H9/ADC media. Of these, two compounds …
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Analysis of Actinobacterial Biodiversity in Marine Sediment from Gericke's Point (South Africa) and Screening of Isolates for Novel Antimycobacterial Compounds
… isolates (29 strains in total) were screened for antimycobacterial activity against the non-pathogenic Mycobacterium aurum strain A+ using a standard agar overlay method. To investigate their spectrum of antibiotic activity, all isolates were also screened for activity against Escherichia coli …
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An assessment of Hypoxis hemerocallidea extracts, and actives as natural antibiotic, and immune modulation phytotherapies
… objective of this study was to investigate the antimycobacterial activity of Hypoxis hemerocallidea, a South African medicinal plant, using Mycobacterium smegmatis.
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Synthesis, structure-activity relationship and solubility profiling of antimycobacterial aminoquinazolinones
… there is therefore a need to develop novel antimycobacterial agents to address these limitations. Within this context, 2-aminoquinazolinone compounds with potent antimycobacterial activity were previously identified. Poor solubility was recognized as a major issue requiring improvement. To …
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Transition Metal Complexes of Novel Phenanthroline Derivatives and their Antibacterial Activity
… point, displayed an increase in antibacterial activity of the ligand and its Cu(II) complex. The Ag(I) complex was the most active towards the fungal strain. The compounds tested did not display promising activity towards the Gram-negative bacterial strain. All compounds tested were well …
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Screening environmental actinobacteria for antimycobacterial antibiotics and characterisation of Kribbella stellenboschensis sp. nov
… morphology. These isolates were screened for antimycobacterial activity against the test bacterium Mycobacterium aurum A+. A Kribbella strain, isolated and identified by an intern in the lab, and a Micromonospora strain, isolated and identified during the authors Honours project, were also …
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Syntéza a hodnocení potenciálních antimykobakteriálních látek odvozených od hydrazinu
… two similar series of compounds with potential antimycobacterial activity. First series based on isoniazid are (E)-4-[(2- isonicotinoylhydrazineylidene)methyl]-N-phenylbenzamides with great activity (MIC for Mtb. of 0.03-0.125 μM) with few derivatives with moderate activity on nontuberculous …
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Antimycobacterial 2-aminoquinazolinones and benzoxazole-based oximes: synthesis, biological evaluation, physicochemical profiling and supramolecular derivatization
… for each of these classes with low micromolar antimycobacterial activity had previously been identified through phenotypic whole-cell in vitro screening.
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Investigating the chemical diversity and biomedicinal potential of South African actinomycetes for tuberculosis drug discovery
… Culture conditions were optimised for antimycobacterial activity of S. speibonae PK-BlueT extracts by testing against the MTB analogue Mycobacterium aurum A+ (a non-pathogenic, fast-growing mycobacterium that has a similar antibiotic susceptibility to Mycobacterium tuberculosis). …
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Antimycobacterial, docking and molecular dynamic studies of pentacyclic triterpenes from Buddleja saligna leaves
… and was confirmed to possess significant antimycobacterial activity when tested against Mycobacterium smegmatis, M. tuberculosis H37Rv (ATCC 25177), clinical isolates of multi-drug-resistant M. tuberculosis (MDR-TB) and extensively drug-resistant M. tuberculosis (XDR-TB) using the Micro …
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The application of the Multi-Component Reaction (MCR) strategy in the design and synthesis of new antiplasmodial and antimycobacterial agents
… which exhibit in vitro antiplasmodial and antimycobacterial activity.
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Cytotoxicity and anti-mycobacterial activities of sclerocarya birrea and Dodonae viscosa anguistifolia against MTB strain
… this study was to determine the cytotoxicity and antimycobacterial activities of Sand Olive and Marula. Methodology: The leaves (L) and barks (B) of Dodonaea Viscosa Anguistifolia (DVA or D) and S. birrea (S) plants were collected in the Vhembe district, Limpopo. Separate macerations in methanol …
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