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Showing 1 to 3 of 3 for “"Antimutator"”.
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Directed evolution of antimutator E. coli
… stability and examine previously characterized antimutators. Chapter 2 describes the first iteration of a directed evolution method used to engineer antimutators in Escherichia coli, Periodic Reselection for Evolutionarily Reliable Variants (PResERV). In this first PResERV experiment, I observe …
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Isolation of antimutator yeast strains: an exploration of DNA replication fidelity
… of eex mutations, respectively, encoded 'antimutator' polymerases that increased replication fidelity. The locations of antimutator amino-acid changes and their effects on mutation spectra suggest multiple mechanisms of mutator suppression. The remaining eex alleles were extragenic to the …
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Evolutionary Instability Of Genomic Mutation Rate In Rapidly Adapting Asexual Mutator Escherichia Coli Populations
… population exhibited apparent fixation for an antimutator. Some of the sequenced clones with altered mutation rates had mutations in known (anti)mutator loci. I conclude that the mutators likely arose by hitchhiking and that the antimutators likely confer pleiotropic direct fitness benefits. …