Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 104 for “"Antimicrobial peptides (AMPs)"”.
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DE NOVO DESIGN OF ANTIMICROBIAL PEPTIDES FOR APPLICATION AS ANTI-INFECTIVE AGENTS
Antimicrobial peptides (AMPs) have gathered considerable interest as a new source of antibiotics to tackle the escalating threat of antimicrobial resistance. Adopting a de novo approach enables the rational design of short synthetic AMPs, whilst mitigating concerns of resistance development to …
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Protective and Anti-inflammatory Effects of Protegrin-1 on Citrobacter rodentium Intestinal Infection in Mice
… millions of humans and food-animals world-wide. Antimicrobial peptides (AMPs) and their broad-spectrum antimicrobial activity represent a valuable potential therapeutic solution. Specifically, the potent pig-originated protegrin-1 (PG-1) has previously been shown to reduce the pathological …
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The expression and regulation on antimicrobial peptide genes in insects: studies in the tobacco hornworm manduca sexta
… humoral responses is the induced production of antimicrobial peptides (AMPs). In D. melanogaster, bacterial peptidoglycan (PG) and fungal beta-1,3-glucan can induce AMP production by activating the Toll and the IMD (immune deficiency) pathway. Chapter 1 reviews the key features of insect innate …
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Identification, isolation and bioactivity assessment of a novel peptide from the skin of Heilongjiang Brown Frog (Rana amurensis)
… substance form skin secretions, various peptides or proteins, was considered as treasures in medical treatment. The mechanism of antimicrobial peptides (AMPs) on antimicrobial activities was different from antibiotics and AMPs exhibit considerable value against antibiotic …
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The discovery of a novel bioactive peptide, QUB-1036, from the defensive skin secretion of Pelophylax kl. esculentus
Gene-coded antimicrobial peptides (AMPs) are a great source of natural antimicrobial agents and good models for the design of new generation antibiotics. In the meantime, a large number of AMPs have been isolated and characterised from different amphibian species due to their special skin structure …
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QUB-1453: A Bioactive Peptide from the Defensive Skin Secretion of Rana amurensis
… skin secretion is one of the richest sources for antimicrobial peptides (AMPs) which have potent bioactivity and pharmaceutical value for new drug development. In this thesis, QUB-1452, an AMP, was isolated and characterised from the skin secretion of Rana amurensis. The peptide is composed of 13 …
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Engineering membrane-selective antibiotic peptides to combat multidrug resistance
… new drug development strategies. Natural antimicrobial peptides (AMPs) have been long-recognized as a potential source of bacteriolytic drugs, but the shortcomings of non-specific membrane toxicity, proteolytic instability, and in vivo toxicity have stymied their clinical translation. …
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A bioactivity peptide QUB2852 from the frog skin secretion of pelophylax nigromaculata
Due to the resistance of antibiotics, antimicrobial peptides (AMPs) become research hotspot. Majority of AMPs can disrupt the cell membrane of microorganisms, leading to the death of microorganisms. In this study, the AMP QUB-2852 was identified from the skin secretion of pelophylax nigromaculata …
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Investigation of peptide-lipid interaction by fluorescence correlation spectroscopy
In this study a series of antimicrobial peptides (AMPs) called modified V4 (MV4s), was designed to have better solubility compared to original V4, which originated from a LPS-binding motif. The interaction between MV4s and different lipid model membranes was investigated using fluorescence …
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Motif discovery in sequential data
… I use grammatical models to design novel antimicrobial peptides (AmPs). AmPs are small proteins used by the innate immune system to combat bacterial infection in multicellular eukaryotes. There is mounting evidence that these peptides are less susceptible to bacterial resistance than …
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The production, design and application of antimicrobial peptides
… existing antibiotics are losing their potency. Antimicrobial peptides (AmPs) represent an exciting class of drug candidates, particularly because their mechanism of action is unlikely to induce drug resistance. If resistance to AmPs were also slower to emerge in the clinic, they would have …
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QUB-2577: A Bioactive Peptide from Pickerel Frog (Rana palustris) Skin Secretion
… secretion of frogs contains a large number of antimicrobial peptides (AMPs) and they are considered as a promising source of antibiotic alternatives.<br/>In this thesis, the peptide QUB-2577 was identified by "shotgun" cloning of precursor-encoding cDNA derived from the skin secretion of Rana …
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Studies on a bioactive peptide QUB-2044 from the skin secretion of the Chinese frog, Odorrana schmackeri
… So far, a great number of pharmacological and antimicrobial peptides (AMPs) have been successfully isolated and identified from the skin and associated secretions of amphibians. Furthermore, some of these peptides have been recognised as significant novel drug leads.<br/><br/>This thesis …
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The discovery of a novel peptide, QUB-2023, from Rana amurensis
The abundant antimicrobial peptides (AMPs) discovered in amphibian skin secretions have raised the interest of many researchers not only because of their broad spectrum of actions against many clinically-relevant microorganisms but also their superiority over conventional antibiotics.<br/><br/>This …
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A novel bioactive peptide from the defensive skin secretion of Phyllomedusa sauvagii
… activities. The research and exploitation of the peptides in amphibian skin secretions with antimicrobial or haemolytic activities has become increasingly popular. Many studies show that the antimicrobial peptides (AMPs) collected from amphibians have pharmacological and clinical …
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Regulation of Antimicrobial Peptide Genes in Insects by the Toll Pathway and NF-kB Transcription Factors
… on the other hand include production of antimicrobial peptides (AMPs) by fat body, which is equivalent to mammalian liver, prophenoloxidase, lectins and compliment-like factors. Chapter 1 talks about the important features of insect innate immunity. Chapter 2 discusses the role of the …
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A novel bioactive peptide from the skin secretion of Rana chensinensis
… antibiotic resistance situation is severe, and antimicrobial peptides (AMPs) have become a new research topic for solving the issue of antibiotic resistance. In addition, AMPs have also shown remarkable anti-cancer effects. It is, therefore, important to look for promising alternatives to …
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Polyelectrolyte multilayers for tunable release of antibiotics and other therapeutics
… of antibiotics, ranging from aminoglycosides to antimicrobial peptides (AmPs), were fabricated and characterized; these coatings are intended for applications onto biomedical device surfaces for infection control. In vitro efficacy against Staphylococcus aureus and nontoxicity towards …
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QUB-1439: A bioactive peptide from the frog skin secretion of Hylarana guentheri
Antimicrobial peptides (AMPs) are a sufficient and diverse group of molecules that are derive from various invertebrate, plant and animal species. AMPs possess a variety of biological activity, such as anticancer, antivirus and so on. Nowadays, a growing number of AMPs are considered as promising …
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The discovery and functional study of a novel bioactive peptide, QUB-2561, from the defensive skin secretion of the Central American red-eyed leaf frog, Agalychnis callidryas.
Peptides are short amino acid chains with multiple bioactivities. Compared with other small molecular drug candidates, peptides are highly specific and not easy to induce side effects. Many antimicrobial peptides (AMPs) have been found in frog skin epidermal secretions, which usually have …
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