Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 270 for “"Antimicrobial peptides"”.
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Novel Endogenous Antimicrobial Peptides
Antimicrobial peptides serve as a first line of defence against invading microorganisms and are an essential part of our fast innate immune system. They are ancient molecules found in all classes of life. Antimicrobial peptides rapidly kill a broad spectrum of microbes and are immunomodulatory, …
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ANTIMICROBIAL PEPTIDES FOR A SUSTAINABLE AGRICULTURE
L'agricoltura moderna si basa principalmente sull'utilizzo di pesticidi chimici per proteggere le colture da patogeni e parassiti. Tuttavia, l'uso massiccio di questi composti ha portato all'insorgenza di ceppi resistenti, all'inquinamento ambientale e al danno agli organismi non bersaglio. Per …
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Lysin Based Antimicrobial Peptides Against Acinetobacter Baumannii
… synergistically with polymyxin B. While the peptides were shown to kill by disrupting the bacterial cytoplasmic membrane, they did not lyse human red blood cells or B cells; however, serum was found to be inhibitory to lytic activity. In a murine model of A. baumannii skin infection, …
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Total Synthesis of Naturally Occurring Antimicrobial Peptides
… natural product, exhibiting potent antimicrobial activity against highly resistant Gram-positive pathogens such as methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococci (VRE), and several species of Streptococci. Previous chemoenzymatic synthesis, …
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Delivery, design, and mechanism of antimicrobial peptides
… The work described in this thesis develops new antimicrobials strategies against bacterial infections, focusing on antimicrobial peptides (AmPs). We first delivered genes inducing the toxic expression of AmPs and other lytic agents directly into bacteria using re-engineered bacteriophages. …
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Expression of antimicrobial peptides in human lung tissue
Lunga mannsins er mjög flókið líffæri sem er samansett af pípulaga líffærakerfi sem tengist andrúmsloftinu í gegnum öndunarveginn. Í lunganu eiga sér stað loftskipti á súrefni og koltvíoxíði og þarf lungað því að hafa vel skipulagt ónæmiskerfi. Þegar lofti er andað inn í lungun fylgja mikið magn af …
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STRUCTURAL, FUNCTIONAL AND EVOLUTIONARY STUDIES OF ANTIMICROBIAL PEPTIDES
Antimicrobial peptides represent a heterogeneous group that displays multiple modes of action such as bacteriostatic, microbicidal and cytolytic properties that are sequence and concentration dependent. Life threatening infectious disease is now a worldwide crisis and treating them effectively is …
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The production, design and application of antimicrobial peptides
… existing antibiotics are losing their potency. Antimicrobial peptides (AmPs) represent an exciting class of drug candidates, particularly because their mechanism of action is unlikely to induce drug resistance. If resistance to AmPs were also slower to emerge in the clinic, they would have …
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TARGETING MULTI-DRUG RESISTANT PATHOGENS WITH NOVEL ANTIMICROBIAL PEPTIDES
The emergence of antibiotic resistance is a notorious problem worldwide. In the United States alone, antibiotic-resistant bacteria infect at least two million people and kill around 23,000 patients each year. Half of these infections are attributed to the bacterial pathogen, methicillin resistant …
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Actions of Antimicrobial Peptides and Bacterial Components in Inflammation
Antimicrobial peptides are evolutionally ancient parts of the innate immune system and their primary role is to protect us from infections. The human cathelicidin-derived antimicrobial peptide, LL-37, not only possesses broad spectrum antimicrobial activities but is also able to bind and neutralize …
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The interaction of antimicrobial peptides with lipopolysaccharide aggregates and model membranes.
… aggregate structures. The amphiphilic cationic antimicrobial peptides (CAPs) LL37 and LFb possess putative anti-endotoxic activities and were therefore studied using small-angle neutron scattering (SANS) and cryo transmission electron microscopy (cryo-TEM) to assess any modication induced to the …
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Biosynthesis of the Polycyclic Antimicrobial Peptides Lacticin 481, Haloduracin, and Cinnamycin
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2009.
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The identification and characterisation of antimicrobial peptides from snake and scorpion venom.
The need for new antimicrobial agents is becoming one of the most urgent requirements in modem medicine. In the search for new antimicrobial drugs, in recent years, a large amount of research has been undertaken to both identify antimicrobial peptides (AMPs) and elucidate their mechanism of action. …
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Organization of the Streptococcal ExPortal and its Interaction with Cationic Antimicrobial Peptides
… I investigated the interaction of cationic antimicrobial peptides with the streptococcal ExPortal to provide insights into how this secretory organelle is organized and how it may be targeted by this mechanism of innate immunity.</p><p>Cationinc antimicrobial peptides: CAPs) targeted the …
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Eluding Antibiotic Resistance: Capitalizing On Antimicrobial Peptides Interaction With The Lipid Bilayer
… those against Gram-negative bacteria.</p> <p>Antimicrobial peptides (AMPs) have been proposed as an alternative to antibiotics due to their selective activity against microbes and minor ability to induce resistance. For example, the Food and Drug Administration approved Daptomycin (DAP) in …
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DE NOVO DESIGN OF ANTIMICROBIAL PEPTIDES FOR APPLICATION AS ANTI-INFECTIVE AGENTS
Antimicrobial peptides (AMPs) have gathered considerable interest as a new source of antibiotics to tackle the escalating threat of antimicrobial resistance. Adopting a de novo approach enables the rational design of short synthetic AMPs, whilst mitigating concerns of resistance development to …
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Antimicrobial Peptides Activity and Efficacy Prediction by Stochastic Models and Machine Learning Methods
The development of new antimicrobial drugs is becoming more urgent than ever due to the rapid emergence of antibiotic resistance and limitations in bacteria targets. A promising alternative that received considerable scientific attention is antimicrobial peptides (AMPs), also known as host defense …
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Structural and mechanistic studies on antimicrobial peptides that target multi-drug resistant bacteria
Antimicrobial resistance is a growing threat that will have profound effects on global health and the economy. In order to avoid a worst-case scenario, there is a need to develop structurally distinct classes of antibiotics. Herein, the synthesis of cyclic lipopeptides based on the tridecaptins is …
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