Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Antimicrobial peptide (AMP)"”.
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The functional evaluation of a bioactive peptide, QUB-1998, discovered from the skin secretion of the frog, Pelophylax nigromaculata
… alternatives. Through decades of investment, peptides have been proven to be one potential group of biologics that may contribute to the development of new antibacterial drugs, as they combine the advantages of both small molecule medicines and therapeutic proteins.<br/>Through molecular …
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The discovery of a novel dermaseptin identified from the defensive skin secretion of the South American frog, Phyllomedusa sauvagii
… antibiotics. Through decades of investment, peptides have been proven to be one potential group of biologics that may contribute to the development of new antibiotics as they combine the advantages of both small molecule medicines and therapeutic proteins. <br/>Through molecular cloning, the …
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Novel approaches to investigate behaviors of bacteria by atomic force microscopy and circulating tumor cells through microfluidics
… possible two-phase response of bacteria to an antimicrobial peptide (AmP) was discovered by high-speed AFM, and very large clusters of circulating tumor cells (CTCs) with platelets were captured on the microfluidic device - albeit the mechanism by which this happens remains to be determined. …
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QUB-1475: A novel bioactive peptide from the skin secretion of frog Hylarana Guentheri
As antimicrobial resistance has become a threat towards human health for decades, the demand for the development of an alternative, broad-spectrum antimicrobial agent has turned into increasingly essential. As a consequence, the emergence of the antimicrobial peptide (AMP) derived from the skin …
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Assessing bioactivity of peptide QUB3203 from the skin secretion of the Edible frog Pelophylax kl. esculentus
Amphibian skin gradually formed a series of protective mechanisms in the long-term natural selection process in order to resist the effects of harmful environmental factors. The skin secretion contains a large number of active peptides, which can help the amphibian defence system to kill …
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A novel bioactive peptide QUB-2022 from the skin secretion of Phyllomedusa bicolor
The antimicrobial peptide (AMP) is a type of small molecular peptides that are produced by the body against infection. They are commonly considered as a fundamental component of innate immunity and have been extensively discovered in the insects and other non-vertebrate organisms. Amphibian skin …
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Evolution-Inspired Design of Bacterial Biosensors
… first portion of this work, we identify 13 novel antimicrobial peptide (AMP)-activators of the S. Typhimurium PhoPQ two component system (TCS). We characterize the activation profiles of a subset of these AMPs in S. Typhimurium and E. coli using a variety of PhoPQ responsive promoters. We show …
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Novel innate immune functions of saliva
… cavity. Salivary lipids were found to improve antimicrobial peptide (AMP) synthesis and promote clearance of intracellular bacteria in keratinocytes. We also observed how saliva modulates the functions of the prime guardian leucocyte, the neutrophil. Saliva triggers a response via salival …
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Host Defence Peptides (HDPs): investigating the structure-to-function relationship through bio-physical techniques
… antibiotics were isolated while few new antimicrobial drugs were developed. The urgent need for novel efficient antibiotics led a great attention on cationic host defense peptides (HDP) since their discovery in 1980s. The role of these molecules in the defense of organism against …
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Molecular characterization and in vitro functional analysis of putative immunoprotective molecules in the soft tick, Ornithodoros savignyi
… project is on stimulus-induced immunoreactive peptides known as antimicrobial peptides. In chapter 2, an attempt was made to identify a homolog of the anti Gram-positive and bacteriostatic peptide microplusin, in the salivary glands of the argasid tick Ornithodoros savignyi. It was reported …