Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 129 for “"Antimicrobial peptide"”.
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Biosynthesis of the antimicrobial peptide epilancin 15X
Lantibiotics are polycyclic antimicrobial peptides that are ribosomally synthesized and posttranslationally modified to their biologically active forms. The recently discovered lantibiotic epilancin 15X produced by Staphylococcus epidermidis 15X154 is active against several pathogenic bacteria, …
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Specificity of Interaction of Antimicrobial Peptide with Cell Membrane
<p>Antimicrobial resistance (AMR) is an increasing global health threat due to its rising incidence worldwide. Resistant microbial infections have become difficult to treat and pose serious risks to patients. In 2019, AMR was responsible for approximately 1.27 million deaths globally, with numbers …
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Regulation of virulence and antimicrobial peptide resistance in Pseudomonas aeruginosa
… in response to sub-inhibitory concentrations of antimicrobial peptides. Compared to wild-type and the complemented mutant, a P. aeruginosa PAO1 psrA
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Explainable Machine Learning Prediction of Antimicrobial Peptide Targeting Streptococcus mutans
… explainable machine learning pipeline to design antimicrobial peptides targeting S. mutans in responsiveness to the acidic conditions of the cariogenic microenvironments. Our explainable ML pipeline approach transforms the targeted peptide design into a data-driven methodology and bridges the …
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Gene expression control and antimicrobial peptide production by haute couture bacteria
… is a new approach to producing and delivering antimicrobial molecules. The first project is a set of synthetic transcription activators called prokaryotic- TetOn and prokaryotic-TetOff, that upregulate gene expression in response to anhydrotetracycline. The molecular geometries of the …
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Regulation of Antimicrobial Peptide Genes in the Tobacco Hornworm Manduca sexta
… humoral responses mainly include synthesis of antimicrobial peptides (AMPs) and activation of the prophenoloxidase (PPO) system. Expression of AMPs is regulated by two signaling pathways, the Toll-Spätzle (Spz) and immune deficiency (IMD) pathways, in Drosophila melanogaster. My research has …
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Identification of a potential antimicrobial peptide derived from Haliotis midae haemocyanin
… haemocyanin’s potential as a broad spectrum antimicrobial peptide in many arthropod species. There has been only one study conducted in molluscs, which utilised synthetic peptides derived from a haemocyanin consensus sequence. In most organisms the haemocyanin protein is comprised of a string …
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Synthesis of an isotopically labelled analog of the antimicrobial peptide ll-37
… cathelin-associated broad spectrum antibiotic peptide of human neutrophils. Its mechanism of action is by disruption of the bacterial cell membrane structure. LL-21 is a simplified form of the peptide that contains only the core portion of LL-37, which retains antimicrobial activity and is …
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Visualizing the attack of bacteria by the antimicrobial peptide human defensin 5
… various organisms, including humans, produce antimicrobial peptides. Human defensin 5 (HD5) is a 32-aa cysteine-rich peptide produced primarily in the small intestine that exhibits broad-spectrum activity against various bacteria, fungi and viruses. In this thesis, in order to study and …
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In vivo display: a selection and its derivatives for antimicrobial peptide lead identification
… new approaches for the isolation of new antimicrobials with novel inhibitory mechanisms, bypassing the development of rapid resistance by modification of pre-existing resistance mechanisms. In response, we have developed a series of systems for the rapid isolation and identification of …
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NGC-HLB, a novel antimicrobial peptide from the skin secretion of Hylarana latouchii
Antimicrobial peptides from amphibian skin secretions are considered to play a significant role in the host defence mechanisms against bacterial infection. In this study, the identification and antimicrobial activity of a novel peptide named NGC-HLB (GLLSGILGAGKKIVCGLSGLC), is described. The …
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Midaesin - a histone H2A antimicrobial peptide from the South African abalone, Haliotis midae
… farmed in the Western Cape. Histone H2A-derived peptides investigated from various organisms have been shown to act as antimicrobial peptides (AMPs) against a range of microbes. Therefore, the aim of the study was to determine whether the H. midae histone H2A acts as an AMP and thus plays a role …
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Synthesis and solid state F-NMR studies on fluorine-labeled antimicrobial peptide RK-21
<p>Antimicrobial peptides act against bacteria by binding non-specifically and disrupting their outer membrane. LL-37 is the only member of the cathelicidin group of antimicrobial peptides present in humans and shows a broad range of antimicrobial activity. RK-21 is a fragment of human …
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Identification and bio-evaluation of an antimicrobial peptide from the skin secretion of Phyllomedusa tarsius
Antimicrobial peptides (AMPs), as a large classification of biologically active peptides, showed a broad-spectrum efficacy against various microorganisms. Although the antibacterial activity of these peptides already has been proven, studies have shown that antibacterial peptides can also play …
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Regulation of Antimicrobial Peptide Genes in Insects by the Toll Pathway and NF-kB Transcription Factors
… on the other hand include production of antimicrobial peptides (AMPs) by fat body, which is equivalent to mammalian liver, prophenoloxidase, lectins and compliment-like factors. Chapter 1 talks about the important features of insect innate immunity. Chapter 2 discusses the role of the …
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The membrane-active antimicrobial peptide from frog skin and scorpion venom: from mechanistic insight to design
This thesis examines a range of bioactive peptides from the frog skin secretions and scorpion venoms. In chapter 3, studies focused on a novel brevinin-1 type peptide, brevinin-1GHd, found in frog Hylarana guentheri, skin secretion. Functional screening revealed that brevinin-1GHd exhibited potent …
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Investigating the Role of the Antimicrobial Peptide TTO-53 in the Disruption of Pseudomonas aeruginosa Biofilm
… with and influence the rate of transport of antimicrobial agents. Previous research using a synthetic antimicrobial peptide made of unnatural amino acids named TTO-53 has shown its ability to disrupt pre-established P. aeruginosa biofilm. The goal of this study is to investigate how this …
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The expression and regulation on antimicrobial peptide genes in insects: studies in the tobacco hornworm manduca sexta
… humoral responses is the induced production of antimicrobial peptides (AMPs). In D. melanogaster, bacterial peptidoglycan (PG) and fungal beta-1,3-glucan can induce AMP production by activating the Toll and the IMD (immune deficiency) pathway. Chapter 1 reviews the key features of insect innate …
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Analysis of a novel antimicrobial peptide QUB-1746 from the skin secretion of the frog, Kassina senegalensis
… such as biogenic amines, steroids, alkaloids, peptides and proteins. In this thesis, the full-length cDNA sequence of a novel antimicrobial peptide, named QUB-1746, was cloned from a Kassina senegalensis skin secretion derived cDNA library through ‘shotgun’ cloning. The mature peptide was …
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Antibacterial activity and mode of action of the antimicrobial peptide CPF-MW1 against Escherichia coli ATCC 700928
Rapidly emerging antimicrobial resistance and subsequent multi-drug resistance are major global health threats, with the available antimicrobials for treatment being limited. The development of new antimicrobials against Gram-negative bacterial infections is especially challenging due to the …
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