Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 332 for “"Antimicrobial Resistance"”.
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Pinnipeds as sentinels of antimicrobial resistance: mapping antimicrobial resistance genes in the waters of the United Kingdom
Antimicrobial resistance (AMR) is a continual and growing threat to human and animal health. There is a lack of information about environmental reservoirs of AMR, many of which feed into the marine habitat. Pinnipeds are often used as sentinels of ocean health because they are long lived, apex …
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Antimicrobial resistance gene monitoring in aquatic environments
… of an environmental framework for monitoring antimicrobial resistance gene (ARG) dissemination in the aquatic environment. The work opens with a review of the relevant literature and outlines the importance of an environmental framework for monitoring ARG dissemination as part of antimicrobial …
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Role of Bacterial Lipocalin Proteins in Antimicrobial Resistance
… providing a global extracellular mechanism of antimicrobial resistance. In this thesis, I report that watersoluble<br/>and liposoluble forms of vitamin E inhibit antibiotic binding by BcnA.<br/>In vitro, both vitamin E forms bind strongly to BcnA and contribute to reduce the MICs of …
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Balancing farm antimicrobial resistance research and data privacy
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2026-12-01
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Shotgun metagenomic analysis of antimicrobial resistance in wastewater
Antimicrobial resistance (AMR) threatens our modern standard of living with the potential return to a pre-antibiotic condition where deadly infections are no longer treatable. Wastewater treatment plants (WWTPs) are vital components in water sanitation infrastructure and are now also being …
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Molecular Mechanisms of Antimicrobial Resistance In Multi-Drug Resistant Enterococci
<p>Antibiotic resistance is a major global public health threat. Enterococci are recalcitrant, nosocomial pathogens that can be intrinsically resistant to valuable antibiotics, like beta-lactams, or evolve resistance to all existing antimicrobials. The LiaFSR system regulates resistance to cell …
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Investigating antimicrobial resistance mechanisms in Neisseria gonorrhoeae using peptide probes
The continuing evolution of antibiotic resistance strains of Neisseria gonorrhoeae coupled with the paucity of new antimicrobial agents makes the treatment of gonococcal infections challenging. A major cause of resistance is the expression of a multidrug efflux pump termed MtrCDE, which exports a …
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MODELING AND MINING ANTIMICROBIAL RESISTANCE IN HUMAN AND ANIMAL POPULATIONS
Antimicrobial resistant bacteria existed before the medical use of antimicrobials but increasing antimicrobial use has escalated the development and spread of resistant bacteria in human and animal populations. Resistant bacteria and resistance genes spread between individuals through direct and …
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Using wildlife to biomonitor for antimicrobial resistance in the Scottish environment
Antimicrobial resistance (AMR) is a threat to global health. Surveillance of AMR<br/>bacteria in wildlife host is key to understanding and tracking their spread<br/>throughout our environment. We established baseline data on the prevalence of<br/>AMR E. coli in Scottish wild deer, utilising faecal …
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Characterization of antimicrobial resistance among canine urinary isolates in Western Canada
… common causes of canine UTIs. The emergence of resistance to first line antimicrobials in these pathogens has posed challenges for veterinarians to treat their patients. Surveillance to detect the emergence of antimicrobial resistance (AMR) in companion animal pathogens is lacking in Western …
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Evolutionary Trade-offs Between Antimicrobial Resistance and Virulence in Pseudomonas aeruginosa
Antimicrobial resistance (AMR) threatens antibiotic efficacy, yet its evolutionary consequences for pathogen virulence and growth remain poorly resolved. This thesis addresses this gap using Pseudomonas aeruginosa, a multidrug-resistant pathogen capable of both acute toxin-mediated and chronic …
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Understanding the Genetics and Evolution of Antimicrobial Resistance in Escherichia Coli
Antimicrobial resistance (AMR) has emerged as a global public health challenge. The central goals of my PhD research are to better understand AMR evolution, with the long-term goal of developing novel strategies to mitigate the problem of AMR. This involves gaining comprehensive insights into the …
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Evaluation of Macrolide-Lincosamide-Streptogramin B Antimicrobial Resistance at Swine Farms
Antimicrobial use in animal agriculture contributes to increased levels of antimicrobial resistance in the environment. To better evaluate this concern, the levels of macrolide-lincosamide-streptogramin B (MLSB) antimicrobial resistance at swine farms were quantified. A variation of fluorescence in …
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Evolution and Regulation of Virulence and Antimicrobial Resistance in Pseudomonas aeruginosa
… metabolic versatility, its propensity to acquire antimicrobial resistance (AMR) and the ability to produce numerous virulence factors. However, the expression of virulence factors is costly for the cell and, therefore, tightly regulated via quorum sensing (QS). P. aeruginosa has three main …
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Computational studies on polyunsaturated fatty acid uptake and its effects on antimicrobial resistance
… This uptake has been linked to increased antimicrobial resistance, motility, biofilm formation, and virulence phenotypes. This research was a collaboration between Dr. David Giles and Dr. Bradley Harris to computationally investigate the uptake mechanism for the uptake of long chain fatty …
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Antimicrobial Resistance Mediated By Synthesis of Richmond and Sykes Type I Beta-Lactamase
… current methodology for detection of this resistance and delineate situations wherein these problems are expected to arise. Prevalence of inducible beta-lactamases occurring in a hospital setting was determined along with frequency of mutation to a stably derepressed state. Interactions …
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Assessment of Antimicrobial Resistance in Pathogens Responsible for Causing Bovine Mastitis in Kentucky
… herds, and to assess the presence of antibiotic resistance in these pathogens. In this study, 308 milk samples were obtained from cow's selected based on their recent somatic cell count. Samples positive for growth were identified using the gram stain and various biochemical tests. After …
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Antimicrobial resistance patterns of foodborne bacterial isolates from HIV/AIDS patients in Lusaka, Zambia.
Antimicrobial resistance is a major global public health concern and a food safety issue. When pathogens become resistant to antimicrobial agents they can pose a greater human health risk as a result of potential treatment failure, loss of treatment options and increased likelihood of severity of …
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