Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Antimetabolites"”.
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Existence of Inhibitor of Apoptosis in Tumor Exosomes
… pancreatic cancer is chemotherapy where only the antimetabolites gemcitabine (Gem) and 5-fluorouracil (5FU) are used clinically. However, resistance to these antimetabolites remains a problem highlighting the need to discover and develop new antimetabolites that will improve a patient’s overall …
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Endocrine Effects of Cancer Chemotherapy
… drug classes—such as alkylating agents, antimetabolites, antitumor antibiotics, targeted therapies, and immune checkpoint inhibitors—affect the endocrine system. It examines chemotherapy-induced dysfunctions in key endocrine glands, including the hypothalamus-pituitary axis, thyroid, …
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Studies in the synthesis of pyrimidines, pyrazoles, and pyrazolo pyrimidines. New syntheses of 1, 3 and 5 substituted pyrazolo [3, 4-d] pyrimidines, including glycosides related to naturally occurring pyrimidines, imidazoles, purines and their nucleoside derivatives.
… or nucleotide derivatives, are valuable antimetabolites in that they may block normal RNA or DNA polymerisation, or may be incorporated into nucleic acids to form fraudulent, but not necessarily defective, polymers. Modification of natural ring systems, with a view to promoting …
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Antibiotic Drug Discovery Targeting Bacterial Metabolism
… optimized to measure the biological activity of antimetabolites, which is often masked by nutrients present in standard testing media. This screen yielded an inhibitor of cysteine synthase A in Escherichia coli, which was characterized in chapter four. Multiple experimental approaches yielded …
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Transient Metabolic Alterations Induced by Chemotherapeutics in Cancer Persisters
… predominantly active in cultures treated with antimetabolites that act as a nucleoside analog for deoxycytidine. Overall, these results lead us to believe that cJUN, which is at the crossroads for both cell survival and apoptotic pathways, plays a significant role in persister physiology.
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INVESTIGATION OF ANTIBIOFILM AND ANTIVIRULENCE ACTIVITY OF 5-FLUOROCYTOSINE IN ESCHERICHIA COLI
… are considered as a promising strategy. Several antimetabolites and nucleobase/nucleoside analogues, such as 5-fluorocytosine and 5-fluorouracil, have been shown to possess antivirulence activity in Gram negative bacteria like Pseudomonas aeruginosa and Escherichia coli. In my PhD work, based on …