Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"Antimalarial activity"”.
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Antimalarial activity and pharmacokinetic properties of new chemical entities
Includes abstract. Includes bibliographical references.
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Evaluation of antihistamines for in vitro antimalarial activity against Plasmodium falciparum
The declining efficacy of antimalarial drugs against resistant Plasmodium falciparum strains in several endemic regions has amplified the world’s burden of neglected diseases. This has highlighted the need for alternate strategies for chemotherapy and chemoprophylaxis. Since malaria is prevalent …
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Bioassay-guided fractionation of Artemisia afra for in vitro antimalarial activity against Plasmodium falciparum
… much interest in natural plant products for new antimalarials with novel modes of action against Plasmodium. Artemisinin or Qinghaosu is one such antimalarial isolated from a Chinese herb, Anemisia annua (Asteraceae) and it is currently undergoing phase I and II clinical trials. The Southern …
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Synthesis and investigation of benzimidazole and carbazole ß-haematin inhibiting scaffolds with antimalarial activity
… late 1960s when resistance began to emerge. This antimalarial targets haemozoin formation which causes a cytotoxic accumulation of free haem in the malaria parasite leading to parasite death. This is still one of the most promising pathways for treatment of the most prevalent species of malaria …
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Antimalarial activity and cytotoxicity of some South African medicinal plants and their active constituents
Includes bibliographical references (leaves 150-187).
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Phytochemical, Chemopreventive and Antimalarial Activity Evaluation of Five Selected Medicinal Plants from the Cameroonian Flora
Screening of ethnomedicinal plants for antimalarial and chemopreventive activities among plants used in Cameroonian folklore medicine to treat fevers, malaria and tumour was conducted on Croton oligandrus (Euphorbiaceae), Justicia hypocrateriformis (Acanthanceae), Pseudospondias microcarpa …
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Antimalarial activity of hypoxis colchicifolia, bak, mimusops caffra, E. Mey. ex A.DC and mimusops obtusifolia, lam from South Africa
… were screened for antioxidant, antipyretic, and antimalarial activity. The antioxidant activity of the methanol extracts was determined by measuring the decrease in the colour of an oxidative system in the presence and absence of the extract. The various antioxidant activities tested include free …
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The antimalarial activity of Dicoma anomala and the chloroquine resistance reversing effects of Sclerocarya birrea on Plasmodium falciparum in vitro
Two plants, Dicoma anomala [Sond.]; a member of the Asteraceae and Sclerocarya birrea [(A. Rich) Hoechst. subspecies caffra (Sond.) Kokwaro], a member of the Anarcadiaceae families, are used widely in Africa for a variety of traditional treatments. In this thesis it has been shown that these plants …
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Isolation and Synthesis of Bioactive Compounds from Plants
… were investigated for their antiproliferative activity against the A2780 cell line, three plant extracts were investigated for their antimalarial activity against Plasmodium falciparum, and three plant extracts were investigated for their anti-inflammatory activity (PPAR-y inhibition). …
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Investigating calcium channel blockers as antimalarials
The rise in resistance to current antimalarial drugs has led researchers to consider drug repositioning as a quicker alternative for drug development and discovery. Preliminary drug repositioning screens carried out at the University of Salford identified calcium channel blockers (CCBs) as …
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Antiprotozoal quinolines containing electrophilic moieties
… the quinoline moiety have been the mainstay of antimalarial chemotherapy. However, the emergence of resistant strains of Plasmodium falciparum, the causative agent of malaria, has compromised the efficacy of these antimalarial quinolines. Therefore the development of new efficient drugs is of …
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I. Isolation and Characterization of Bioactive Compounds From Suriname and Madagascar flora. II. A Synthetic Approach to Lucilactaene
… Madagascar were bioassayed for cytotoxicity and antimalarial activity. Six cytotoxic extracts and one potential antimalarial were selected for fractionation, and yielded a number of bioactive compounds which were characterized by spectroscopy methods. Craspidospermum verticillatum (Apocynaceae) …
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The therapeutic effectiveness of some local Nigerian plants used in the treatment of malaria
… and standardization of herbal drugs with potent antimalarial activity.
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Discovery, Isolation, and Identification of Antimalarials from Fungal Endophytes
… bacterial, fungal and protozoal pathogens. Once antimalarial activity was discovered and confirmed, we sought to isolate and identify the active constituent(s) of our extracts. Bioassay-guided fractionation techniques were used to isolate our active compound, the structure of which was elucidated …
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Curcumin-related hybrid compounds as potential antimalarial agents : design, synthesis, mechanistic investigations, biological evaluation and pharmacokinetic studies
… resistance Of the parasite to most known antimalarial drugs. This suggests that the development of new, highly efficadous drugs and/or treatment regimens for the management of malaria remains a key priority. This study applied molecular hybridization as a strategy in the development of …
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Investigating ethnopharmacology-based natural product leads for antimalarial drug discovery
… of a range of traditional “fever cures” for antimalarial efficacy. The main objective of this study is to identify a suitable antimalarial plant candidate towards the development of a phytopharmaceutical drug (a plant-based medicinal mixture/compound used in preventive or therapeutic …
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Design and synthesis of novel P. fulciparum GDH inhibitors for use as potential antimalarial agents
… This has led to a new impetus to look for new antimalarial drugs that have different modes of action to the ones that are currently available. This thesis contains the following areas of research: 1) The design and synthesis of various compounds of the classes substituted benzyl-αhydroxy …
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Antimalarial Evaluation of Quinoline-triazoleMn(I) and Re(I) PhotoCORMs
… calls for the urgent development of new antimalarial chemotherapeutic drugs. It is of great importance to develop compounds that target resistant strains of malaria. Chloroquine is one of the most significantly studied antimalarials to date and its derivatives have been mainstays in …
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SYNTHESIS AND EVALUATION OF FOSMIDOMYCIN ANALOGUES AS ANTIMALARIAL AGENTS
… the design and development of new agents with antimalarial activity. The enzyme 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR), which is involved in the DOXP pathway for isoprenoid synthesis, was chosen as drug target. This non-mevalonate pathway is not operating in humans and inhibitors …
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