Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 64 for “"Antimalarial Drug"”.
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Accelerating antimalarial drug discovery through repositioning
… measures have been hampered by the emergence of drug resistance to most antimalarial therapies. Early signs of drug resistance to the current frontline option, the artemisinins, make it imperative that novel drug candidates are discovered. One possible short-term solution is drug repositioning, …
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Changing Antimalarial Drug Sensitivities in Uganda
… to lumefantrine. To gain insight into current drug sensitivity patterns, <em>ex vivo</em> sensitivities were assessed and genotypes previously associated with altered drug sensitivity were characterized for 58 isolates collected in Tororo, Uganda from subjects presenting in 2016 with malaria …
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A simulation model of antimalarial drug resistance
… does not stop as the change in response to antimalarial drug treatment requires the development of new drugs and innovation in the use of old drugs. This thesis focused on building a model of the spread of resistance to Sulfadoxine/Pyrimethamine (SP) in a setting where both SP and SP in …
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Exploring Protoheme IX Farnesyltransferase as an Antimalarial Drug Target
The search for novel antimalarials continues due to the need to combat the rapidly increasing prevalence of multidrug resistant Plasmodium species parasites that cause malaria. Recent advances in technology to genetically modify malarial parasites and methods for high throughput screening of …
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Investigating ethnopharmacology-based natural product leads for antimalarial drug discovery
… of a range of traditional “fever cures” for antimalarial efficacy. The main objective of this study is to identify a suitable antimalarial plant candidate towards the development of a phytopharmaceutical drug (a plant-based medicinal mixture/compound used in preventive or therapeutic …
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Antimalarial Drug Resistance: Mechanisms of Emergence in Low-Transmission Settings
Antimalarial drug resistance is a major factor affecting global malaria control, causing treatment failure and significant morbidity and mortality. Resistance has historically emerged in low-transmission areas before spreading to high-transmission areas, and there is consequently widespread …
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Totarol as privileged natural product scaffold for antimalarial drug discovery
… A continuous effort to find alternative antimalarials to this drug has led to the discovery of other effective antimalarials of different types, such as aminoquinolines, artemisinins and nucleic acid inhibitors. However, the emergence of multi-drug resistant strains of the malaria …
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Supramolecular derivatisation of new anti-tubercular and antimalarial drug leads
The UCT Drug Discovery and Design Centre, H3D, provided anti-tubercular and antimalarial drug leads that display potent in vitro and in vivo activity, but with unfavourable physicochemical properties. The primary objective of this study was to prepare supramolecular derivatives of the drug leads in …
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Antimalarial drug rescue through safety improvement: design, synthesis and evaluation of amaodiaquine analogues
… strains resistant to all known clinically used antimalarials. This underscores the need for the development of new drugs that retain efficacy against the resistant parasites. In this study, analogue-based drug design was employed as a form of drug ‘rescue’ in the development of novel potential …
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Single Cell Study of Malaria and Antimalarial Drug Impacts on Platelets and Mast Cells
… were studied for their response to two common antimalarial drugs using the same single cell technique. Chapter 1 gives an overview of single cell analysis techniques (optical,electrochemical, mass spectrometric, and microfluidic methods) and their recent progress in biological applications. …
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Impactful maps and associated visualisations on antimalarial drug resistance for malaria programmes and policymakers
The spread of antimalarial drug resistance threatens global, regional and national malaria elimination efforts. Despite being preventable and treatable, malaria still claims over half a million lives globally, with over 95% of malaria cases and deaths occurring in Africa. Antimalarial drug …
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Development of Artemisia annua L. as a crop for production of the antimalarial drug artemisinin
… for the latest generation of anti-malarial drugs. In many cases of severe or drug-resistant malaria, the artemisinins are the only effective means of treatment for this common and life-threatening parasitic infection. However, the current supply of artemisinin is unstable, and is predicted …
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An in vitro chemogenomic screening system to identify the molecular targets of antimalarial drug candidates
The efficacy of existing antimalarials is threatened by parasite resistance, driving the need for a well-stocked pipeline of potential replacement therapies. A global effort to carry out phenotypic screening in live parasite assays has identified many promising hit compounds, but elucidating the …
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Estimating antimalarial drug activity in vivo: an interdisciplinary approach combing novel experimental data with mathematical modelling
… However, it is urgent to develop better antimalarial because artemisinin-resistant parasites are spreading, and the international efforts to eradicate malaria have stalled. There are currently 46 drugs in development by the Medicines for Malaria Venture at different phases of the drug …
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Development of novel chemical biology tools to probe malaria parasite physiology and aid in antimalarial drug discovery
… remains a major burden to global public health. Antimalarial drugs are a mainstay in efforts to control and eventually eradicate this disease. However, increasing drug resistance threatens to reverse recent gains in malaria control, making the discovery of new antimalarials critical. Antimalarial …
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The change in malaria treatment policy in Uganda : extent of adherence to antimalarial drug policy in Rakai and Kampala Districts
Changes in Antimalarial Drug Policies are intended to improve case management and reduce both social and financial burden associated with malaria. To achieve this providers have to translate the policy into practice since they have the privilege of being the primary contact to those affected by …
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Engineering human hepatic tissue for modeling liver-stage malaria
… is an attractive target for the development of antimalarial drugs and vaccines, as it provides an opportunity to interrupt the life cycle of the parasite at a critical early stage. However, targeting the liver stage has been difficult due to a lack of human liver models that robustly …
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Discriminative Stimulus Effects of Putative Antipsychotic Drugs
… stimulus properties of antipsychotic drugs, by establishing the typical antipsychotic drug chlorpromazine, and the atypical antipsychotic drug clozapine as discriminative stimulus in two different groups of rats. The rats trained to discriminate chlorpromazine from vehicle failed to do …
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Development of harmonised approaches for detecting and recording participant-reported anti-malarial drug safety data: The Delphi process
… research participants is integral for evaluating drug safety. However, using different methods to question participants yields inconsistent results, compromising the interpretation, comparison and pooling of data across studies. This is particularly important given the widespread use of …
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