Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 240 for “"Antimalarial"”.
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Antimalarial and cysteine protease inhibitor pharmacophores as scaffolds for new antimalarial agents
… a subunit that is found in a number of antimalarial agents. (ii) Various thiosemicarbozones and semicarbozones were designed and synthesized as potential mechanism-based inhibiotrs of parasitic cysteine proteases. (iii) Multicomponenet reactions offer the advantage of introducing …
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Accelerating antimalarial drug discovery through repositioning
… by the emergence of drug resistance to most antimalarial therapies. Early signs of drug resistance to the current frontline option, the artemisinins, make it imperative that novel drug candidates are discovered. One possible short-term solution is drug repositioning, via screening existing …
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Synthesis of the Antimalarial Flindersial Alkaloids
The concept of mimicking nature to synthesize natural compounds has been successfully demonstrated in the synthesis of all the anti-malarial Flindersia alkaloids. Previous work on the biosynthesis of the related natural products borreverine and isoborreverine inspired us to synthesize racemic …
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Changing Antimalarial Drug Sensitivities in Uganda
… with resistance to artemisinins or piperaquine. Antimalarial drug sensitivities are changing in Uganda, but novel genotypes associated with DP treatment failure in Asia are not prevalent.</p>
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A simulation model of antimalarial drug resistance
… does not stop as the change in response to antimalarial drug treatment requires the development of new drugs and innovation in the use of old drugs. This thesis focused on building a model of the spread of resistance to Sulfadoxine/Pyrimethamine (SP) in a setting where both SP and SP in …
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Screening of actinobacteria for novel antimalarial compounds
The success of our first-line antimalarial treatments is threatened by increased drug resistance in Plasmodium parasites. This makes the development of novel drugs critical to combat malaria. Historically, natural products have been an excellent source of novel antimalarial compounds and thus are …
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Synthesis of 1,4 Dihydropyridines as potential antimalarial chemotype
… stage that is believed to be a target for most antimalarial drugs. It is in this stage that host haemoglobin is degraded to provide nutrients for the survival of the parasite. However, a pathway (known as the haem detoxification pathway) that gives rise to the unique, microcrystalline …
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The design and synthesis of novel potential antimalarial compounds
The work contained in this thesis is split into two sections. Each section covers a different biological pathway, its current importance as a potential drug target, and the syntheses towards a selection of natural products and analogues relevant to the pathway. In Section A, the novel approach …
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SYNTHESIS AND EVALUATION OF FOSMIDOMYCIN ANALOGUES AS ANTIMALARIAL AGENTS
… the design and development of new agents with antimalarial activity. The enzyme 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR), which is involved in the DOXP pathway for isoprenoid synthesis, was chosen as drug target. This non-mevalonate pathway is not operating in humans and inhibitors …
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Structure activity and structure property relationships of antimalarial imidazopyridazines
… falciparum. However, the majority of the antimalarial imidazopyridazine compounds evaluated to date have solubility and off-target human ether-a-go-go-related gene (hERG) potassium ion channel liabilities. Towards improving solubility and de-risking the hERG liability, a series of …
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Novel Antimalarial and Antitubercular Agents Based on Natural Products
… that is, most of the clinically used drugs in antimalarial and antitubercular chemotherapy are of natural product-origin. In this project we therefore focussed on the design, synthesis, characterization and biological evaluation of novel antimalarial and antitubercular agents obtained by …
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Phytochemical studies on traditional medicinal plants with antimalarial activities
The active antimalarial principles of three traditional medicinal plants, Passerina obtusifolia (Thymelaeaceae), Tetradenia riparia (Labiatea) and Xerophyta retinervis (V elloziaceae) were investigated by employing bioassay guided fractionation. Two novel compounds and five known constituents were …
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Antimalarial activity and pharmacokinetic properties of new chemical entities
Includes abstract. Includes bibliographical references.
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Exploring Protoheme IX Farnesyltransferase as an Antimalarial Drug Target
The search for novel antimalarials continues due to the need to combat the rapidly increasing prevalence of multidrug resistant Plasmodium species parasites that cause malaria. Recent advances in technology to genetically modify malarial parasites and methods for high throughput screening of …
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Antimalarial Afterlives: Medicine for a Planetary Age from Madagascar
… long cultivated as cash crops for exported antimalarial drug ingredients. But as artemisia was “repositioned” from a global antimalarial drug to a domestic Covid-19 treatment, I argue that social sciences of medicine must expand a “biographical approach” to pharmaceuticals with attention to …
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Searching for Anticancer Agents and Antimalarial Agents from Madagascar
… human ovarian cancer line, and one extract with antimalarial activities was studied, which led to the isolation of five new natural products with antimalarial activities against the Dd2 and HB3 malarial parasites. The plants and their metabolites are discussed in the following order: one new …
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