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Showing 1 to 5 of 5 for “"Antilipoperoxidant"”.
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Modular synthesis-enabled mechanistic characterization of the potent antilipoperoxidant activity of peridinin
… the evolution of natural products with potent antilipoperoxidant activity in microorganisms that thrive in environments of extreme oxidative stress. Enabled by a modular building-block synthetic platform, the structurally atypical carotenoid peridinin was found to be a potent inhibitor of …
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Total synthesis and study of the antilipoperoxidant peridinin, synthesis of versatile MIDA boronate building blocks, and a general strategy for the synthesis of polyenes
… Utilizing this synthetic material, we probed the antilipoperoxidant activity of peridinin in a chemically defined liposome based system and discovered that peridinin is far more potent than the leading carotenoid gold standard astaxanthin. Detailed mechanistic studies revealed that this superior …
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Synthesis, biological activity and mechanism of atypical carotenoid antilipoperoxidants
… class of polyene containing small molecules with antilipoperoxidant activity. Yet no significant progress has been made towards utilizing carotenoids either as clinically proven treatments or to definitively probe the role of lipid peroxidation in disease pathogenesis. We therefore sought to …
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An iterative cross-coupling based approach to the synthesis of peridinin and progress towards peridinin derivatives
… small molecules with the ability to act as antilipoperoxidants have the potential to serve as powerful pharmaceuticals. Peridinin, an atypical carotenoid found in dinoflagellates responsible for the color of red tide, is especially interesting as a potential antilipoperoxidant because it may …
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Expansion and automation of iterative cross-coupling: total synthesis of synechoxanthin and development of a small molecule synthesizer
Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2014-04-15T20:00:36Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 1 Sisco_Seiko.pdf: 39731093 bytes, checksum: c5a677f96924a2150cc9bc68dfe0cc54 (MD5)