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Showing 1 to 6 of 6 for “"Antigens, Neoplasm"”.
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Development of an αᵥβ₆-Binding Peptide for In Vivo Applications: Modulation of Serum Stability and Biodistribution
Targeted delivery of imaging and therapeutic agents to tumors improves detection, characterization, and treatment of many types of cancers. Peptides are capable of efficient and selective delivery of a variety of cargoes to their target cells and have been in development as targeting ligands for a …
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NK Cell Function and Tumor Resistance in Mice Transgenic for Antibody to NK Inhibitory Receptors
Tumor surveillance has been proposed as a means whereby the immune system monitors and eliminates transformed cells before their growth. Transformed cells that survive the immune response are escape variants selected by nature as they have developed mutations in immune recognition components. To …
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Examining the Regulation and Function of Cancer Testis Antigens
Cancer Testis Antigens (CTAs) are a class of genes whose expression is generally restricted to the testis, but are reactivated in cancer cells. The function and regulation of many CTAs are unknown, however several CTAs have been shown to impact tumor cell fitness and correlate with poor prognosis. …
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Analysis of Meiotic Cancer Testis Antigens and Their Contribution to Tumorigenesis
… required for meiosis. These Cancer Testes Antigens (CTAs) have been found to play critical roles in multiple cellular processes when aberrantly expressed in cancer. Here I found that the CTAs SPO11, GAGE and HORMAD1 play critical roles in cell survival, modulating response to DNA damaging …
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The Cancer Specific Ubiquitin Ligase MAGE-A3/6-TRIM28 Drives Tumorigenesis by Ubiquitination and Proteasomal Degradation of AMPK
The genes MAGE-A3 and MAGE-A6 (MAGE-A3/6) have a unique expression pattern in which they are normally expressed in the adult testis but are aberrantly expressed in cancer. It is known that when expressed in cancer, MAGE-A3/6 is a negative prognostic indicator and cancer cells are dependent on it …
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Existence of Inhibitor of Apoptosis in Tumor Exosomes
<p>Pancreatic cancer is a deadly and aggressive disease. The only option for metastatic pancreatic cancer is chemotherapy where only the antimetabolites gemcitabine (Gem) and 5-fluorouracil (5FU) are used clinically. However, resistance to these antimetabolites remains a problem highlighting the …