Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Antigenic Evolution"”.
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Predicting the Antigenic Evolution of Influenza Viruses with Application to Vaccination Strategy
… mortality and morbidity every year. The evolution of these viruses comprise unique systems for studying natural evolutionary processes in real-time. Host immune systems recognise pathogens based on binding affinities between host antibodies and pathogen antigens. Pathogens with similar …
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Integrative approaches to decipher influenza evolution, antibody responses, and AI-driven specificity prediction
… need to understand immune responses and viral evolution to guide therapeutic and vaccine development. This dissertation integrates high-throughput experimental techniques and artificial intelligence (AI) to address key questions in virus-immunity interactions through three interconnected …
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Prediction and surveillance of antigenic variation in influenza and SARS-CoV-2 viruses
… has long been a primary model organism for antigenically variable pathogens meaning it can escape immunity acquired through prior exposure by accumulating mutations in the key surface proteins targeted by the immune system (hemagglutinin in the case of influenza). As such, the strain …
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Responding to an Evolving Pandemic: Characterisation of Emerging Evolving Viruses and Population Immunity by the Example of SARS-CoV-2
… same time unique opportunities. Following the evolution of a novel human virus, together with the development of population immunity against it, allowed us to test knowledge acquired through decades of influenza virus research on SARS-CoV-2. In this thesis, I will describe how I used …
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Variation in influenza virus neuraminidase activity influences the evolutionary trajectory of hemagglutinin
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2026-05-01
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Improving the analysis of surveillance antigenic data to support seasonal influenza vaccine composition recommendations
… One of the key inputs to this decision is the antigenic phenotype, measured by antibody titres using haemagglutination inhibition and virus neutralisation assays with ferret and human sera. Analyses of these data using antigenic cartography to produce a quantitative visualisation of antigenic …