Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Antigen-specific T cells"”.
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T-cell receptor diversity of various antigen-specific T cells
T cells recognize foreign antigen through a heterodimeric $\alpha\beta$ T-cell receptor (TCR). The TCR ligand is a peptide bound to a membrane-bound protein coded by the major histocompatibility complex (MHC) locus. Like immunoglobulins, the TCR repertoire is diverse because both the $\alpha$ and …
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Studies on the molecular mechanism of T cell triggering and detection and characterization of antigen-specific T cells
… technique for identifying and characterizing specific T cell responses in parallel. The system involves incubating heterogeneous T cell mixtures with artificial antigen-presenting microarrays, which include immobilized cytokine capture antibodies, co-stimulatory molecules, and MHC complexes …
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Factors contributing to T cell persistence in a tolerizing tumor environment
… chemotherapy and immunotherapy. CD8[+] T cells are adaptive immune cells responsible for eradicating tumor cells. However, these T cells can be rendered ineffective through tolerance. Yet in various mouse models and human patients, tolerant T cells persist. The aim of this project is to …
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Investigation of T cell signalling events regulating immunity and tolerance in vivo
… discriminate between pathogenic and self or food antigens is essential not only for the generation of a productive immune response against invasive pathogens, but also for a state of antigen-specific tolerance to be elicited against harmless antigens. A breakdown in such tolerance can result in …
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AUTOANTIGENS IN PARKINSON'S DISEASE
… This thesis examines the role of two autoantigens, α-synuclein and the stress inducible phosphoprotein 1(STIP1) in PD. α-synuclein has been widely implicated in PD pathogenesis while STIP1’s role in PD remains to be determined. Here, we performed a detailed characterization of …
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The Role of the PD-1 Immunoreceptor in Pregnancy
… of the PD-1 receptor in modulating maternal T cells during pregnancy. PD-1 is preferentially expressed on human decidual T cells and B7-H1 inhibits the inflammatory cytokine production of activated decidual T lymphocytes. In addition, possibly through B7-H1:PD-1 interactions, trophoblasts …
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Humanized Chimeric Receptors in the Therapy of Multiple Sclerosis
<p>The role of autoreactive, antigen-specific T-cells in the development of autoimmunity has long been documented. T-cells expressing chimeric receptors are specifically redirected against such cells and have been proven to suppress autoimmune encephalomyelitis, the murine model of multiple …
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Oligosaccharide-mediated targeting of dendritic cells and the development of carbohydrate microarrays
Bone-marrowed derived dendritic cells (DCs) constitute a critical arm of the immune system capable of polarizing the immune response toward active immunity or tolerance. Successful therapeutic modulation of DC function in vivo should create opportunities for more potent, efficacious vaccines and, …
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Generation and analysis of transgenic mice expressing ovalbumin as a neo-self antigen under control of the myelin basic protein promoter
… neuritis (EAN) models have demonstrated that T cells play a major role in these diseases. Which roles CD4 and CD8 T cells specifically have in the initiation, propagation and termination of an autoimmune nervous system disorder remains controversial. To this end two transgenic mice specifically …
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In vivo generation of 'vaccination nodes' using injectable alginate hydrogels for cancer immunotherapy
… the amount of ongoing intensive research, tumor cells have continued to outwit us in the effort to combat and prevent cancer by exerting a number of mechanisms to evade and suppress anti-tumor immune responses. The present work employs strategies to generate a synthetic extranodal immunoplatform …
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Role of Notch Signaling and GATA-3 in Establishing T-lineage Commitment and Survival in Developing Thymocytes
The adaptive immune response, including antigen-specific T cells, is crucial in resolving infections and protecting against tumourigenesis. However, the precise molecular signals needed for the development of these cells are still not clearly defined. The Notch signaling pathway is required to …
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Characterisation of high and low avidity peptide specific CD8+ T cells using immunologic, transcriptomic and proteomic tools
… is the generation of high avidity cytotoxic T cells which can recognise and respond to very low concentration of antigens. This sensitivity of T cells is usually determined by peptide titration ELISpot assays. Even though these assays are generally useful, they are laborious and sample …
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T lymphocyte responses to equid herpesviruses 1 and 4 in horses
… and use of assays to measure equine herpes virus-specific proliferative and cytotoxic T lymphocyte (CTL) responses in the blood of horses. Equine T cell blast cells stimulated from peripheral blood mononuclear cells (PBMC) with pokeweed mitogen were found to perform best as targets for CTL in "Cr …
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Molecular mechanisms and complete antigen formation in allergic contact dermatitis
… in the skin, and processed further into complete antigens. Antigen specific T cells then recognize the resulting antigen. Although the haptens are well known, the chemical reactions of haptens inducing ACD is not well known. Neither are the chemical structures of the complete antigens associated …
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Identification of protective rickettsial antigens for vaccine development
… rickettsiae are attributed to the induction of antigen-specific T cells, particularly CD8+ T cells. Defining specific T-cell antigens and correlates of protective cellular immunity are critical steps towards vaccine development for Rickettsia. However, these are major gaps in this field that are …
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The Host Response to Venezuelan Equine Encephalitis Virus
… factors indicated a role for natural killer cells in pathogenesis. Subsequent loss and gain of function studies in the natural killer cell compartment in C3H mice demonstrated a pathogenic role for this cell type. In TCR KO mice, αβ T-cells appear to be required for clearance of virus, but …
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Roles of γδ T Cells in Influenza Infections and Methods for TCR Expression and Characterization
… infections and the potential methods to engineer antigen-specific T cells for immunotherapy against cancers and infections will be the focus of this dissertation." "Compared to adults, infants suffer higher rates of hospitalization, severe clinical complications, and mortality due to influenza …
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Recording Cellular Interactions in Germinal Centers and Beyond
… are fundamental. For instance, the priming of antigen-specific T cells relies on their selective engagement with antigen-presenting cells (APCs) displaying the T cell's cognate antigen, distinguishing them from a pool of non-specific counterparts. Similarly, the production of antibodies by …
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Low-Frequency Sonophoresis Assisted Cancer Immunotherapy
… (LFS), followed by topical ovalbumin antigen application, results in the induction of a potent CTL response in the absence of any co-administered adjuvants. LFS is a minimally invasive, FDA approved technique for the transdermal delivery of lidocaine. Significant research has been …
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