Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"Antigen recognition"”.
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Antigen Recognition by an Alloreactive T Lymphocyte Clone
… acid substitutions in the center of the alloantigenic peptide. In chapter four, the energy of antigen recognition is mapped using soluble 2C TCR and the alanine-scanning mutagenesis technique. A majority of the binding energy for alloantigen recognition is derived from residues within the CDR …
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Characterization of Antigen Recognition by a T Lymphocyte Clone
… responses that can be elicited by peptide/MHC recognition. We demonstrated that the endogenously derived peptide, dEV8, functioned as both an agonist and an antagonist of T cells derived from 2C TCR transgenic mice. Although the exact mechanism underlying the opposing effects of the same pepMHC …
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Combined experimental and modeling studies reveal new mechanisms in T cell antigen recognition
T cells of the immune system recognize small antigen peptide fragments loaded onto Major Histocompatibility Complex (pMHC) molecules through their T Cell Receptor (TCR). The recognition of antigenic pMHC by the TCR is an extremely sensitive and specific process, discriminating as few as a single …
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Recovery of T cell receptor variable sequences from 3' barcoded single-cell RNA sequencing libraries
… features, including variable sequences of T cell antigen receptors (TCRs) that confer antigen specificity. Incorporation of TCR sequencing into scRNA-seq data could identify cells with shared antigen-recognition, further elucidating dynamics of antigen-specific immune responses in T cells.
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The evolution of the autoantibody response in Graves’ disease
… on the mature heavy chain. Significantly, antigen recognition studies of rFab germline, KSAbl and KSAb2 showed binding to OmpA, OmpC and OmpF of Y. enterocolitica. Our findings raise the possibility that the clonal expansion of B cell populations that acquire autoreactivity in the periphery …
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Lipid-protein interactions of immunoreceptor signaling subunit cytoplasmic domains
… protein-lipid interactions of subunits of key antigen recognition receptors of the immune system are investigated. The proteins studied are the cytoplasmic domains of immunoreceptor signaling subunits that mediate transmembrane signal transduction in response to receptor engagement. The …
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Engineering of next-generation chimeric antigen receptors based on alternative binding domains
Exogenous expression of chimeric antigen receptors (CARs) on T lymphocytes (CAR-T) and NK cells (CAR-NK) has allowed the design of effective therapies against lymphoproliferative diseases and has recently achieved success against solid tumors. Given their success, several researchers set out to …
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Analysis of Adenosine 2a Receptors During the Immune Recognition of Foreign and Self-Antigens
… primary response to vaccination and during self-antigen recognition in the context autoimmunity. Administration of A2aR agonist CGS-21680 (CGS) can alter CD4 T cell differentiation by diverting helper T cells away from a germinal center follicular helper T cells (GC-Tfh) linage that promotes the …
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Biological effects of trogocytosis on CD4+ T lymphocytes
<p>Antigen recognition by CD4+ T cells leads to large-scale spatial and temporal molecular redistributions, forming the immunological synapse. We have previously shown that upon dissociation, T cells capture large membrane fragments from antigen-presenting cells directly from the immunological …
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Biological effects of trogocytosis on CD4+ T lymphocytes
<p>Antigen recognition by CD4+ T cells leads to large-scale spatial and temporal molecular redistributions, forming the immunological synapse. We have previously shown that upon dissociation, T cells capture large membrane fragments from antigen-presenting cells directly from the immunological …
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Efficient New Computational Protein Design Algorithms, with Applications to Drug Resistance Prediction and HIV Antibody Design
… replication, molecular transport, catalysis, and antigen recognition. Protein function is determined by three dimensional structure, which is largely determined by amino acid composition. The functional diversity of known proteins suggests that nature can support a much larger set of proteins than …
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Design of Novel Antigen-Specific Immunotherapies for the Treatment of Autoimmune Disorders
… systems – the immune system. A dysregulation of antigen recognition is at the center of autoimmune disorders, and can occur in a variety of host tissues throughout the body. Further complicating these diseases is the high degree of variability in terms of clinical manifestation. Traditional …
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Elucidating the molecular mechanisms of p110δ activation in T cell antigen receptor signalling
… are activated in immune cells downstream of the antigen recognition receptors, the signals from which are crucial for the development, differentiation and activation of lymphocytes. Engagement of the T cell antigen receptor (TCR) initiates a signalling cascade leading to the rapid induction of …
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Genome-scale identification of cellular pathways required for cell surface recognition
… proteins, glycans, and lipids - mediate cellular recognition events, initiation of signalling pathways, and the regulation of processes important for the normal development and function of multicellular organisms. Interactions mediated by cell surface receptors can be challenging to detect in …
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Dissociated expression of granzyme B and IFN-gamma by T lymphocytes in HIV-1 infected individuals and its implications for Tc1 effector diversity
… of CD8+ cells and its secretion is induced by antigen recognition of these cells. Following entry into the cytosol GzB induces apoptosis in the target cells. It was measured whether GzB release by individual CD8+ cells is accompanied by the secretion of IFN-gƒnƒnand of other cytokines. HIV …
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Regulation of Human Cytotoxic T Lymphocyte Functions by IL-12
… infected cells. Upon sensing of pathogen, antigen presenting cells secrete innate cytokines such as IL-12 and IFN-α. CTL functions are specified by both antigen recognition and innate cytokines yielding a diverse population comprised of short-term effectors and long-lived memory cells. We …
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Study of the Immune Correlates of Protection in Rhesus Macaques Vaccinated against Simian Immunodeficiency Virus
… Statistical analyses support serum IgG antibody recognition of the V2 region of viral gp120 as a mechanism of protection from acquisition. One hypothesis is that antibodies to this region might block the interaction with the integrin $\alpha4\beta7$, which protrudes from the surface of mucosal …
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Visualizing the dynamics of HIV-specific cytotoxic T-cells in extracellular matrix
… (CTLs) traffic through tissues in search of antigen and mount protective immune responses against viral infections and cancer. While molecular mechanisms of CTL antiviral effector functions have been established in vitro, they have been defined in the absence of physiological dynamics and …
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Characterizing T Cell Features of Atypical Lymphocytes for the Optimization of Adoptive Immunotherapies
<p>T lymphocytes with atypical antigen targets or mechanisms or antigen recognition have been implemented into therapeutic approaches for the treatment of disease with auspicious results. Two such populations are regulatory T cells (Tregs) and CAR (chimeric antigen receptor-modified) T cells. The …
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Lipid antigens and immunoregulatory iNKT cells in the prevention and treatment of type 1 diabetes and related autoimmune diseases
… glycoprotein CD1d plays an integral part in the recognition and presentation of lipid antigens such as α-galactosylceramide (α-GalCer) to iNKT cells, producing a variety of anti-inflammatory (T\(_H\)2) cytokines, such as interleukin-4 (IL-4), and pro-inflammatory (T\(_H\)1) cytokines, such as …
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