Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Antigen processing and presentation"”.
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Characterization of antigen processing and presentation by peptide-linked MHC class I molecules
… gewöhnlich Peptide, die aus zytosolischen Antigenproteinen durch proteasomalen Verdau generiert und anschließend vom TAP-Peptidtransporter ins endoplasmatische Retikulum transportiert werden. Es können jedoch auch endozytierte Antigene für die MHC-Klasse-I-vermittelten Antigenpräsentation …
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B Cell Signaling and Bioinformatics: Revealing Components of the MHC Class II Antigen Processing and Presentation Pathway
… of mature B lymphocytes by extracellular ligands induces phenotypic changes through complex signal transduction pathways. Gene expression is altered as a result of these changes and re-programs the cell to undergo differentiation, activation, effecter function, anergy, and/or apoptosis. Gene …
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Immune-driven positive and balancing selection in human populations
This thesis examines the evidence for positive and balancing selection on immune genes in 388 individuals grouped into thirteen geographically diverse populations. The data are high coverage whole genome sequences, many from populations that have been sparsely represented in global genetic …
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Molecular Dissection of Interferon-Gamma Treated Pancreatic Beta-Cells
… characteristic decreases in glucose sensitivity and increased cell surface expression of MHC class $\rm I\sb{A}$ in the prediabetic $\beta$-cell. Enhanced expression of the MHC class $\rm I\sb{A}$ antigen processing and presentation pathway and diminished insulin production appear to be distinct …
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Elucidation of a Macrophage Cell Surface Receptor With Specificity for Exogenous Aromatic Hapten-Protein Antigens and Effects on Antigen Uptake and Processing
… interactions demonstrated that the kinetics of antigen uptake was dependent on the extent of receptor crosslinkage at the cell surface as well as on the accessibility of the ligand groups. Determination of the ligand-binding specificity of the macrophage receptor suggested preference for …
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Novel Mechanisms of Antigen Processing That Enhance Bcg Vaccine Efficacy
… current vaccine, BCG, has a variable efficacy and does not protect adults. It is known that BCG vaccine becomes sequestered in special phagosome compartments of macrophages that do not fuse with lysosomes. Since lysosome fusion is necessary for peptide production and T cell priming leading to …
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LPS from subgingival plaque and the periodontal pathogen Porphyromonas gingivalis, its effect on M1 and M2 macrophage responses and potential as a biomarker
… dysbiotic biofilm results in tissue destruction and ultimately tooth loss. The mechanisms which initiate the disease are poorly understood, as are the effectors which cause periods of exacerbation and remission experienced by sufferers of the disease. Lipopolysaccharide (LPS) is an archetypal …
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Investigation of ACE-overexpression in Myeloid Cell Lines through Whole-Proteome Analysis
… an important role in blood pressure regulation and is a key component of the renin-angiotensin aldosterone system (RAAS). A dipeptidyl carboxypeptidase, ACE also hydrolyses many different substrates across its N- and C-domain. This substrate variability has uncovered novel ACE function in other …
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Antigen presentation: Influence of Cell Type and Route of Antigen Uptake
… cells (DCs), which maintain tolerance and orchestrate T cell immune responses, comprise a heterogeneous group of cells. For example, in the steady state, murine spleen contains pre-DC-derived CD8+DEC-205+ and CD8-DCIR2+ conventional DCs. To examine antigen processing and presentation in …
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Diversity and Evolution in the Avian Major Histocompatibility Complex
… the well-studied mammalian models of human and mouse, the chicken has one of the best-understood immune systems, largely due to the interests and investment of the commercial poultry industry. The chicken Major Histocompatibility Complex (MHC) has been particularly well-studied, since …
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Immunotoxicity of Dermal Permethrin and Cis-Urocanic Acid: Effects of Chemical Mixtures in Environmental Health
… by intradermal cis-urocanic acid, cUCA) on local and systemic immune responses, with or without co-exposure to the immunotoxic insecticide permethrin. A single exposure to cUCA caused diminished splenic macrophage phagocytosis that was persistent up to 30 days post-exposure. Five-day exposure to …
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Characterisation of TAPBPR in immune cells
Cytotoxic T-lymphocytes must recognise and respond in a highly antigen specific manner to tackle pathological threats, such as virus-infected or malignant cells. This is aided by cell surface glycoproteins called the major histocompatibility complex (MHC). MHC class I (MHC-I) molecules are …
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Exploiting the Molecular Mechanisms of TAPBPR for use in Cancer Immunotherapy
TAPBPR is a chaperone within the MHC-I antigen processing and presentation pathway, responsible for shaping the immunopeptidome via MHC-I peptide editing and the recycling of sub-optimally loaded MHC-I to the peptide loading complex. As such, TAPBPR plays an essential role in the activation of the …
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Utilising recombinant TAPBPR technology to investigate MHC class I peptide editing and therapeutic applications
… crucial role in the immune response to infection and malignancy by presenting peptides to CD8+ T cells. Optimal peptide:MHC-I complexes are generated in the MHC-I antigen processing and presentation pathway. In this pathway, TAPBPR shapes the presented peptidome by catalysing peptide exchange on …
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An Investigation of Epigenetic Mechanisms Driving The Biology of Head and Neck Squamous Cell Carcinoma
<p>Head and neck squamous cell carcinoma (HNSCC) is the 6th most common cancer worldwide and is associated with significant morbidity and mortality. To date, the majority of work in the field has focused on genomic alterations such as mutations and copy number alterations. However, the clinical …
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Fasciola hepatica cystatins: recombinant production, biochemical characterisation and efficacy as vaccines
… economic importance in ruminants, such as cattle and sheep, and is now recognised as an important zoonosis. Following ingestion by the mammalian host, the parasite migrates through the intestinal wall and develops within the host liver parenchyma and then the bile ducts. We found that the …
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Defining the clinical importance of epithelial-stroma-immune signalling in colorectal cancer using a molecular pathology approach
With current standard-of-care treatments, approximately 20% of stage II and 36% of stage III colon cancer (CC) patients will experience disease relapse following surgery. Molecular and histological subtyping of CC has identified a poor-prognostic group of patients characterised by high levels of …