Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Antigen Discovery"”.
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Studies on in vitro human T cell reactivity to antigens of mycobacterium tuberculosis
Studies on Mycobacterium tuberculosis (MTB) antigens are important to improve immunodiagnostics and vaccine efficacy. A novel genome based strategy for antigen discovery is to relate what is highly expressed by bacilli in vivo or in vitro, to what is recognized by human T cells as antigens. As …
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Targeting Proteins of Aspergillus fumigatus for Monoclonal Antibody Production
… that the organisms that cause IA shed protein antigens into body fluids once inside the host. In previous studies, our lab detected PPIase, Eglc, Ecm33, TrxR and CatB in IA mouse serum and urine, using an antigen discovery platform. In our current work, we seek to develop mAbs that specifically …
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Investigation of the cancer testis antigen lactate dehydrogenase C as a CD8 T cell target
… immunotherapies. Due to their infrequency, antigen discovery is a crucial component of immunotherapeutic design. In our cohort of HGSC cases, the cancer testis (CT) antigen lactate dehydrogenase C (LDHC) is expressed in 76% of tumours (22/29). As LDHC presents with tumour specificity in …
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High-throughput tools for decoding T cell receptor specificity
… in adaptive immunity by recognizing specific antigens through their T cell receptors (TCRs). These receptors bind to peptides presented by major histocompatibility complex (pMHC) proteins, driving immune responses in cancer, infection, and autoimmunity. Understanding how TCRs recognize …
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Advancing T Cell–Based Immunotherapies: Identification of Tumor-Specific T Cell Receptor Targets and Mechanisms of Resistance in Solid Tumors
… is partly due to the absence of optimal target antigens and the development of tumor-intrinsic immune resistance mechanisms that enable evasion of immune surveillance. Overcoming these challenges will be critical to enhance the effectiveness of cancer immunotherapies and improve patient …
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Development of Diagnostic Assays for Melioidosis, Tularemia, Plague and COVID19
… The three methods were (i) In vivo Microbial Antigen Discovery (InMAD), (ii) patient serological markers and (iii) protein profiling by mass spectrometry. Converging results from the three analyses yielded putative targets to evaluate as biomarker of melioidosis or tularemia. The B. …