Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 2008 for “"Antigen"”.
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Antigen presentation: Influence of Cell Type and Route of Antigen Uptake
… and CD8-DCIR2+ conventional DCs. To examine antigen processing and presentation in vivo, antigens were specifically targeted to CD8+ and CD8- DCs using chimeric monoclonal antibodies. We find that CD8- DCs are better than CD8- DCs for presentation of exogenous antigens onto major …
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CROSS-REACTIVITY BETWEEN MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGEN AND ROUS SARCOMA VIRUS-INDUCED TUMOR ANTIGEN IN CHICKENS
… between major histocompatibility complex (MHC) antigen and Rous sarcoma virus (RSV)-induced tumor associated antigen (TAA) in chickens was investigated. The B erythrocyte allcantigen locus was the genetic marker for the MHC. B2B2 and B5B5 chickens from crosses of highly inbred lines 6-1 and 15-1 …
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The Ontogeny of Antigen-Binding Cells
<p>In order to analyze the development of antigen-specific cells, the binding of a variety of antigens by cells in the fetal, neonatal, and adult mouse was compared. The fiber-binding assay was used in many of these experiments, because it provides a simple and uniform method for studying the …
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Antigen analysis of the genus Candida
… of several species of Candida. The diffusion of antigen and antibody through the agar resulted in the formation of specific precipitates. The antisera were prepared by immunizing rabbits with formalin-killed suspensions of Candida sp. organisms. Heat and trypsin extracts of Q. guillermondi, Q. …
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Protective antigen-mediated delivery of biomolecules
… remains a key challenge today. Protective antigen, a naturally evolved protein translocase derived from Bacillus anthracis, has shown promise as a platform of protein delivery due to its ability to form a transmembrane pore that allows the cargo to have cytosolic access. We and others have …
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Enterobacterial Common Antigen Biosynthesis in Shigella flexneri
… negative bacteria and Enterobacterial Common Antigen (ECA), which is ubiquitously expressed on the OM of all Enterobacteriaceae. Both of these polysaccharides are in-part biosynthesised by separate homologs of the Wzy-dependent pathway, the most common bacterial polysaccharide biosynthetic …
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Methods to Study Antigen-Specific B cells
… of cells that can recognise a vast array of antigens. Studying the antigen-specific B cell repertoire is important for our understanding of infection, vaccination, and autoimmunity as it can help us gain insights into how protective or auto-reactive antibodies are generated. Furthermore, …
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Biolithography : selective joining using antibody-antigen reactions
… is based on selective joining using antibody- antigen reactions, where the selectively is based on the thermal sensitivity of such proteins. Antibodies and antigens can be chemically immobilized to a variety of substrate materials: polymeric, ceramic and metallic. In the present investigation, …
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The analysis of B cell antigen receptor (BCR) mutants deficient in antigen-independent signaling reveals novel BCR-associated proteins
The B cell antigen receptor (BCR) is composed of the membrane-bound immunoglobulin (mIg) <br>and the Ig-alpha/Ig-beta heterodimer and plays a central role in development, survival, and activation <br>of B lymphocytes. During B cell development, the BCR seems to be able to generate signals in <br>an …
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A Flagellin-Poxvirus Antigen Vaccine: Strengths and Limitations
… adaptive immune responses to a variety of antigens. The vaccinia virus antigens L1R and B5R are highly immunogenic in the context of the parent virus, but recombinant forms of the proteins are only weakly immunogenic. Therefore, we evaluated the response to these antigens when flagellin was …
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Silica based immunoassays for a covalently attached antigen
… was developed using a monoclonal antibody and anantigen covalently immobilized on silica, showing that silica is a potentially useful assay substrate. Silica beads prepared from tetraethyl orthosilicate (0.78 pmdiameter) and fused quartz slides were thoroughly cleaned and modified with …
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Characterization of the Paraneoplastic Cerebellar Degeneration Antigen Cdr2
… related (cdr) genes encoding putative antigens were previously identified using PCD antisera. We have demonstrated that cdr2, which encodes a cytoplasmic coiled-coil leucine zipper protein, is the only cdr gene expressed in PCD-associated tumors, and is therefore the true PCD tumor …
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Human Chimeric Antigen Receptor Macrophages For Cancer Immunotherapy
Despite recent landmark advances in chimeric antigen receptor (CAR) T cell immunotherapy for the treatment of human cancer, metastatic solid tumors remain an intractable challenge. Myeloid cells are actively recruited to the tumor microenvironment (TME), where tumor associated macrophages (TAMs) …
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Characterization of a Novel Prostate Tumor-Associated Antigen
… TURP-27 and HNK-1 have been shown to detect antigens that are heavily expressed by benign prostatic hyperplasia (BPH) and carcinoma of the prostate (CaP). Western blot analysis of prostate extracts, showed that MAb TURP-27 and MAb HNK-1 bound glycoproteins of 180, 140, 120, 100, 90 and 69 …
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