Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Antifungal compound"”.
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The mode of action of Epicoccum derived antimicrobials
Current antifungal drugs possess two major limitations: i) emergence of fungal strains that are resistant to their antifungal modes of action, and ii) toxic side effects of the drugs caused by lack of selectivity towards fungal targets. One option to overcome these limitations is thought to be the …
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Inhibition of Mycelial Growth and Reproduction of Phytophthora Megasperma F. Sp. Glycinea by Trichothecin Produced by Trichothecium Roseum
… to be due to the production of trichothecin, an antifungal compound.
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Isolation and Characterization of Bioactive Metabolites from Endophytic Fungi of Pinus Strobus
… Canada for screening of bioactive metabolite compounds. Metabolite isolation and characterization of three bioactive strains yielded the dibenzofuran derivative porric acid C (1), one butyrolactone derivative (2), one glucopyranosol derivative (3), one furfuryl ether derivative (4), four …
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A Convenient Synthesis of Pyrrolnitrin and Related Halogenated Phenylpyrroles
… details a straightforward synthetic route to the antifungal compound pyrrolnitrin 1.2, along with several analogous halogenated phenylpyrroles. The proposed synthetic protocol involved the Suzuki-Miyaura cross-coupling of appropriately halogenated pyrrole pinacolboronate esters and aryl compounds. …
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An Analysis of the Response of Aspergillus fumigatus and Candida albicans to Caspofungin
… patients. Caspofungin is a recently introduced antifungal compound that has good efficacy against these fungi with minimal side effects. The aim of the work presented here was to characterise the response of A. fumigatus and C. albicans to caspofungin. The results obtained demonstrated that …
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Investigating the biosynthesis of fosfazinomycin
… a variety of bioactivities. Further, these compounds often contain unusual structural features, which arise from remarkable enzymatic transformations. One example comes from fosfazinomycin, an antifungal compound bearing a unique phosphonohydrazide (C-P-N-N-C) linkage that joins a …
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Fundamental study of natural and synthetic antimicrobial peptides as novel preservatives against fungal food spoilage
… conjugation with a lauric acid, synergistic antifungal activity is observed with strong improvements of peptide resistance. However, the price to pay for such improvement is a strong increase of toxicity. Based on rational design with key determinants of antifungal activity, a novel …
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Structural and biochemical studies on enzymes involved in natural product biosynthesis and cellular respiration
… biosynthesis and abundance. Many of these compounds have been found to have pharmaceutical and industrial applications, and have been used as the basis for derivatives that are already being used for large scale production. Despite initial availability, there now is an urgent need to …
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Toward the Synthesis of CAY-1, an Antifungal Steroidal Saponin
… be a pressing need for the development of novel antifungal compounds since there are currently only 13 compounds licensed for the treatment of invasive fungal infections and antibiotic-resistant strains have been emerging. CAY-1 is an antifungal steroidal saponin which was isolated from the fruit …