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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Antifungal agents"”.
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Two Antifungal Agents From Streptomycetes
Made available in DSpace on 2014-12-05T20:30:16Z (GMT). No. of bitstreams: 1 6305079.pdf: 3650897 bytes, checksum: d89c27c886778daabd3d0023e1aa05ae (MD5) Previous issue date: 1963
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Discovery and development of novel antifungal agents for the treatment of Candida auris infections
… infections are limited to three main classes of antifungal drugs: azoles, polyenes, and echinocandins. The emergence of new fungal species, such as Candida auris, which displays high resistance and mortality rates (30-60%), has further complicated treatment efforts. Thus, there is a critical need …
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Cyclic and Linear Peptides Containing Tryptophan and Arginine Residues as Cell-Penetrating Peptides and Antifungal Agents
… fumigatus to determine the optimal sequence for antifungal activity. Linear and cyclic peptides showed minimum inhibitory concentrations (MIC) ranging from 6.25 to 50 µg/mL. Minimum Fungicidal concentration (MFC) values were 25 to 50 µg/ml against C. albicans and C. pararpsilosis. Among linear …
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Susceptibility Testing of Pathogenic Fungi With a Radiometric System
… dermatitidis, Sporothrix schenckii) to selected antifungal agents. Antifungal agents evaluated were Amphotericin B, 5-fluorocytosine, Nystatin, Ketoconazole, Miconazole, Terconazole, and Itraconazole. The instrument used to measure amount of radioactive carbon dioxide generated by fungal …
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Phenotypic and molecular antifungal susceptibility testing of yeast isolates from Pretoria
Antifungal drug resistance is a growing problem. Several mechanisms contribute to the development of resistance to antifungal agents. In South Africa, little is known about the antifungal susceptibility of local yeast isolates. The aim of this study was therefore to determine the antifungal …
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Synthesis and Antifungal Evaluation of Barbiturate Saponins And Progress Towards Cysteinyl Metal Peptides
… There is a critical need to develop new antifungal agents because of increasing resistance to the common antifungal drugs.</p> <p>In the first part of this dissertation, methods for preparation of novel barbiturate saponin as antifungals and their biological activities would be described. …
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Evaluating the Fungistatic and Fungicidal Activities of Bianthrones as Synthetic Intermediates to Novel Hypericin Analogues.
There is increasing demand for new and improved antifungal agents due to an increase in fungal infections and diseases in patients being resistant to previous antifungals. The focus of this research is on the synthesis of anthraquinone, anthrone, bianthrone and hypericin type derivatives and the …
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Nanoparticles from microalgae for environmental and biomedical applications
… showcasing their efficacy as innovative antifungal agents. The investigation employs various analytical techniques, such as GCMS, FTIR, XRD, SEM, TGA, and zeta potential measurements, to characterize the properties of the synthesized nanomaterials. Notably, silver nanoparticles exhibit …
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ΜΙΚΡΟΒΙΟΛΟΓΙΚΟΣ ΕΛΕΓΧΟΣ ΑΝΤΙΜΙΚΡΟΒΙΑΚΩΝ ΠΑΡΑΓΟΝΤΩΝ
… E. COLI AND P. AERUGINOSA. IN THE THIRD PART (ANTIFUNGAL AGENTS), WE STUDIED 5 CHEMICAL COMPOUNDS: IRGASAN DP300, O-PHENYLPHENOL, (IRGASAN, CETRIMIDE), MIRANOL CM AND MIRABOL A 15. THEIR ACTIVITY WAS DETERMINED BY THE DILUTION- NEUTRALIZATION METHOD NF T72-200. THE TESTED MICROORGANISMS WERE: …
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Quantitation of Anti-Infectious Disease Molecules Utilizing Paper Spray Mass Spectrometry
Suboptimal dosing of anti-microbial agents increases the likelihood of therapeutic failure and resistance. Dosing optimization, while an attractive approach to combat these issues, is difficult to implement due to the different pharmacokinetics of each individual. These limitations highlight the …
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!Development of small molecule therapeutics against anti-infectious and anti-cancer drug resistance via structure-based drug design
… with the developing of antibiotics, anticancer agents, and antifungals and reveal critical insights into the corresponding structure-activity relationships (SARs).Phospho-N-acetyl-muramyl-pentapeptide translocase (MraY) is an important membrane enzyme involved in the early-stage biosynthesis of …
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Intracellular parasitism of macrophages by Cryptococcus
… from the immune system and protected from antifungal agents, thus achieving long-term latency. This project has also provided a possible explanation for the molecular cause of a recent C. gattii outbreak on Vancouver Island, Canada. We found that isolates from the outbreak have dramatically …
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ANTIFUNGAL ACTIVITY OF NATURAL AND NATURAL-INSPIRED BIOACTIVE COMPOUNDS TO CONTROL THE RICE BLAST FUNGUS
… potential as an environmentally friendly antifungal agent. Stilbene derivatives merged with strobilurin pharmacophores showed activity comparable to commercial fungicides, though their low efficacy against resistant strains suggested retention of strobilurin-like mechanisms. Ferroptosis, …
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Challenging the Paradigm of Clinical Triazole Resistance in Aspergillus fumigatus
… more than 60% of all cases. Currently, the only antifungal agents available with consistent activity against A. fumigatus are the mold-active triazoles and amphotericin B, of which the triazoles commonly represent both front-line and salvage therapeutic options. Unfortunately, the treatment of …
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Responses to Antifungal and Alkaline pH Stress in Human Fungal Pathogens
… presented by different environments.</p><p>Antifungal drug treatment presents a significant stress for the opportunistic pathogen Cryptococcus neoformans. Currently, there are limited treatment options for cryptococcal infections. Researchers have been working toward identifying drugs that …
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Targeting final steps of sugar nucleotide biosynthetic pathway against <i>Aspergillus fumigatus</i>
… azoles, echinocandins) are available for antifungal treatment with multiple issues including drug resistance, toxicity and undesirable drug-drug interactions. In recent decades, pharmaceutical companies have carried out research for novel antifungal agents with modest progression, which is …
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FUSARIUM MUSAE, A NEW POTENTIAL TRANSKINGDOM PATHOGEN.
… their demonstrated inherent resistance to many antifungal agents and yet global incidence rates of fusariosis remain unclear due to insufficient studies. Many Fusarium species are recognized for their transkingdom pathogenicity. Among the most recently identified is F. musae, a causative agent …
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Validation and Application of a Novel Target-Based Whole-Cell Screen to Identify Antifungal Compounds
… has not yet been exploited to develop uniquely antifungal agents. Although there have been attempts to develop fungal-specific inhibitors of dihydrofolate reductase, the protein itself has not been unequivocally validated as essential for fungal growth or virulence. The purpose of this study was …
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Exploring the potential of Antifungal Peptides to suppress the Pathogenicity of the Botrytis cinerea and Grey Mould Disease in Grapes and Strawberries
… number of copies) exhibited different levels of antifungal activity against different life stages of Botrytis fungal pathogen which can be attributed to the wide structural variations of cell walls, size and shape between mycelium structure and conidial spore cells of Botrytis. At the same time, …
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Analysis of a Cotton Gene Cluster for the Antifungal Protein Osmotin
Three overlapping genomic clones covering 29.0 kilobases of cotton DNA were found to encompass a cluster of two presumptive osmotin genes (OSMI and OSMII) and two osmotin pseudogenes (OSMIII and OSMIV). A segment of 16,007 basepairs of genomic DNA was sequenced from the overlapping genomic clones …
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