Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Antifungal Resistance"”.
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Transcriptional Regulation of Azole Antifungal Resistance in Candida albicans
… virus (HIV). OPC is usually treated with azole antifungals, a class of antifungals that target ergosterol biosynthesis, at low doses over long periods of time. This course of treatment allows for the development of azole resistance.</p> <p>Two major mechanisms of azole resistance exist in C. …
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Transcriptional Regulation of Azole Antifungal Resistance and Tolerance in Candida Glabrata
<p>Azole antifungal resistance has emerged as a significant problem in the management of infections caused by fungi including <em>Candida</em> species. In recent years, <em>Candida glabrata</em> has become the second most common cause of mucosal and invasive fungal infections in humans second to …
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Alternative Carbon Utilization As A Virulence Determinant For Candida Albicans
… which has a mortality rate reaching 50%. As antifungal resistance continues to rise, it is critical that I understand the molecular basis of disseminated fungal infections.</p> <p>The phagocytes of the immune system are especially important for preventing disseminated infection. Macrophages …
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Molecular Analysis of Phenotypic Diversity in Human Fungal Pathogens
… thwart therapeutic regimens by rapidly evolving resistance to antifungal drugs, and their ability to readily adapt to the hostile conditions experienced in a mammalian host. Candida species can colonize various niches in the human body making them common commensals of the mucosal microbiota, …
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Loss of the SAC Components SldA Kinase or SldB or in vitro Adaptation to Triazole Produces Aneuploidy Associated with Triazole Heteroresistance in Aspergillus fumigatus
… of the fungal cell membrane. Unfortunately, resistance to this class of medical therapeutic has arisen globally and now threatens the future usefulness of these compounds for antifungal treatment. Infection with A. fumigatus that has acquired triazole resistance increases an already high …
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A Cloning-Free Recyclable System for CRISPR-Cas9 Mediated Mutant and Reversion Construction in Candida albicans Clinical Isolates
… in clinical isolates plays an important role in antifungal resistance, virulence, and pathogenicity. These recent discoveries highlight the need for genetic tools that are capable of investigating genes in multiple strain backgrounds. Here we build on the SAT1-flipper method and combine it with …
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Probing the role of histone acetylation in the evolution of pathogenicity in <i>Candida glabrata</i>
… challenges due to the former’s intrinsic antifungal resistance. <i>C. glabrata </i>also possesses a particularly interesting phylogeny, being a pathogen that is closely related to the non-pathogenic yeast <i>S. cerevisiae</i>. This makes <i>C. glabrata</i> a valuable model species to …
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ERG11-Mediated Azole Resistance in Candida albicans
… with fungal infections, the emergence of antifungal resistant clinical isolates creates significant problem in regards to antifungal prophylaxis and empirical treatment strategies. Antifungal resistance is associated with high mortality rates and hefty medical costs. The azole-antifungal …
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Investigating MCE Chemical Library Drugs for Combinational Therapies for Clinical Aspergillus fumigatus isolates
… patient outcomes. Furthermore, our lessening of antifungal development combined with increasing resistance generates a feasible scenario where only last resort options are viable. This has prompted the World Health Organization (WHO) to declare this pathogen a "critical priority" due to increased …
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Características clínicas, microbiológicas y desenlaces de la candidiasis invasora en adultos en un hospital de alta complejidad
Introducción: La candidiasis invasora es una infección grave, asociada a la atención de la salud y con alta mortalidad generada por Candida spp. Esta infección compromete cualquier órgano, principalmente el lecho sanguíneo. Es causada por Candida spp.; siendo más común Candida albicans, pero tiende …
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Discovery and development of novel antifungal agents for the treatment of Candida auris infections
… infections are limited to three main classes of antifungal drugs: azoles, polyenes, and echinocandins. The emergence of new fungal species, such as Candida auris, which displays high resistance and mortality rates (30-60%), has further complicated treatment efforts. Thus, there is a critical need …