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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 289 for “"Antifungal"”.
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Tetrin, a New Antifungal Antibiotic
Made available in DSpace on 2014-12-05T20:30:08Z (GMT). No. of bitstreams: 1 5900558.pdf: 5129560 bytes, checksum: c10299eb09840db60db3f3fbf3ff20d4 (MD5) Previous issue date: 1958
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Two Antifungal Agents From Streptomycetes
Made available in DSpace on 2014-12-05T20:30:16Z (GMT). No. of bitstreams: 1 6305079.pdf: 3650897 bytes, checksum: d89c27c886778daabd3d0023e1aa05ae (MD5) Previous issue date: 1963
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Killer yeasts as antifungal biocontrol agents
The ability of killer yeast to inhibit the growth of fungi, specifically wood decay fungi, has been investigated. An initial broad screen of 17 yeast versus 17 fungi demonstrated that killer yeast can and do exhibit antagonistic as well as growth stimulatory affects on fungi. Yeast from the …
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Mechanism of Antifungal Action of Patulin
Made available in DSpace on 2014-12-09T18:06:26Z (GMT). No. of bitstreams: 1 6607813.pdf: 4172421 bytes, checksum: 350ba13848135f8be7f4787723e51098 (MD5) Previous issue date: 1966
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Synthesis and Antifungal Evaluation of Spirostane Saponins
<p> <p>Methods for the preparation of novel antifungal saponins have been investigated in</p> <p>order to further explore their medicinal utility and provide the opportunity to synthesize</p> <p>their derivatives.</p> <p>Through this work, several partially protected stereoisomers of …
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Targeting Coenzyme A Biosynthesis for Antifungal Development.
… limited by the modest efficacy of the available antifungal drugs: the azoles, echinocandins, and amphotericin B. Approximately one-third of patients with disseminated Candida infections are non-responsive to treatment with the azoles, and favorable response rates are just 52-73% for the …
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Mechanism of Action of the Antifungal Antibiotic Pyrrolnitrin
Made available in DSpace on 2014-12-09T18:06:31Z (GMT). No. of bitstreams: 1 6910867.pdf: 4251027 bytes, checksum: a9373d3191b464067a8723e2725cbb91 (MD5) Previous issue date: 1968
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Examining How Non-Antifungal Medications Impact Host-Fungal Interactions
… the availability of three major classes of antifungal drugs. Furthermore, millions more suffer debilitating infections of the mucosal membranes or destructive subcutaneous mycoses. One of the most common IFIs is invasive candidiasis, mostly commonly caused by Candida albicans infections, …
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Transcriptional Regulation of Azole Antifungal Resistance in Candida albicans
… virus (HIV). OPC is usually treated with azole antifungals, a class of antifungals that target ergosterol biosynthesis, at low doses over long periods of time. This course of treatment allows for the development of azole resistance.</p> <p>Two major mechanisms of azole resistance exist in C. …
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Anticarcinogenic, Antitumor, and Antifungal Properties of Allium Sativum (Garlic)
… immune enhancing, antitumor and antifungal effects of a crude extract and organosulfur compounds of garlic were determined. Diallyl sulfide (DAS), and ajoene each at 100 /xg/ml, and garlic extract (GE, 12.5 mg/ml) inhibited rat liver 9000 X g supernatant (S- 9) dependent …
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Exploiting fitness trade-offs to prevent antifungal drug resistance
… In my thesis, I tested the hypothesis that antifungal drug resistance is the outcome of diverse tradeoffs between the fitness benefits of resistance mutations and their costs upon the adaptive cellular factors that enable the evolution of new traits. I also pursued the discovery of novel …
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Antifungal Immune Responses and Inflammation in the Cystic Fibrosis Airways
… the host-fungal interactions showed that the antifungal immune responses are fungus and fungal morphotype specific, and that the differences caused by the impaired function of the CFTR protein varies between host cell types. Aspergillus hyphae are more potent inducers of ROS than Aspergillus …
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Antifungal Immune Responses and Inflammation in the Cystic Fibrosis Airways
… the host-fungal interactions showed that the antifungal immune responses are fungus and fungal morphotype specific, and that the differences caused by the impaired function of the CFTR protein varies between host cell types. Aspergillus hyphae are more potent inducers of ROS than Aspergillus …
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Toward the Synthesis of CAY-1, an Antifungal Steroidal Saponin
… be a pressing need for the development of novel antifungal compounds since there are currently only 13 compounds licensed for the treatment of invasive fungal infections and antibiotic-resistant strains have been emerging. CAY-1 is an antifungal steroidal saponin which was isolated from the fruit …
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The Molecular Mechanisms of Antifungal Drug Resistance In Pathogenic Fungi
… individuals. Azoles are the most common antifungals used in treating these infections. The most significant mechanisms of azole resistance include alterations or overexpression of the target enzyme, and overexpression of at least three distinct efflux pumps. Recently, azole-resistant …
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Chemoenzymatic synthesis of an analogue of the potent antifungal mycosubtilin
<p>Mycosubtilin is a naturally occurring antifungal obtained from <em>Bacillus subtilis</em> that also displays limited antibiotic activity. Structurally, mycosubtilin is a macrocycliclipoheptapeptide of sequence Asn-Tyr-Asn-Gln-Pro-Ser-Asn, with the N-terminal Asn joined by a β-amino fatty acid. …
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Antifungal invertebrate bioencapsulation: a potential solution to poor patient compliance
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-12-01
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Characterisation of a maize mutant deficient in antifungal kauralexin accumulation
Fusarium verticillioides and Cercospora zeina are two economically important fungal pathogens of maize in Southern Africa. Phytoalexins are low molecular weight anti-microbial compounds produced in plants in response to pathogen infection. In maize, two classes of non-volatile terpenoid …
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Analysis of a Cotton Gene Cluster for the Antifungal Protein Osmotin
Three overlapping genomic clones covering 29.0 kilobases of cotton DNA were found to encompass a cluster of two presumptive osmotin genes (OSMI and OSMII) and two osmotin pseudogenes (OSMIII and OSMIV). A segment of 16,007 basepairs of genomic DNA was sequenced from the overlapping genomic clones …
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