Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Antiestrogenic"”.
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Estrogenic and Antiestrogenic Regulation of Cell Proliferation and Tissue Growth
Estrogenic and antiestrogenic responses were investigated in human breast cancer cells and in the rat uterus. I studied the regulation of ornithine decarboxylase (ODC) activity and polyamine concentrations by E2 and antiestrogens (AE) as an aid to understanding the dissimilar effects of E2 and AE …
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Effects of Gestational and Lactational Exposure to 2,3,7,8-Tetrachlorodibenzo-P-Dioxin or Coplanar PCBs on Reproductive Development and Sexually Dimorphic Behaviors in Rats
… masculinized in both studies. TCDD and PCBs have antiestrogenic effects and masculinization of saccharin preference in females could be due to the antiestrogenic effects of these chemicals in the parabrachial nucleus of female rats.
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Bioactivities of Antiestrogens and Antiestrogen Metabolites in the Rat and Mouse
… to metabolites having greater estrogenic and antiestrogenic potency than their parent compounds. This laboratory has revealed that two potent nonsteroidal antiestrogens,
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Differential Endometrial Responses of Primates vs Rodents: Screening for Antiproliferative Effects of Antiprogestins
… uterine bioassay, to identify the noncompetitive antiestrogenic/antiproliferative effects of mifepristone.</p> <p>Long-term ovariectomized monkeys were exposed to exogenous 17β-estradiol (E2) and mifepristone in doses and regimes already demonstrated to curtail endometrial growth (Wolf et al., …
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Lifetime Occupational Exposure to Endocrine-disrupting Chemicals and Postmenopausal Breast Cancer Risk: A Montreal-based Case-control Study (2008-2011)
… a directed acyclic graph. Results: Ever exposure antiestrogenic EDCs (OR=1.40 [0.99, 2.00]) and anti-androgenic EDCs (OR=1.49 [1.08, 2.08]) similarly increased postmenopausal breast cancer risk compared to estrogenic (OR=1.16 [0.82, 1.63]). This trend was also observed with the average …
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Tissue-Specific Mediation of Estrogen-Induced Epithelial Events by the Estrogen Receptor in Female Reproductive Tract Organs
… mice were exposed to the suspected antiestrogenic environmental contaminant and aryl hydrocarbon receptor (AhR) ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), normal E2-induced uterine epithelial function was inhibited. However, uterine epithelial function in mice that lack AhR …
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Estrogenic Activity of the Polybrominated Diphenyl Ether Flame Retardant Mixture DE-71
… concentrations (≥ 5x10-5 M), ortho-OH-PBDEs were antiestrogenic in the ERE-luciferase assay. In conclusion, DE-71 behaves as a weak estrogen in both MCF-7 breast cancer cells and ovariectomized adult mice. Mice strain, treatment route and duration determined if DE-71 was estrogenic. BALB/c mice …
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Investigating the Involvement of RNA-Binding Protein ZFP36L1 in Breast Cancer Progression
… of ZFP36L1 in combination with tamoxifen, an antiestrogenic drug used as a standard treatment for the luminal breast cancer subtype. To explore functional aspects of ZFP36L1, we generated CRISPR Cas9-derived knockout of ZFP36L1 in the MCF-7 breast cancer cell line, characterised by luminal A …
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Elucidation of the Molecular Mechanisms Underlying Estrogen-Mediated Estrogen Receptor Activation
… metabolites, some of which exhibit more antiestrogenic effects than tamoxifen itself. In this study, we demonstrate that the more antiestrogenic effect of endoxifen versus tamoxifen is due post-translational modification by SUMO and inhibition of SUMO derepresses endoxifen’s …