Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 56 for “"Antidiabetic"”.
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Design, synthesis and biological evaluation of antidiabetic agents
… Consequently, there exists a need for novel antidiabetic agents for the treatment of T2D. The retinol transporter, RBP4, is a possible target for the treatment of T2D as elevated levels of this protein are found in T2D sufferers. Compounds that reduce the levels of RBP4 in vivo have been …
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Isolation and characterization of antidiabetic constituents of Bridelia Micrantha
… malaria. Previous studies have demonstrated the antidiabetic activities of B. micrantha crude extracts in in vivo studies. However, there are no studies on the compounds responsible for the antidiabetic activity of the plant. The purpose of this study was to isolate and characterize the …
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Biological activities and antidiabetic potential of novel peptides from frog secretions
The utilisation of natural products as drugs for the treatment of diseases and injuries has developed for thousands of years, but the current pharmaceutical system is predominately occupied by chemical-based drugs, while natural products are rarely applied. Since the widespread of antibiotic …
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Determination of the in vitro antidiabetic potential of a polyherbal commercial tea
… and hypoglycaemic activity of a commercial ‘antidiabetic’ tea mixture (Diabetea) and its individual constituents: Achillea millefolium L. (Yarrow), Agathosma betulina Bartl. & Wendl. (Buchu), Salvia officinalis L. (Sage), Taraxacum officinalis L. (Dandelion), Thymus vulgaris L. (Thyme), …
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Impact of Medicaid Expansion on Adherence to Antidiabetic Medications Among Low-Income Adults
… related sequelae. Uninterrupted therapy on antidiabetic medications can postpone or prevent the damaging and costly complications associated with the progression of diabetes; however, many low-income individuals face significant barriers adhering to drug regimens. Medicaid, the primary …
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Antidiabetic activity of Schkuhria pinnata – Biological screening, PK analysis and mode of action
… pinnata (Lam.) Kuntze was investigated for its antidiabetic potential. Initial screening of two different solvent extracts of S. pinnata identified an aqueous extract that lowered blood glucose concentrations in a hyperglycaemic streptozotocin-induced diabetic rat. The classical bioassay …
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In vitro antidiabetic and antimicrobial properties of Ocimum species (Ocimum basilicum and Ocimum sanctum) (L.)
Submitted in fulfilment of the requirements of the degree of Master's in Technology: Biomedical and Clinical Technology, Durban University of Technology, Durban, South Africa, 2016.
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Enhancing health equity in antidiabetic medication use and diabetes care outcomes through data science approaches
… of cases attributable to type 2 diabetes (T2D). Antidiabetic medications play a central role in glycemic control and in preventing or delaying diabetes-related complications. Understanding differences in antidiabetic medication use patterns and promoting sustained adherence are essential for …
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Development, evaluation, and In-vitro assessment of artificial intelligence antidiabetic predictive models from α-glucosidase inhibitors
Background: The global rise in the prevalence of diabetes mellitus (DM) poses a significant health challenge, necessitating effective therapeutic interventions. Type 2 DM (T2DM) remains the most prevalent form of diabetes, accounting for over 90% of cases. Intestinal α-glucosidase enzymes, located …
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The antidiabetic properties of four plants grown in India and KwaZulu-Natal, South Africa, suitable for diabetic management
… of M.charantia and A.esculentus had maximum antidiabetic potential compared to the other plant extracts. The aqueous extract of M.charantia and A.esculentus fruits, at a dose of 300 mg/kg body weight, showed a statistically significant lowering of the glucose level of alloxan induced diabetic …
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THE ROLE OF HYPOGLYCEMIC AGENTS IN AMELIORATING COGNITIVE FUNCTIONS AND PSYCHIATRIC SYMPTOMS: FROM THE PSYCHIATRIC PATIENT TO EVIDENCE-BASED AND PHARMACOEPIDEMIOLOGIC APPROACHES FOR SUPPORTING THE CLINICAL PRACTICE
… involving both brain and systemic responses. Antidiabetic drugs such as metformin and drug targeting Glucagon-Like Peptide-1 (GLP-1) are being proposed for psychiatric and cognitive treatments, although their use for non-diabetic purposes remains debated. Methods: The role of antidiabetic …
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Avaliação do potencial biotecnológico de bactérias láticas para produção de biomulsificantes, bacteriocinas e lipase
… bioactive metabolites, which have antioxidant, antidiabetic, antimicrobial, and emulsifying activities. Therefore, the present study aims to evaluate the biotechnological potential of lactic acid bacteria regarding the production of biosurfactants/bioemulsifiers, lipase and bacteriocins. …
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Exploring new chemical entities from traditional medicine: Docking, synthesis and specific bioactivities
… deals with the identification of small-molecule antidiabetic compounds from the TCM plant, Goji (Lycium barbarum and Lycium chinense), widely used for treating various diseases including diabetes and hypertension Current clinical antidiabetic drugs, like rosiglitazone display severe side effects …
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The upper small intestinal microbiota regulates nutrient sensing pathways to influence glucose homeostasis
… microbiota and/or nutrient sensing mediate the antidiabetic action of metformin is currently unknown. Through Study 1 and 2 we demonstrate that upper small intestinal lipids and glucose activate nutrient sensing pathways to regulate glucose homeostasis in healthy rodents, while HFD-feeding …
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Antioxidant activity and phytochemical evaluations of selected medicinal plants
… anti-inflammatory, hyperglycaemic, antidiabetic) along with the shown antioxidant behaviour explain the traditional medicinal values of the plant. Cassia alata L crude extract and its fractions showed potent radical scavenging activity against formation of lipid peroxide radicals. …
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The Art of Modeling and Simulation of Multiscale Biochemical Systems
… level. This new discovery sheds light on antidiabetic medication. In order to study the stochastic dynamics of the insulin secretion pathway, we first apply the hybrid method to model the discrete events in the insulin secretion pathway. Based on the hybrid model, a probability based …
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Receptiveness to Social Support: Understanding the Conflicting Relationship Between Social Support and Medication Adherence in Adults with Type 2 Diabetes Mellitus
… the significance of diabetes management. Antidiabetic medications are utilized in diabetes management to enhance glycemic control. Although adherence to antidiabetic medications is crucial, non-adherence is common and attributed to a variety of factors, such as social support. While social …
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(ASYMMETRIC) PHOTOCATALYSIS UNDER HOMOGENEOUS AND HETEROGENEOUS CONDITIONS - OPTIMIZATION IN CONTINUO, NOVEL CATALYTIC REACTORS AND MATERIALS
… it in the telescoped synthesis of an approved antidiabetic drug – Mitiglinide in high yield and satisfactory enantioselectivity.
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Effects of Ultrasonication on the Antioxidant and Anti-diabetic Properties of Hydrolyzed Oat Proteins
… proteases produced hydrolysates with notable antidiabetic activity (DPP-4 and alpha-amylase inhibition) but this was not influenced by the difference in polypeptide compositions.
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The Effectiveness of Beta-blockers after Myocardial Infarction in Patients with Type 2 Diabetes
… under real-world conditions. New users of antidiabetic agents with MI were identified by prescription records and ICD-9 codes. Drug exposures were determined from prescription records. Hospitalizations and deaths were documented over 9 years. Re-hospitalization after MI was studied as a …
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