Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"Antidepressant response"”.
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Translational Regulation in Excitatory Neurons Controls Stress Reactivity and the Antidepressant Response to Ketamine
… axis activation. Ketamine produces rapid antidepressant effects, partly through mammalian target of rapamycin complex 1 (mTORC1) signalling, which phosphorylates 4E-Binding Protein 1 and 2 (4E-BPs) to promote synaptic plasticity. This thesis examines the role of 4E-BP signalling in …
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Advancing Precision Medicine in Psychiatry: Genetic Insights into Antidepressant Treatment Outcomes
… with substantial interindividual variability in antidepressant treatment response and tolerability. Genetic variation, particularly in pharmacokinetic genes such as CYP2C19 (drug metabolizing enzyme) and ABCB1 (encoding the drug-efflux transporter P-glycoprotein), and broader polygenic liability …
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Unravelling Variability in Antidepressant Outcomes using Pharmacogenetic and Pharmacokinetic Strategies
… role in the interindividual variability of antidepressant response. This PhD thesis comprises three studies that investigate how genetic variations influence antidepressant treatment outcomes. The first study analyzed data from the STOP-PD II trial (N = 171), where participants with …
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Towards Precision Medicine: Characterizing and Predicting Antidepressant Remission Heterogeneity in Late-life Depression Using Genetic Data
… disease, which impact symptomatology and response to antidepressant medication. Towards precision medicine, this thesis traverses methodologies in pharmacogenetics to identify variants associated with, and predictive of, response in older adults, specifically among those treated with the …
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Anxiety and Anhedonia in Major Depressive Disorder: The Contributing Roles of Neuroticism, Cognitive Control, and Reward Learning
… the Establishing Moderators and Biosignatures of Antidepressant Response in Clinical Care (EMBARC) study, we conducted a path analysis using structural equation modeling to model hypothesized relationships between the constructs of neuroticism, cognitive control, and reward learning and symptom …
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Novel insights into the role of the GABAB receptor in depression and anxiety
… stress (maternal separation), in modulating antidepressant like and anxiety-related behaviours. Pharmacological blockade of the GABAB receptor with CGP52432 had antidepressant-like behavioural effects. Moreover, mice lacking the GABAB(1b) receptor subunit isoform exhibited antidepressant-like …
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Overcoming Vulnerabilities of Machine Learning in Neuroimaging Applications
… augmentation method, I develop predictors of antidepressant response from pre-treatment task-based fMRI. This targets a pressing need for individualized treatment selection tools in depression care, where it currently takes weeks to months to test various medications until adequate relief is …
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Investigating the molecular underpinnings of major depressive disorder and the utility of biomarkers in the inflammatory cytokine pathway as aids for clinical diagnosis and treatment selection
… disorder.<br/>Another clinical problem is that antidepressants, the first line of treatment for<br/>MDD, are ineffective in a significant proportion of patients. The projects in this<br/>thesis address four aims: (i) the identification of novel gene-environment<br/>interactions which may …