Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 173 for “"Antidepressant"”.
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Personalizing tricyclic antidepressant treatment for major depressive disorder
Contains fulltext : 329120.pdf (Publisher’s version ) (Closed access)
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Barriers and Facilitators to Antidepressant Adherence in College Students
Introduction: Medication adherence to antidepressants prescribed to treat depressive disorders can heavily influence the effectiveness of treatment. Past research has shown that adherence to antidepressants is subject to the influence of various underlying factors that serve as both barriers and …
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Evaluation of indigenous medicinal plants with potential antidepressant effects
… numerous side-effects associated with existing antidepressant drugs. In South Africa, the use of plants to manage depression is fairly documented among different ethnic groups. The aim of this study was to review South African medicinal plants used traditionally to manage depression-like …
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Unravelling Variability in Antidepressant Outcomes using Pharmacogenetic and Pharmacokinetic Strategies
… role in the interindividual variability of antidepressant response. This PhD thesis comprises three studies that investigate how genetic variations influence antidepressant treatment outcomes. The first study analyzed data from the STOP-PD II trial (N = 171), where participants with …
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Antidepressant Persistence Before and After the Introduction of Online Renewal
… contributed to the medication persistence of antidepressant users by reducing the effort involved in renewing prescriptions. Online renewal can be considered a part of a larger programme to utilise technology to improve Finnish health care, whereas a major necessary intermediary step towards …
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Antidepressant-Like Effects of Ketamine on Fear Conditioning and Extinction
… of depression, emphasizing the need for antidepressant treatments that can effectively combat these insidious symptoms. Memory for negative emotional events can be studied in animals using fear conditioning and extinction paradigms. Fear conditioning trains an animal to associate a …
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Advancing Precision Medicine in Psychiatry: Genetic Insights into Antidepressant Treatment Outcomes
… with substantial interindividual variability in antidepressant treatment response and tolerability. Genetic variation, particularly in pharmacokinetic genes such as CYP2C19 (drug metabolizing enzyme) and ABCB1 (encoding the drug-efflux transporter P-glycoprotein), and broader polygenic liability …
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Analysis of rat brain lipids and metabolites after antidepressant drug treatment
… some of the molecular/biochemical mechanisms of antidepressant drugs with an emphasis on the relatively unexplored role of sphingolipids. For this purpose, the current study used two antidepressant drugs: the tricyclic antidepressant desipramine, and the selective serotonin re-uptake inhibitor …
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On The Future Of Antidepressant Treatments: Targeting Neurotrophic Factors And Plasticity
… have shortcomings. Despite evidence that current antidepressants elevate synaptic monoamine levels within hours of administration, these drugs require four to six weeks of daily administration before symptom relief appears. Furthermore, approximately half of patients taking typical antidepressants …
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Economic evaluations of antidepressant treatments: a national cohort study in Taiwan
… health service providers and society as a whole. Antidepressant drugs remain the mainstay of treatment for depression for most people in contact with healthcare services and the last 20 years have seen dramatic changes in antidepressant prescription patterns. Initially, there was an increase in …
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The Role of Chromatin Remodeling in Hippocampus in Depression and Antidepressant Action
… with depression and reversed by treatment with antidepressants: regulation at the level of chromatin remodeling. The technique of brain chromatin immunoprecipitation was pioneered to directly measure the in vivo modifications of histones, a form of chromatin remodeling, at gene promoter regions …
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Network mechanisms underlying susceptibility to helplessness and response to the antidepressant fluoxetine
… These conditions are frequently treated with antidepressants such as selective serotonin reuptake inhibitors (SSRI’s). However, there are individual differences in susceptibility to stress-induced psychopathologies and response to antidepressants. Therefore, there is a need to identify …
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Antidepressant effect of pramipexole in a dexamethasone induced depressive-like behavior model
Resumo: A depressão é um distúrbio psiquiátrico comum caracterizado por diversos sintomas debilitantes como a desesperança e a anedonia. Apesar de a fisiopatologia do distúrbio ainda não estar completamente elucidada, evidências demonstram a associação entre a depressão e disfunções do sistema …
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ANTIDEPRESSANT EFFECTS OF THE NTS1 AGONIST PD149163 IN THE FORCED SWIM TEST
… is a commonly used screening model for putative antidepressant medications. Drugs that have antidepressant effects in humans reliably decrease the time animals spend in an immobile posture in the forced swim test without increasing general locomotor activity as measured in an open field test. The …
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Effects of tricyclic antidepressant drugs on deprivation-induced fluid consumption in rats
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Dissociated Antidepressant and Analgesic Effects of Intravenous Ketamine in Patients with Chronic Pain
연구 배경: 최근 연구들은 저용량의 케타민 치료가 수시간 혹은 수일 안에 우울 증상을 유의하게 호전시켰음을 증명해 왔다. 본 연구는 만성 통증 환자에서 케타민이 기분에 미치는 효과를 알아보고자 시행되었다. 연구 방법: 2013년 1월, 단일 기관에서 케타민 치료를 받는 통증클리닉 외래 환자 40명이 설문에 응하였다. The Beck Depression Inventory (BDI) 가 각 대상자의 기분을 평가하기 위해 사용되었고, 이후 케타민이 1시간에 걸쳐 모든 대상자에게 정맥 투여되었다 (평균 1.2mg/kg). 우울, 불안, …
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Relationship between sunshine duration and antidepressant consumption in three Northern countries– a pharmacoepidemiologic approach
… the relationship between sunshine duration and antidepressant consumption.
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