Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Anticholinesterase"”.
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The Effect of Anticholinesterase Action on Mammalian Skeletal Neuromuscular Transmission
… to muscular contraction and the actions of anticholinesterases is presented in the Introduction. The work has been largely concerned with the irreversible inhibition of cholinesterase by ecothiopate (phospholine) at the neuromuscular junction, thereby altering the time course of transmitter …
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Antioxidant and anticholinesterase activities of centella asiatica phenolic extract-mediated gold nanoparticles
… contents (TPC and TFC), antioxidant and anticholinesterase (anti-ChE) activities were also tested in vitro and Pearson correlation analysis was performed. The GNP synthesis using CAP was successfully accomplished under optimum conditions of reactants ratio of 1:1, 8 % CAP concentration, …
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The Effects of Atropine Sulfate on Flight Simulator Performance and on Respiratory-Heart Period Interactions (Human, Electrocardiogram, Organophosphorous)
… is an important therapeutic agent for treating anticholinesterase toxicosis, but atropine also is a strong anticholinergic drug with side effects. Twenty volunteers received a placebo control and atropine doses of 0.5, 1.0, 2.0, and 4.0 mg/75 kg in a Latin Square double blind design, and effects …
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The Development and Use of an Intraoral Force Transducer in the Diagnosis and Treatment of Myasthenia Gravis
… conjunction with the intravenous injection of an anticholinesterase drug (Tensilon). Twenty-three known myasthenic patients were tested, as well as nine normal individuals. This examination consisted of a battery of tests to determine the subjects’ incisive biting force, vital capacity, grip …
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Toxicological Analysis of Tacrines and Verapamil on the Yellow Fever Mosquito, Aedes aegypti
… with the target-site delivery and action of anticholinesterase chemistries. The ATP-binding cassette (ABC) transporters are efflux proteins that assist in maintaining the BBB interface and serve as a first line of defense to mosquitocide exposures. To date, there are three subfamilies (ABC …
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The design and synthesis of novel tacrine analogues
… Compounds were produced which showed activity as anticholinesterase agents and 5-HT uptake inhibitors.
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Mechanistic Studies on Memory of Chirality Alkylations of 1,4-Benzodiazepin-2-ones & Structure-based Design of Insecticidal AChE Inhibitors for Malaria Mosquito, Anopheles gambiae
… the risk of malaria transmission. Current use of anticholinesterase insecticides has been limited by their toxicity to human beings. A major African malaria insect vector, Anopheles gambiae (Ag), was targeted. Based on sequence alignment and homology models of AgAChE, a strategy of dual-site …
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The neurotoxicity of acrylamide
… in vitro exposure to the organophosphorous anticholinesterase compound ecothiopate were altered by in vivo pre treatment with acrylamide. Acrylamide caused an increase in the time course of the potentiation of stimulated twitches and a decrease in the maximum potentiation. Spontaneous …
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Symbiont-Mediated Modification of Mosquitocide Toxicity in the Dengue Vector, Aedes aegypti
… combination with PBO resulted in a decrease in anticholinesterase activity (higher residual AChE activity) and a subsequent decrease in toxicity of the insecticide. This suggests that esterases play a major role in the metabolic detoxification of both insecticides in mosquito larvae. The acute …
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Development of Novel Nicotinic Receptor Mediated Therapeutic Agents: Synthesis and Biological Evaluation of Novel Epibatidine Analogs and the First Total Synthesis of Anabasamine and Related Analogs
… biological activity such as exhibiting anticholinesterase activity, anti-inflammatory activity, and facilitated an increase in hepatic alcohol dehydrogenase levels. Only preliminary studies were performed as anabasamine is limited in quantity due to its difficult isolation. A versatile …
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Small Core Heterocyclic Carbamates and Carboxamides: Resistance-breaking Acetylcholinesterase Inhibitors Targeting the Malaria Mosquito, Anopheles gambiae
… would certainly be favorable for a new anticholinesterase-based mosquitocide targeting both the susceptible and resistant strain mosquitoes. Although the overall selectivity (Ag vs human) did not exceed 24-fold, the heterocyclic carbamates and carboxamides synthesized by the author …
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Design, development, and evaluation of novel polymer-drug conjugates and interpolymer complexes for the treatment of neurodegenerative disease.
Neurodegenerative diseases (NDs) pose a growing global healthcare challenge due to their complex aetiology. Alzheimer's disease (AD), the most prevalent form of dementia, is a progressive ND characterised by amyloid-beta (Aβ) plaques and neurofibrillary tangles (NFTs), largely driven by oxidative …
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Respiratory complications of organophosphorus pesticide poisoning
… Asia with organophosphorus (OP) compounds. These anticholinesterase pesticides cause an acute cholinergic syndrome characterised by decreased consciousness, excessive airway secretions and respiratory failure. A combination of these clinical features is the most common cause of death. Up to 30% of …