Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"Anticancer therapy"”.
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The proteomic analysis of resistance to anticancer therapy in human breast cancer
Resistance to anticancer therapy represents a major barrier in the successful management of human breast cancer. The identification of novel biomarkers that correlate with treatment response would increase our understanding of the resistance mechanisms and may allow therapy to be tailored on an …
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Probing Proteasome Inhibition By Metal Copmplexes As A New Route For Anticancer Therapy
… investigated along with their in vitro anticancer properties against the growth of prostate cancer PC-3 cells. It has been demonstrated that apoptosis induction of the PC-3 cells is due to the inhibition activity of the 26S proteasome upon treatment of various concentrations of these …
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Metastatic cell responses to anticancer therapy: The possible role of cancer stem cells
… lectin extract from Helix pomatia snails. Radiotherapy could have an effect on cancer metastasis; by stimulating regulation signalling including ROS, TGF-β, E-cadherin and vimentin. This signalling can promote cancer cells to change from the epithelial to mesenchymal form. The cells behaviour …
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Design, Synthesis and Characterization of Photoactivable Cyclodextrin-Based Nanoparticles for Multimodal Anticancer Therapy
… into tremendous way to achieve multimodal anticancer and antimicrobial therapeutic actions. Here the cyclodextrins act as the building block for the development of the nanocarrier in order to convey the therapeutic payload to the desired site. With this goal in mind, we have developed …
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Synthesis of proteasome inhibitors: analogues of nelfinavir
… nelfinavir 1 a very promising target for the anticancer therapy development. In this project, the synthesis of two nelfinavir 1 analogues was attempted, based on the replacement of the thiophenyl group by indole or phenyl group to give 2 and 3 respectively. The analogues were prepared in seven …
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Turning stealth liposomes into cationic liposomes for anticancer drug delivery
<p>Targeting the anticancer agents selectively to cancer cells is desirable to improve the efficacy and to reduce the side effects of anticancer therapy. Previously reported passive tumor targeting by PEGylated liposomes (stealth liposomes) have resulted in their higher tumor accumulation. However …
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Štúdium modulácie cytostatickej rezistencie pomocou vybraných cielených protinádorových liečiv
… of cytostatic resistance using selected targeted anticancer drugs Cancer diseases rank among the most common causes of death, with increasing prevalence and incidence. The effectiveness of anticancer therapy is often diminished by multidrug resistance (MDR), which frequently leads to disease …
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New Roles for the Integrated Stress Response in Cancer and Proteostasis
… promoted proteostasis in response to the chemotherapy and proteasome inhibitor, bortezomib. We found this second finding to be mechanistically linked to a previously-undescribed role for the ISR in regulating the microtubule cytoskeleton to promote the removal of aggregated proteins. As a …
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Developments in the chemistry and nanodelivery of platinum anticancer agents
… half of all patients receiving cancer chemotherapy are treated with a platinum-containing drug. Despite this intense clinical use, only three platinum complexes, cisplatin, carboplatin, and oxaliplatin, are approved by the United States Food and Drug Administration for the treatment of …
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Development and application of bioorthogonal palladium- labile derivatives of cytotoxic pyrimidine analogues
Chemotherapy is widely used to treat various forms of cancer. However, some chemotherapeutic drugs, due to their antineoplastic properties, also act upon healthy cells which normally replicate rapidly causing a plethora of undesirable side effects. One rising and promising therapeutic strategy is …
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Characterization Of Protein Prenyltransferases And Protein Prenylation In Plasmodium Falciparum
… have been established as a target for anticancer therapy. Research done in our laboratory has demonstrated recently that prenyl modification of proteins could be a novel target for the development of antimalarial drugs.The goal of this study is to understand the molecular mechanism of …
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Development of genotyping systems for pharmacogenomics profiling
… for genotyping ten polymorphisms related to anticancer drugs and ten polymorphisms related to cholesterol lowering drugs. SNaPshot minisequencing and high resolution melt analysis (HRM) genotyping panels were developed, optimized, and their performances were evaluated and compared. SNaPshot …
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Studio di complessi di rame (II) e platino (II) con proprietà antitumorali
Cisplatin is one of the most active drugs in anticancer therapy, and it is currently used for the treatment of a wide range of cancers, in particular advanced ones. After its introduction in clinical therapy, the research in this field has focused on the preparation of new metal complexes with …
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The development of a radiolabelled macromolecule as a therapeutic agent for the treatment of cancer
One of the major focus areas of anticancer therapy is the design of new radiotherapeutic agents that are able to specifically target and destroy cancer cells with minimal side effects and damage to healthy, normal cells. This thesis describes studies towards the synthesis of a macromolecular …
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The role of autophagy in canine osteosarcoma
… is unclear. Targeting autophagy as an anticancer therapy is complicated by its nature of dual role: activating autophagy can prevent apoptosis promoting cell survival or it could be a trigger leading to cell death. Drug resistance is thought to be the main cause and overcoming this …
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DEVELOPMENT OF A NANOPARTICLE-BASED PLATFORM FOR THE DELIVERY OF THERANOSTIC AGENTS TO TUMOR TISSUE: TOWARD CLINICAL TRANSLATION
The selective delivery of anticancer agents to tumor tissue remains a major challenge in oncology, as many clinically effective drugs are limited by poor tumor specificity and dose-limiting systemic toxicity. Previous studies from the laboratory have explored the use of tumor-derived and …
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Modulation of heme oxygenase-1 activity by novel synthetic compounds for pharmacological applications
… has been proposed as a stand-alone or adjuvant anticancer therapy, and a library of imidazole-based HO-1 inhibitors has been synthesized. On these grounds, the first part of this thesis focuses on the development of novel arylethanolimidazoles, designed through modifications of previously …
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Procaspase-3 activation as a strategy to overcome resistance to targeted anticancer therapies
… in exploiting procaspase-3 overexpression as an anticancer strategy. In particular, I will outline the preclinical and clinical development of a selective procaspase-3 activating small molecule (PAC-1) as an anticancer therapy. Activation of an executioner caspase such as caspase-3 leads to …
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