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Showing 1 to 12 of 12 for “"Anticancer drug delivery"”.
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Application of HCRSV protein cage for anticancer drug delivery
… virus (HCRSV) was explored as a platform for anticancer drug delivery. PC was prepared by removing viral RNA from coat proteins by dialysis against a Ca2+-deficient buffer of pH 8.0, and reassembling the coat proteins by dialysis with a Ca2+-containing buffer of pH 5.0. Using polyacids and …
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Turning stealth liposomes into cationic liposomes for anticancer drug delivery
<p>Targeting the anticancer agents selectively to cancer cells is desirable to improve the efficacy and to reduce the side effects of anticancer therapy. Previously reported passive tumor targeting by PEGylated liposomes (stealth liposomes) have resulted in their higher tumor accumulation. However …
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Design of Functional Polymeric Micelles as a Carrier for Anticancer Drug Delivery
… nanoparticles are frequently utilized as drug delivery carriers due to their particular core/shell structure, ease of functionalization, sustained circulation in the blood and its ability to passively accumulate in leaky tumor tissues. Two important factors that should be considered in the …
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PREPARATION AND EVALUATION OF MESOPOROUS SILICA NANOPARTICLES FOR PLATINUM-ACRIDINE ANTICANCER DRUG DELIVERY
… as an inert carrier material in oncology drug formulations. In this dissertation, MSNs were prepared and suitably functionalized to serve as a chemically robust and biocompatible delivery platform for highly cytotoxic platinum-acridine anticancer agents. The first part of the thesis …
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Design and Synthesis of Doxorubicin Conjugated Gold Nanoparticles as Anticancer Drug Delivery System
… is one of the most widely used and effective anticancer agents to treat a wide spectrum of tumors. But its success in cancer therapy is greatly compromised by its cumulative dose-dependent side effects of cardiotoxicity and tumor cell resistance. For the purpose of addressing these side …
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Functionalising peptide hydrogels to improve drug delivery for the treatment of glioblastoma
… (BBB) preventing the systemic transport of many drugs into the brain, restricting treatment options; and (iii) the highly aggressive and infiltrative nature of GBM, which increases the likelihood of cancer cells remaining in the brain after treatment, responsible for high rates of recurrence. As …
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Functionalising peptide hydrogels to improve drug delivery for the treatment of glioblastoma
… (BBB) preventing the systemic transport of many drugs into the brain, restricting treatment options; and (iii) the highly aggressive and infiltrative nature of GBM, which increases the likelihood of cancer cells remaining in the brain after treatment, responsible for high rates of recurrence. As …
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Liposome drug delivery systems for anticancer agents
… of liposome formulation of an amphiphilic anticancer peptide using the ANTS/DPX leakage assay. The effects of lipid composition on the liposomes' resistance to an amphiphilic cyclic peptide c[KS.S.S.KWL W] were studied by the ANTS/DPX leakage assay. One or more unsaturated acyl chains in …
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Amphipathic Hybrid Cyclic-Linear Peptides as a Drug Delivery System
<p>Amphipathic Hybrid Cyclic-Linear Peptides as a Drug Delivery System by Jonathan A. Moreno Peptides</p> <p>[RW]<sub>4</sub> and [R<sub>5</sub>W<sub>4</sub>] have been previously identified as molecular transporter Cell Penetrating Peptide (CPP) and antimicrobial agents, respectively. These …
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Design strategies and application of stimuli-responsive nanoparticles for cancer diagnosis and therapy
Small molecule anticancer drugs are the first-line therapy used in clinical cancer management which has shown success in the killing of rapidly dividing cancer cells. However, nonspecific distribution of these small molecular therapeutics has adverse side effects reducing the quality of life. …
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Multifaceted computational modelling in pharmaceutical research and development
Drug development is a multi-step process and takes around 12 to 15 years for a new drug to get approved. In the current scenario, to accelerate the drug development process and to reduce the time frame, most pharmaceutical companies have in-house developed workflows comprised of a hybrid use of …
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Nanotherapies for Treating Prostate Cancer
… physiological barriers which hinder efficacy of anticancer agents. Therefore, the focus of this study was to investigate a new combination therapy approach for treating prostate cancer and develop polymeric nanocarriers to facilitate anticancer drug and nucleic acid delivery.</p> <p>It was …