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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 145 for “"Anticancer activity"”.
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Anticancer activity of ceratotheca triloba
Submitted in complete fulfillment for the Degree of Doctorate of Philosophy in Biotechnology, Durban University of Technology, Durban, South Africa, 2016.
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Anticancer activity of Lovage (Levisticum officinale Koch) extracts
… (Lovage), and to assess whether they had any anticancer properties. Two human cancer cell lines were used in the anticancer screening assays (THP-1, a leukaemia cell line and MCF7, epithelial breast cancer cells) and a modified normal cell line (PNT2A, prostate epithelial cells). The n-hexane, …
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Chemical diversification and anticancer activity of natural products
Made available in DSpace on 2014-01-16T18:25:34Z (GMT). No. of bitstreams: 3 Karen_Morrison.pdf: 14532423 bytes, checksum: af6a40d935f8782447ddd84ef12a94ae (MD5) Morrison_Karen.docx: 44256739 bytes, checksum: 6353cc66b66320dd9c663bda8c68747b (MD5) license.txt: 4063 bytes, checksum: …
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Understanding and improving the anticancer activity of cisplatin
… (cisplatin), one of the most effective anticancer drugs. Since its serendipitous discovery in 1970, cisplatin has served to help cure testicular cancer and treat a variety of human malignancies. It is widely accepted that DNA is the cellular target for cisplatin. Prior to this work, …
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Chemical investigation of Dicranum fulvum for anticancer activity
… the species Dicranum fulvum gave extracts with activity in both <u>in vitro</u> and <u>in vivo</u> bioassays. This plant was thus selected for extraction and fractionation, monitored by i<u>in vitro</u> bioassays. Isolation was guided by a combination of bioassay and chemical methods, and led to …
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Synthesis of sphingosine analogues and evaluation of anticancer activity
No abstract available.
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Enhanced Etoposide Solubility and Anticancer Activity using Complexation and Nanotechnology
… the three main drawbacks which hamper etoposide activity. The central hypothesis of this work is to enhance etoposide (VP-16) solubility, dissolution, and improve its antitumor activity using emerging formulations strategies such as complexation and nanotechnology. To test this hypothesis, three …
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Investigation of the anticancer activity and molecular mechanisms of Disulfiram in Glioblastoma Multiforme
… between HIFs, NF-B activation and ALDH activity and their role in chemoresistance.The findings of this study demonstrated that GBM cells grown as spheres consist of a vast proportion of hypoxic cells with elevated CSC and EMT markers suggesting hypoxia induced EMT. GBM-CSCs are …
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Investigation of the anticancer activity and mechanisms of zinc diethyldithiocarbamate in multiple myeloma
… over 70 years, demonstrates excellent specific anticancer activity with no/low toxicity to normal tissues. DS chelates with transition metals such as copper and zinc to form metal-metabolite complexes (zinc/copper diethyldithiocarbamate), which are the active anticancer compounds. …
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Molecular mechanisms involved in the anticancer activity of BISPMB in oesophageal cancer cells
… had no effect on bisPMB antiproliferative activity against WHCO1 cells. On the other hand, inhibition of ERK1/2 MAPK by U0126 enhanced the anti-proliferative effect of bisPMB in WHCO1 cells. These results support the hypothesis that ER stress and MAPK signalling pathways are essential for …
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Synthesis, characterization, and anticancer activity of arene mono-ruthenium and heteroleptic mixed-valent diruthenium complexes
… complexes (where R = CH3 or F) improves the anticancer activity against the afore-mentioned human breast cancer cells. Anilinopyridinate-type ligands were synthesized through a facile nucleophilic aromatic substitution reaction between 2-bromopyridine and the corresponding substituted …
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Investigation of anticancer activity and mechanisms of Meso- 2,3-dimercaptosuccinic acid (DMSA) in glioblastoma cell lines
… FDA approved anti alcoholism drug has excellent anticancer activity against a wide range of cancers with its metal binding capability through its unique dithiol structure. Hence our group is interested in identifying clinically used dithiol compounds which are structurally similar to DS and has …
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Design and Evaluation of Cyclic Peptide-Epirubicin Conjugate for Enhanced Anticancer Activity and Reduced Myocardial Toxicity
… resistance and the non-specific distribution of anticancer drugs to healthy cells pose challenges that limit the clinical application of these drugs.</p> <p>Epirubicin (EPI) is a topoisomerase II Inhibitor and an antineoplastic agent used to treat acute myeloid leukemias, multiple sclerosis …
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In vitro and in vivo investigation of the anticancer activity and mechanism of disulfiram in malignant mesothelioma
… the treatment of alcoholism, has shown potential anticancer effects in combination with metal ions (Cu, Zn), primarily due to its ability to generate reactive oxygen species (ROS), inhibit aldehyde dehydrogenase (ALDH) activity, and disrupt the self-renewal of CSCs. While promising outcomes have …
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Anticancer Activity of Natural Health Products (Dandelion Root, Lemongrass, and Hibiscus Extracts); A Study of Efficacy, Interaction, and Mechanism of Action
… extract (HE) exhibit selective anti-cancer activity. These extracts were also able to enhance the anticancer efficacy of common chemotherapeutics and protect normal healthy cells from toxicity. In mice xenografted with human cancer cells, DRE and LGE were able to reduce tumour burden and LGE …
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In vitro and in vivo investigation of the anticancer activity and molecular mechanisms of disulfiram in non-small cell lung cancer
… DS demonstrates excellent in vitro anti-CSC activity in a wide range of cancers. Cytotoxicity of DS is copper (II) (Cu)-dependent. DS/Cu induces reactive oxygen species and inhibits NF-κB activity, leading cancer cells into apoptosis. The clinical application of DS as an anticancer drug is …
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Isolation and identification of an antimicrobial peptide with high anticancer activity and selectivity, QUB-2584 from the skin secretion of Litoria caerulea
… 2, 8, and 32 μM, respectively. There was great anticancer activity of it against the cell line U251MG especially at concentration of 10 -4 M. Besides, it showed haemolytic activity with 36.6 % haemolysis at 32 μM. Hence, the peptide deserved great attention as potential therapeutics due to its …
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In vitro investigation of the anticancer activity and molecular mechanisms of action of albumin nano-encapsulated copper/zinc diethyldithiocarbamate in human pancreatic cancer cells
… anti-alcoholism drug, has demonstrated potent anticancer activity when chelated with Cu²⁺ or Zn²⁺ ions to form copper diethyldithiocarbamate (Cu(DDC)₂) or zinc diethyldithiocarbamate (Zn(DDC)₂). However, the clinical anticancer application of DSF is hindered by a short plasma half-life (<4 …
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A Structure-Activity Relationship Study with Isoquinolinone Compounds and Stromal Antigen 2 Mutant Ewing’s Sarcoma Cells and Synthesis of Small Molecules for Anticancer Activity Through TEAD Palmitoylation Inhibition
… first section will be focused on the structure-activity relationship study with isoquinolinone compounds, and the second on the synthetic approach to small molecules that inhibit the growth of cancer cells through the Hippo signaling pathway. Ewing’s sarcoma is the second most commonly diagnosed …
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